Patents Assigned to Medical & Biological Laboratories, Co., Ltd.
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Publication number: 20110293618Abstract: The present invention provides novel antibodies that recognize the extracellular domain of a human CLCP1 antigen; nucleic acids encoding the antibodies; vectors carrying the nucleic acids in an expressible manner; transformed cells containing the vectors; methods for producing the antibodies; diagnostic methods for cancer or prognosis of cancer, immunohistological or immunocytological assay methods, and kits for determining the expression level of CLCP1 in cells or tissues, all of which use the antibodies; pharmaceutical compositions comprising the antibodies; agents for treating or preventing CLCP1-expressing cancer; agents for inhibiting growth, migration, invasion, or metastasis of CLCP1-expressing cancer cells; immunostaining agents for staining CLCP1-expressing cancer cells; and agents for treating or preventing CLCP1-expressing tumor.Type: ApplicationFiled: July 16, 2009Publication date: December 1, 2011Applicants: Medical and Biological Laboratories Co., Ltd., Oncomics Co., Ltd.Inventors: Ken-ichiro Ono, Takashi Takahashi
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Publication number: 20110223636Abstract: It is an object of the present invention to provide a novel fluorescent protein and a novel chromoprotein. The present invention provides a novel fluorescent protein derived from Montipora sp., Acropora sp. and Lobophytum crassum, and a novel chromoprotein derived from Actinia equine.Type: ApplicationFiled: April 27, 2011Publication date: September 15, 2011Applicants: RIKEN, MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.Inventors: ATSUSHI MIYAWAKI, HIDEKAZU TSUTSUI, SATOSHI KARASAWA
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Patent number: 8017746Abstract: An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fluorescence) is greatened, so that the maximum fluorescence can be obtained by the maximum excitation. The present invention provides a novel fluorescent protein monomerized by introducing a mutation into a florescent protein derived from Fungia sp., and a novel chromoprotein and fluorescent protein derived from Montipora. sp.Type: GrantFiled: December 3, 2004Date of Patent: September 13, 2011Assignees: Riken, Medical & Biological Laboratories Co., Ltd.Inventors: Atsushi Miyawaki, Takako Kogure, Hiroshi Hama, Masataka Kinjo, Kenta Saito, Satoshi Karasawa, Toshio Araki
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Patent number: 7981637Abstract: It is an object of the present invention to provide a novel chromoprotein and a novel fluorescent protein. The present invention provides chromoproteins derived from Anthopleura inornata, which have certain property, and fluorescent proteins from Trachyphyllia geoffroyi and Scolymia vitiensis, which have certain fluorescent property.Type: GrantFiled: December 22, 2010Date of Patent: July 19, 2011Assignee: Medical & Biological Laboratories Co., Ltd.Inventors: Atsushi Miyawaki, Satoshi Karasawa
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Patent number: 7956172Abstract: It is an object of the present invention to provide a novel fluorescent protein and a novel chromoprotein. The present invention provides a novel fluorescent protein derived from Montipora sp., Acropora sp. and Lobophytum crassum, and a novel chromoprotein derived from Actinia equine.Type: GrantFiled: June 16, 2004Date of Patent: June 7, 2011Assignees: Riken, Medical & Biological Laboratories Co., LtdInventors: Atsushi Miyawaki, Hidekazu Tsutsui, Satoshi Karasawa
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Publication number: 20110104740Abstract: It is an object of the present invention to provide a novel chromoprotein and a novel fluorescent protein. The present invention provides chromoproteins derived from Anthopleura inornata, which have certain property, and fluorescent proteins from Trachyphyllia geoffroyi and Scolymia vitiensis, which have certain fluorescent property.Type: ApplicationFiled: December 22, 2010Publication date: May 5, 2011Applicant: MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.Inventors: Atsushi MIYAWAKI, Satoshi KARASAWA
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Patent number: 7892791Abstract: It is an object of the present invention to provide a novel chromoprotein and a novel fluorescent protein. The present invention provides chromoproteins derived from Anthopleura inornata, which have certain property, and fluorescent proteins from Trachyphyllia geoffroyi and Scolymia vitiensis, which have certain fluorescent property.Type: GrantFiled: May 8, 2009Date of Patent: February 22, 2011Assignees: RIKEN, Medical and Biological Laboratories Co., Ltd.Inventors: Atsushi Miyawaki, Ryoko Ando, Satoshi Karasawa, Hideaki Mizuno
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Publication number: 20110028470Abstract: The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.Type: ApplicationFiled: July 31, 2008Publication date: February 3, 2011Applicants: TOKAI UNIVERSITY EDUCATIONAL SYSTEM, RENASCIENCE CO., LTD., MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.Inventors: Masanari Itokawa, Toshio Miyata, Makoto Arai
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Publication number: 20110014626Abstract: Presence of free insulin receptor ?-subunit in blood was discovered. Furthermore, methods for measuring the insulin receptor ?-subunit was provided, the method comprising the steps of contacting the insulin receptor ?-subunit in a blood sample with an antibody recognizing the insulin receptor ?-subunit, and detecting the binding between the two. Measurement of the free insulin receptor ?-subunit in the blood is useful for evaluating risk factors for diabetes. In addition, the measurement methods of the present invention showed that concentrations of the free insulin receptor ?-subunit in the blood of diabetes or cancer patients are significantly high. Free insulin receptor ?-subunit in blood is useful as a marker for diabetes or cancer.Type: ApplicationFiled: April 30, 2010Publication date: January 20, 2011Applicant: Medical and Biological Laboratories Co., Ltd.Inventors: Yousuke Ebina, Toshiyuki Obata, Eiji Okamoto
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Publication number: 20100330554Abstract: The present invention provides novel solid cancer antigenic proteins, and diagnostic kits for solid cancer and therapeutic agents for solid cancer based on the antigenic proteins. Specifically, the present invention provides a human solid cancer antigenic polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75.Type: ApplicationFiled: May 18, 2009Publication date: December 30, 2010Applicants: MEDICAL & BIOLOGICAL LABORATORIES CO., LTD., HIDEAKI SHIMADAInventors: HIDEKI SHIMADA, TAKESHI TOMONAGA, TAKAKI HIWASA, KAZUYUKI MATSUSHITA, TAKENORI OCHIAI, FUMIO NOMURA, MASAKI TAKIGUCHI
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Publication number: 20100304497Abstract: It is an object of the present invention to provide a novel chromoprotein and a novel fluorescent protein. The present invention provides chromoproteins derived from Anthopleura inornata, which have certain property, and fluorescent proteins from Trachyphyllia geoffroyi and Scolymia vitiensis, which have certain fluorescent property.Type: ApplicationFiled: May 8, 2009Publication date: December 2, 2010Applicants: RIKEN, MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.Inventors: Atsushi MIYAWAKI, Ryoko ANDO, Satoshi KARASAWA, Hideaki MIZUNO
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Publication number: 20100297103Abstract: Disclosed is an antibody having an enhanced ADCC activity. Also disclosed is a method for producing the antibody. It was attempted to advance the technique of the amino acid mutation in an Fc region established by researchers of Genentech Inc. or the like, and a study was made on whether or not the ADCC activity can be enhanced by the mutation of an amino acid residue in an Fc region into cysteine (Cys) which may cause a drastic structural change that cannot be drawn by a computational search. As a consequence, a chemeric antibody is provided which has the mutation of an amino acid residue at least one position selected from the group consisting of 286th, 287th, 288th, 289th, 290th, 291st, 292nd, 294th, 298th, 301st, 302nd, 303rd, 305th, 306th, 307th, 308th and 309th positions into a Cys residue in an H-chain constant region.Type: ApplicationFiled: September 14, 2007Publication date: November 25, 2010Applicant: MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.Inventor: Akihiro Murakami
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Publication number: 20100267935Abstract: Disclosed is an antibody having a high inhibitory effect on amyloid fibril formation. An antibody is produced by using a liposome containing a GM1 ganglioside at a predetermined ratio as an immunogen. Thus, the sequences of four types of antibodies each having a high inhibitory effect on amyloid fibril formation can be provided.Type: ApplicationFiled: April 22, 2010Publication date: October 21, 2010Applicants: MEDICAL & BIOLOGICAL LABORATORIES CO., LTD., THE PRESIDENT OF NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY, KATSUHIKO YANAGISAWAInventors: KATSUHIKO YANAGISAWA, MASAO SHIBATA
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Patent number: 7741448Abstract: Disclosed is an antibody having a high inhibitory effect on amyloid fibril formation. An antibody is produced by using a liposome containing a GM1 ganglioside at a predetermined ratio as an immunogen. Thus, the sequences of four types of antibodies each having a high inhibitory effect on amyloid fibril formation can be provided.Type: GrantFiled: June 19, 2006Date of Patent: June 22, 2010Assignees: Medical & Biological Laboratories Co., Ltd., The President of National Center for Geriatrics and GerontologyInventors: Katsuhiko Yanagisawa, Masao Shibata
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Patent number: 7732154Abstract: Presence of free insulin receptor ?-subunit in blood was discovered. Furthermore, methods for measuring the insulin receptor ?-subunit was provided, the method comprising the steps of contacting the insulin receptor ?-subunit in a blood sample with an antibody recognizing the insulin receptor ?-subunit, and detecting the binding between the two. Measurement of the free insulin receptor ?-subunit in the blood is useful for evaluating risk factors for diabetes. In addition, the measurement methods of the present invention showed that concentrations of the free insulin receptor ?-subunit in the blood of diabetes or cancer patients are significantly high. Free insulin receptor ?-subunit in blood is useful as a marker for diabetes or cancer.Type: GrantFiled: April 15, 2004Date of Patent: June 8, 2010Assignee: Medical and Biological Laboratories Co., Ltd.Inventors: Yousuke Ebina, Toshiyuki Obata, Eiji Okamoto
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Publication number: 20100028946Abstract: Fusion partner cells that enable production of heterohybridomas even from cells of species other than mouse were produced by fusing myeloma cells derived from a first animal species with leukemia cells derived from a second animal species, which have an extra S phase in the cell cycle and have the property of diploidizing. Stable production of substances can be achieved by producing heterohybridomas through cell fusion between the fusion partner cells and substance-producing cells of an animal other than mouse.Type: ApplicationFiled: April 13, 2007Publication date: February 4, 2010Applicants: Medical & Biological Laboratories Co., Ltd.Inventors: Naomasa Yamamoto, Mizuho Kaneda
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Publication number: 20090305324Abstract: The present inventors introduced mRNAs for the Epstein-Barr virus proteins LMP1 and EBNA1 into antigen-presenting cells, and as a result, demonstrated that the cells induced Epstein-Barr virus-specific cytotoxic T cells. The present inventors also demonstrated that the cytotoxic T cells recognized epitope peptides presented via HLA-A*0206, HLA-Cw*0303, or HLA-Cw*0304, inhibited the outgrowth of Epstein-Barr virus-infected B cells, and lysed Epstein-Barr virus-infected NK lymphomas and NK cells.Type: ApplicationFiled: October 27, 2006Publication date: December 10, 2009Applicants: MEDICAL AND BIOLOGICAL LABORATORIES CO., LTD, AICHI PREFECTUREInventors: Kiyotaka Kuzushima, Yoshinori Ito, Ayako Okamura, Yoshiki Akatsuka, Yasuo Morishima
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Publication number: 20090280511Abstract: An objective of the present invention is to provide methods for selecting candidate peptides presented on the surface of cancer cells following binding to MHC class I molecules, wherein the peptides are involved in the stimulation of T cell immunity (cellular immunity). The present inventors discovered a new principle of MHC I-mediated antigen presentation in which a T cell antigen epitope is more efficiently presented on MHC I molecules when it is positioned at the N-terminal side than when positioned at the C-terminal side.Type: ApplicationFiled: November 25, 2008Publication date: November 12, 2009Applicants: Medical and Biological Laboratories Co., Ltd., Keio UniversityInventors: Ichiro Yahara, Shigeo Koyasu, Jun Imai
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Publication number: 20090170073Abstract: It is an object of the present invention to provide a novel fluorescent protein and a novel chromoprotein. The present invention provides a novel fluorescent protein derived from Montipora sp., Acropora sp. and Lobophytum crassum, and a novel chromoprotein derived from Actinia equine.Type: ApplicationFiled: June 16, 2004Publication date: July 2, 2009Applicants: RIKEN, MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.Inventors: Atsushi Miyawaki, Hidekazu Tsutsui, Satoshi Karasawa
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Publication number: 20090155888Abstract: The object of the present invention is to provide a novel fluorescent protein in which on and off of fluorescence thereof can be controlled by irradiation with lights of two different wavelengths. The present invention provides a fluorescent protein shown in the following (a) or (b); (a) a protein which has the amino acid sequence shown in SEQ ID NO: 3 or 7; or (b) a protein which has an amino acid sequence comprising a deletion, substitution, and/or addition of one or several amino acids with respect to the amino acid sequence shown in SEQ ID NO: 3 or 7, and which has fluorescence characteristics of exhibiting a photochromic effect.Type: ApplicationFiled: May 20, 2005Publication date: June 18, 2009Applicants: RIKEN, MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.Inventors: Atsushi Miyawaki, Ryoko Ando, Hideaki Mizuno, Satoshi Karasawa