Patents Assigned to Medi-Physics, Inc.
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Patent number: 6128918Abstract: A resilient container configured to receive a quantity of hyperpolarized noble gas includes a wall with at least two layers, a first layer with a surface which minimizes spin-relaxation and a first or second layer which is substantially impermeable to oxygen. The container is especially suitable for collecting and transporting .sup.3 He. The resilient container can be configured to directly deliver the hyperpolarized noble gas to a target interface by deflating or collapsing the inflated resilient container. Related collection and transporting methods include forming the wall of the container and collecting the hyperpolarized gas in a way which minimizes its exposure to de-polarizing impurities. Also, a container includes a quantity of polarized gas and extends the T.sub.1 life by configuring the wall of the container with a controlled thickness of the surface coating and overlays the interior with an exterior which is substantially impermeable to oxygen.Type: GrantFiled: July 30, 1998Date of Patent: October 10, 2000Assignee: Medi-Physics, Inc.Inventors: Daniel M. Deaton, Patrick A. Cella, Kenton C. Hasson, David Zollinger, Bastiaan Driehuys
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Patent number: 5080884Abstract: An agent for imaging organs using a radioactive complex of a radioactive metal with a benzene ring having two 2-mercapto-2-methylpropylamino substituents where one of these mercapto substituents is substituted with a hydrocarbyl group.Type: GrantFiled: February 22, 1991Date of Patent: January 14, 1992Assignee: Medi-Physics, Inc.Inventors: William J. McBride, Ronald M. Baldwin, Janice M. Kerr, Lisa M. Schultze, Nilda Salazar, James M. Chinitz
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Patent number: 5026913Abstract: An agent for imaging organs using a radioactive complex of a radioactive metal with a benzene ring having two 2-mercapto-2-methylpropylamino substitutents where one of these mercapto substituents is substituted with a hydrocarbyl group.Type: GrantFiled: August 30, 1990Date of Patent: June 25, 1991Assignee: Medi-Physics, Inc.Inventors: William J. McBride, Ronald M. Baldwin, Janice M. Kerr, Lisa M. Schultze, Nilda Salazar
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Patent number: 4575556Abstract: Novel homocysteine thiolactone bifunctional chelating agents useful for chelating radionuclides to produce a radiodiagnostic agent for use in in vivo imaging and a method for producing this chelating agent.Type: GrantFiled: November 28, 1983Date of Patent: March 11, 1986Assignee: Medi-Physics, Inc.Inventors: Edmund F. Byrne, Glen L. Tolman
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Patent number: 4571430Abstract: Novel homocysteine thiolactone bifunctional chelating agents useful for chelating radionuclides to produce a radiodiagnostic agent for use in vivo imaging and a method for producing this chelating agent.Type: GrantFiled: November 28, 1983Date of Patent: February 18, 1986Assignee: Medi-Physics, Inc.Inventors: Edmund F. Byrne, Glen L. Tolman
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Patent number: 4565301Abstract: A device suitable for dispensing a radioactive gas from a sealed radioactive gas-containing vial having a pierceable septum wherein the dispenser contains two needles which pierce the septum, one of the needles conducting the radioactive gas from the vial into the dispenser and the other for the introduction of a displacement gas to the vial. The improvement being a means in the dispenser whereby the septum is automatically released from the needles without handling the vial so that the vial may be removed from the dispenser.Type: GrantFiled: June 10, 1982Date of Patent: January 21, 1986Assignee: Medi-Physics, Inc.Inventors: Robert E. Hubbard, Robert C. Wedemeyer
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Patent number: 4434151Abstract: Novel homocysteine thiolactone bifunctional chelating agents useful for chelating radionuclides to produce a radiodiagnostic agent for use in in vivo imaging and a method for producing this chelating agent.Type: GrantFiled: November 8, 1982Date of Patent: February 28, 1984Assignee: Medi-Physics, Inc.Inventors: Edmund F. Byrne, Glen L. Tolman
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Patent number: 4364920Abstract: Diagnostic reagents comprising a chelating agent and stannous tin which are suitable for conversion to radiopharmaceuticals by the addition of a radionuclide, such as suitable forms of technetium 99m, are stabilized against oxidation and/or hydrolysis by the addition to said complex of ascorbic acid, erythorbic acid, pharmaceutically acceptable inorganic salts thereof or mixtures thereof.Type: GrantFiled: April 30, 1975Date of Patent: December 21, 1982Assignee: Medi-Physics, Inc.Inventor: Harry S. Winchell
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Patent number: 4360511Abstract: Certain radioiodine containing amines useful as brain imaging agents are disclosed. The compounds of the invention are represented by the formula ##STR1## wherein I is a radioisotope of iodine with I-123 being preferred, R is lower alkyl or halogen, R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen and lower alkyl, R.sub.3 and R.sub.4 are the same or different and are selected from the group consisting of hydrogen, alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl and substituted carbamoyl methyl or R.sub.3 and R.sub.4 taken together with the nitrogen to which they are attached form a 5- or 6-membered ring which may be substituted with one or more lower alkyl groups, x is 0 to 4, y is 0 to 3 and z is 0 or 1 and pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: June 19, 1980Date of Patent: November 23, 1982Assignee: Medi-Physics, Inc.Inventors: Ronald M. Baldwin, Tz-Hong Lin, Harry S. Winchell
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Patent number: 4284619Abstract: Certain radioiodine containing esters useful as brain imaging agents are disclosed. The compounds of the subject invention are represented by the formula ##STR1## wherein I is a radioisotope of iodine with iodine-123 being preferred and R is selected from the group consisting of alkyl, aryl, substituted aryl, aralkyl, a polyhydric alcohol radical and a 5- or 6-membered heterocyclic ring.Type: GrantFiled: November 29, 1978Date of Patent: August 18, 1981Assignee: Medi-Physics, Inc.Inventor: Tz-Hong Lin
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Patent number: 4279887Abstract: Certain radioiodine containing amides useful as brain imaging agents are disclosed. The compounds of the subject invention are represented by the formula ##STR1## wherein I is a radioisotope of iodine with I-123 being preferred, R.sub.1 and R.sub.2 are the same or different and are selected from the grooup consisting of hydrogen, hydroxy, alkyl, aryl, substituted aryl, aralkyl, anilino and carbamoylmethyl or R.sub.1 and R.sub.2 taken together with the nitrogen to which they are attached form a 5- or 6-membered ring.Type: GrantFiled: November 29, 1978Date of Patent: July 21, 1981Assignee: Medi-Physics, Inc.Inventors: Ronald M. Baldwin, Tz-Hong Lin, Harry S. Winchell
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Patent number: 4233285Abstract: Mercaptocarboxylic acid chelated heavy metal radioisotope pharmaceuticals and methods for making them.Type: GrantFiled: May 14, 1973Date of Patent: November 11, 1980Assignee: Medi-Physics, Inc.Inventors: Harry S. Winchell, Tz-Hong Lin
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Patent number: 4176173Abstract: Radiographic contrast media preparations suitable for use with high-energy x-ray sources and useful for intestinal tract studies and, in particular, computerized tomography are disclosed. The disclosed preparations comprise aqueous solutions of stable, non-toxic complexes of hafnium and tantalum with certain organic acids.Type: GrantFiled: July 18, 1977Date of Patent: November 27, 1979Assignee: Medi-Physics, Inc.Inventors: Harry S. Winchell, Tz-Hong Lin, Charles A. Panneciere
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Patent number: 4079124Abstract: A method of preparing enteric X-ray contrast media particularly suited to the use of high energy X-ray sources are disclosed. The disclosed media comprise hafnium, tantalum, tungsten, oxides or insoluble salts thereof in purified form, mixtures thereof and, more particularly, partially purified ores containing one or more of them in combination with a suitable carrier.Type: GrantFiled: April 21, 1976Date of Patent: March 14, 1978Assignee: Medi-Physics, Inc.Inventor: Harry S. Winchell
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Patent number: 4066742Abstract: A Tc-99m stannous sulfur colloid radiopharmaceutical having simplicity of formulation, improved stability and desirable small particle size as well as a method of preparation therefor are described. Also provided is a reagent suitable for the preparation of such radiopharmaceutical by the addition thereto of technetium-99m pertechnetate.Type: GrantFiled: February 14, 1977Date of Patent: January 3, 1978Assignee: Medi-Physics, Inc.Inventor: Michael David Garrett
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Patent number: 4024233Abstract: A reagent comprising macroaggregated human serum albumin having dispersed therein particles of stannous tin and a method for instantly making a labeled pharmaceutical therefrom, are disclosed. The labeled pharmaceutical is utilized in organ imaging.Type: GrantFiled: July 24, 1974Date of Patent: May 17, 1977Assignee: Medi-Physics, Inc.Inventors: Harry S. Winchell, Morton Barak, Parmer Van Fleet, III
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Patent number: 4001387Abstract: A process for the preparation of technetium-99m labeled pharmaceuticals is disclosed. The process comprises initially isolating technetium-99m pertechnetate by adsorption upon an adsorbent packing in a chromatographic column. The technetium-99m is then eluted from the packing with a biological compound to form a radiopharmaceutical.Type: GrantFiled: January 2, 1975Date of Patent: January 4, 1977Assignee: Medi-Physics, Inc.Inventors: Morton Barak, Harry S. Winchell
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Patent number: 3981769Abstract: An improved process for preparation of fluorine-18 by a neon (deuteron, alpha particle) fluorine-18 nuclear reaction in a non-reactive enclosed reaction zone wherein a ultrapure product is recovered by heating the reaction zone to a high temperature and removing the product with an inert gas.Type: GrantFiled: August 29, 1974Date of Patent: September 21, 1976Assignee: Medi-Physics, Inc.Inventors: Harry S. Winchell, Dale K. Wells, James F. Lamb, Samuel B. Beaudry
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Patent number: 3968221Abstract: An improved 99m-technetium labeled tin(II) colloid, size-stabilized for reticuloendothelial organ imaging without the use of macromolecular stabilizers and a packaged tin base reagent and an improved method for making it are disclosed.Type: GrantFiled: June 10, 1974Date of Patent: July 6, 1976Assignee: Medi-Physics, Inc.Inventors: Harry S. Winchell, Morton Barak, Parmer Van Fleet, III
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Patent number: 3957033Abstract: A disposable ventilation study system for dispensing a single-patient dosage of gaseous radioisotopes to patients for pulmonary function studies is disclosed. A gas impermeable capsule encloses the gaseous radioisotope and is stored within a radioactivity shielding body of valve means which shears the capsule to dispense the radioisotope to the patient. A breathing bag receives the patient's exhalation of the radioisotope and permits rebreathing of the radioisotope by the patient.Type: GrantFiled: August 15, 1973Date of Patent: May 18, 1976Assignees: General Electric Company, Medi-Physics, Inc.Inventors: Harry S. Winchell, Thomas C. Hall