Patents Assigned to Medistem Laboratories
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Publication number: 20130156726Abstract: The invention provides pluripotent stem cells and methods for making and using pluripotent stem cells. Pluripotent stem cells, among other things, can differentiate into various cell lineages in vitro, ex vivo and in vivo. Pluripotent stem cells, among other things, can also be used to produce conditioned medium.Type: ApplicationFiled: June 15, 2012Publication date: June 20, 2013Applicant: MediStem Laboratories, Inc.Inventors: THOMAS E. ICHIM, XIAOLONG MENG, NEIL H. RIORDAN
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Publication number: 20120269774Abstract: Methods, cells, and compositions of matter are disclosed for performing stem cell transplants in patients that have not been previously immunosuppressed. Specific disclosed are methods of matching, methods of treating the stem cell graft, and use of engraftment-assisting cells and agents.Type: ApplicationFiled: September 20, 2007Publication date: October 25, 2012Applicant: MEDISTEM LABORATORIES, INCInventors: Thomas E. Ichim, Neil H. Riordan
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Patent number: 8241621Abstract: Disclosed are cells, methods of modulating cells, and therapeutic uses of the cells for the immune modulation of mammals in need thereof. Immune modulation including alteration of cytokine profile, cytotoxic activity, antibody production and inflammatory states is achieved through the administration of various cell types that have been unmanipulated or manipulated in order to endow specific biological activity. Cellular subsets and administration of the subsets in combination with various agents are also provided. One embodiment teaches the previously unknown finding that adipose tissue derived mononuclear cells contain T cells with immune regulatory properties that alone or synergistically with various stem cells induce immune modulation upon administration. Another embodiment is the finding that stimulation of stem cell activation results in stem cell secondary activation of immune modulatory cells, one type which is T regulatory cells (Tregs).Type: GrantFiled: December 18, 2007Date of Patent: August 14, 2012Assignee: Medistem LaboratoriesInventor: Thomas E. Ichim
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Publication number: 20110104100Abstract: Disclosed are methods, compositions of matter, and cells, useful for the treatment of autism, social integrative disorders, and various cognitive abnormalities. The invention discloses, inter alia, means of substantially ameliorating or reversing the progression of autism through the administration of autologous and/or allogeneic stem cells, alone or in combination with mobilization agents. The use of stem cells and cells naturally possessing or endowed with angiogenic and anti-inflammatory activity are disclosed for autism either alone or in combination with various therapeutic interventions.Type: ApplicationFiled: October 3, 2008Publication date: May 5, 2011Applicant: MEDISTEM LABORATORIES, INC.Inventors: Neil H. Riordan, Thomas E. Ichim
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Publication number: 20110070313Abstract: Disclosed are methods of preparing and using placentally-derived stem cells and compositions useful for the treatment of cancer. Said stem cells and compositions function through inducing a “guided differentiation” program in cancer cells, thereby reducing malignancy. Further extension of the invention pertains to augmenting ability of administered cells to induce differentiation through the co-administration of known differentiation inducing agents. Within the context of this disclosure, methods for inducing host responses to cancer are also described.Type: ApplicationFiled: November 29, 2010Publication date: March 24, 2011Applicant: MEDISTEM LABORATORIES, INC.Inventor: Thomas E. Ichim
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Publication number: 20100261152Abstract: A method of increasing the growth of stem cells by mixing the stem cells with a growth medium that has been conditioned by an incubation with placental tissue. The method increases the expansion of the stem cell population.Type: ApplicationFiled: June 25, 2010Publication date: October 14, 2010Applicant: MEDISTEM LABORATORIES, INC.Inventor: Neil H. Riordan
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Publication number: 20100008992Abstract: Methods and compositions for treating or ameliorating lower back pain by administering an effective amount of one or more cell types, alone, and/or in combination with a matrix, and/or in combination with growth factors, in order to stimulate lumbar angiogenesis, decrease inflammation, and stimulating regeneration.Type: ApplicationFiled: May 18, 2007Publication date: January 14, 2010Applicant: Medistem Laboratories, Inc.Inventor: Thomas E. Ichim
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Publication number: 20090311223Abstract: Methods, cells and compositions of matter are provided for treatment of erectile dysfunction using stem cell therapy. In particular, various stem cells are modified or administered freshly isolated in order to induce smooth muscle regeneration, neural regeneration, and restoration of endothelial function. In some embodiments endogenous stem cells are mobilized or activated to achieve therapeutic benefit. In other embodiments compositions derived from stem cells are utilized for treatment of erectile dysfunction.Type: ApplicationFiled: June 22, 2007Publication date: December 17, 2009Applicant: MEDISTEM LABORATORIES, INCInventor: Thomas E. Ichim
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Publication number: 20090053182Abstract: The invention provides pluripotent stem cells and methods for making and using pluripotent stem cells. Pluripotent stem cells, among other things, can differentiate into various cell lineages in vitro, ex vivo and in vivo. Pluripotent stem cells, among other things, can also be used to produce conditioned medium.Type: ApplicationFiled: May 27, 2008Publication date: February 26, 2009Applicant: MediStem Laboratories, Inc.Inventors: THOMAS E. ICHIM, Xiaolong Meng, Neil H. Riordan