Abstract: Disclosed herein are devices, methods and systems for monitoring and detection of adverse events in a subject. In an embodiment, an insulin delivery device includes an insulin injection device in communication with a controller for controlling the insulin injection device. The controller is configured to receive a heart signal from one or more heart sensors, and a blood glucose signal from one or more blood glucose sensors. The controller is further configured to analyze changes in the heart rhythm of the subject based on the heart signal and determine, based on the changes in the heart rhythm and the blood glucose signal, whether the subject is and/or will be experiencing an adverse event. Upon determination that the subject is or will be experiencing an adverse event, the controller determines one or more parameters of delivery of insulin to be delivered to the subject.

Abstract: Devices, methods and systems for predicting and detecting a change in a physiological condition of a subject are disclosed. A device for detecting and predicting a change in physiological condition of a subject may include one or more processors configured to: (i) analyze changes in a heart rhythm of a subject; (ii) analyze a signal from one or more biomarkers that are associated with a physiological condition of the subject; and (iii) determine, based on the changes in the heart rhythm and the signal from the one or more biomarkers, whether there is a change in the physiological condition of the subject during a time period.

Abstract: Devices, methods and systems for predicting and detecting a change in a physiological condition of a subject are disclosed. A device for detecting and predicting a change in physiological condition of a subject may include one or more processors configured to: (i) analyze changes in a heart rhythm of a subject; (ii) analyze a signal from one or more biomarkers that are associated with a physiological condition of the subject; and (iii) determine, based on the changes in the heart rhythm and the signal from the one or more biomarkers, whether there is a change in the physiological condition of the subject during a time period.

Abstract: The invention relates to a method and device for recording and presentation of physiological parameters, which can include both blood pressure and heart pulse. Information about the heart pulse is derived from a recorded blood pressure signal, whereby the need for e.g. an external ECG measurement device is eliminated. It is likewise a part of the invention that a blood pressure measurement is used for the derivation of data such as Heart Rate Variability (HRV) and/or baroreflex sensitivity (BRS) values.