Patents Assigned to Medical College of Pennsylvania
  • Compositions and methods for vaccines comprising &agr;-galactosyl epitopes
    Patent number: 6361775
    Abstract: The invention encompasses methods and compositions for inducing an immune response in an anti-Gal synthesizing animal including viral and tumor antigens manipulated to express &agr;-galactosyl epitopes.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: March 26, 2002
    Assignees: Medical College of Pennsylvania, Hahnemann University
    Inventors: Uri Galili, Patricia M. Repik
  • Compositions and methods for vaccines comprising .alpha.-galactosyl epitopes
    Patent number: 5879675
    Abstract: The invention encompasses methods and compositions for inducing an immune response in an anti-Gal synthesizing animal including viral and tumor antigens manipulated to express .alpha.-galactosyl epitopes.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: March 9, 1999
    Assignee: Medical College of Pennsylvania and Hahnemann University
    Inventors: Uri Galili, Patricia M. Repik
  • Method for finding transcription activators of the NER steroid hormone receptor
    Patent number: 5679518
    Abstract: The NER receptor is a novel member of the steroid hormone receptor superfamily and has been prepared by cDNA cloning from a human osteosarcoma SAOS-2/B10 cell library. The complete sequence of human NER complementary DNA (Seq. ID No. 1), expression systems including a COS stable expression system, the expressed protein (SEQ. ID No. 2) and an assay using the COS expression system are disclosed. The assay may be used to identify agents which activate transcription mediated by the NER receptor, and which are useful for potentiating the activity of a modulator of a G-protein coupled receptor wherein the G-protein coupled receptor is a member of the steroid hormone receptor superfamily.
    Type: Grant
    Filed: October 27, 1994
    Date of Patent: October 21, 1997
    Assignees: Merck & Co., Inc., Medical College of Pennsylvania, Hahnemann Univ.
    Inventors: Eitan Friedman, M. Katharine Holloway, Gideon A. Rodan, Su Jane Rutledge, Azriel Schmidt, Robert L. Vogel
  • Peptides having thrombospondin-like activity and their therapeutic use
    Patent number: 5654277
    Abstract: Methods of use of compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided for promoting or inhibiting thrombospondin-like activity.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 5, 1997
    Assignees: W. R. Grace & Co.-Conn., The Medical College of Pennsylvania
    Inventors: Jacob Eyal, Bruce King Hamilton, George Paul Tuszynski
  • Synthetic analogs of thrombospondin and therapeutic use thereof
    Patent number: 5648461
    Abstract: Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 15, 1997
    Assignees: W.R. Grace & Co.-Conn, The Medical College of Pennsylvania
    Inventors: Jacob Eval, Bruce King Hamilton, George Paul Tuszynski
  • Method for using synthetic analogs of thrombospondin for inhibiting angiogenesis activity
    Patent number: 5506208
    Abstract: Methods of use of compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided for promoting or inhibiting thrombospondin-like activity.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: April 9, 1996
    Assignees: W. R. Grace & Co.-Conn., The Medical College of Pennsylvania
    Inventors: Jacob Eyal, Bruce K. Hamilton, George P. Tuszynski
  • Treatment of Cryptococcus neoformans infection
    Patent number: 5434163
    Abstract: A method of treatment of Cryptococcus neoformans infection by administering to a patient in need thereof an effective amount of a benzimidazile compound.
    Type: Grant
    Filed: May 14, 1993
    Date of Patent: July 18, 1995
    Assignee: The Medical College of Pennsylvania
    Inventors: Thomas D. Edlind, Maria C. Cruz
  • Inosinic acid dehydrogenase assay
    Patent number: 5358855
    Abstract: A cyto(histo)chemical technique for determining inosine 5'-monophosphate dehydrogenase (IMPD) presence and concentration within one or more morphologically classified or classifiable cells taken from an animal or a human subject. Cell monolayers are prepared, fixed and stained according to a specified procedure in which inosine 5'-monophosphate (as enzyme substrate), nicotinamide adenine dinucleotide (NAD), phenazine methosulfate (PMS) and nitro blue tetrazolium (NBT) as a diazonium salt together produce a granular, dark blue deposit of formazan generally proportional to the IMPD activity in the cell. Cells are evaluated either visually or by image analysis, with a computerized image analyzer or other imaging system, according to accepted biostatistical methods and standards.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: October 25, 1994
    Assignee: The Medical College of Pennsylvania
    Inventors: Olivera T. Markovic, Nenad S. Markovic, Jay Roberts, Charles D. Puglia, Svetomir N. Markovic
  • Use of peptide analogs of thrombospondin for the inhibition of angiogenic activity
    Patent number: 5200397
    Abstract: Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: April 6, 1993
    Assignees: W. R. Grace & Co.-Conn., The Medical College of Pennsylvania
    Inventors: Alan H. Deutch, George P. Tuszynski
  • Peptide fragments and analogs of thrombospondin and methods of use
    Patent number: 5190918
    Abstract: Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: March 2, 1993
    Assignees: W. R. Grace & Co.-Conn., The Medical College of Pennsylvania
    Inventors: Alan H. Deutch, George Tuszynski
  • Use of thrombospondin to promote wound healing
    Patent number: 5155038
    Abstract: Pharmaceutical compositions and dressings useful in wound healing are provided. The pharmaceutical compositions comprise thrombospondin as the active ingredient.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: October 13, 1992
    Assignees: W. R. Grace & Co.-Conn., Medical College of Pennsylvania
    Inventors: Jacob Eyal, George Tuszynski