Patents Assigned to Mebiopharm Co., Ltd.
-
Publication number: 20140363491Abstract: The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.Type: ApplicationFiled: May 9, 2014Publication date: December 11, 2014Applicant: Mebiopharm Co., Ltd.Inventors: Kazushi OKADA, Tadayuki IBUKI, Donghyun KIM, Tadashi FUJISAWA
-
Patent number: 8758810Abstract: The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.Type: GrantFiled: September 27, 2010Date of Patent: June 24, 2014Assignee: Mebiopharm Co., Ltd.Inventors: Kazushi Okada, Tadayuki Ibuki, Donghyun Kim, Tadashi Fujisawa
-
Publication number: 20110081404Abstract: The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.Type: ApplicationFiled: September 27, 2010Publication date: April 7, 2011Applicant: Mebiopharm Co., Ltd.Inventors: Kazushi Okada, Tadayuki Ibuki, Donghyun Kim, Tadashi Fujisawa
-
Patent number: 7829113Abstract: The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.Type: GrantFiled: March 8, 2006Date of Patent: November 9, 2010Assignee: Mebiopharm Co., Ltd.Inventors: Kazushi Okada, Tadayuki Ibuki, Donghyun Kim, Tadashi Fujisawa
-
Publication number: 20090214629Abstract: A method for efficiently transferring a gene to a target cell is provided. A method of transferring a gene to a target cell, including adding or administering a positively charged complex (A) composed of the gene and a cationic substance and gas-filled microparticles (B) to a target cell-containing composition or a living body and then exposing the target cell-containing composition or the living body to a low-frequency ultrasound.Type: ApplicationFiled: May 26, 2005Publication date: August 27, 2009Applicant: Mebiopharm Co., LtdInventors: Kazuo Maruyama, Tomoko Takizawa, Kosuke Hagisawa, Toshihiko Nishioka, Hironobu Yanagie
-
Publication number: 20090110643Abstract: Gas-filled liposomes that are useful for ultrasonography and ultrasound therapy are provided. A method of producing the gas-filled liposomes, including filling the void space in a sealed container containing a liposome suspension in a volume amounting to 20 to 80% of the inner capacity thereof with a fluoride gas or a nitrogen gas, and subjecting the container to an ultrasonication.Type: ApplicationFiled: May 23, 2005Publication date: April 30, 2009Applicant: MEBIOPHARM CO., LTD.Inventors: Kazuo Maruyama, Tomoko Takizawa, Kosuke Hagisawa, Toshihiko Nishioka, Hironobu Yanagie
-
Publication number: 20040022842Abstract: The present invention provides a liposome preparation containing oxaliplatin and derivatized with a hydrophilic polymer and a ligand. In one embodiment the hydrophilic polymer is polyethylene glycol and the ligand is transferrin. In accordance with the invention, the uptake of a pharmaceutical agent contained in the liposome into tumor cells can be enhanced through transferrin receptors expressed on the surface of the tumor cells. Also provided are pharmaceutical compositions containing the liposomes and methods of their use.Type: ApplicationFiled: June 3, 2003Publication date: February 5, 2004Applicant: Mebiopharm Co., Ltd.Inventors: Masazumi Eriguchi, Hironobu Yanagie, Kazuo Maruyama, Tadashi Fujisawa
-
Publication number: 20030224037Abstract: The present invention provides a liposome preparation containing oxaliplatin and derivatized with a hydrophilic polymer, as well as a pharmaceutical composition for treatment of tumor comprising the liposome preparation. The liposome preparation according to the present invention is characterized in that it is derivatized with a ligand. The ligand is preferably transferrin. In accordance with the invention, the uptake of a pharmaceutical agent in the liposome into tumor cells can be enhanced through transferrin receptors expressed on the surface of the tumor cells.Type: ApplicationFiled: October 11, 2002Publication date: December 4, 2003Applicant: Mebiopharm Co., Ltd.Inventors: Masazumi Eriguchi, Hironobu Yanagie, Kazuo Maruyama, Tadashi Fujisawa