Patents Assigned to Medstar Health Research Institute, Inc.
  • Patent number: 10674943
    Abstract: A non-invasive system, and method for simple, quantitative screening for mTBI and other forms of mid cognitive impairment using a visuo-motor performance test (for example, a submaximal grip test) in response to visual feedback to quantitatively measure the intra-individual variability of performance metric for initial screening of patients with mild traumatic brain injury (mTBI), and other neurological disorders. The system and method can be administered in minutes, by any level of caregiver, in any environment including military in-the-field or sports on-field deployments, and is useful in screening those truly injured from those disguising or mimicking injury. In addition to screening, the system and method can be used to monitor and/or detect changes to intra-individual variability over time by comparison to a baseline, which in turn is helpful in determining estimated recovery trajectory or other related information.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: June 9, 2020
    Assignees: MEDSTAR HEALTH RESEARCH INSTITUTE, INC., GEORGETOWN UNIVERSITY
    Inventors: Alexander Dromerick, Peter S. Lum, Rochelle E. Tractenberg
  • Patent number: 8911963
    Abstract: Described herein are conditioned medium and processed conditioned medium, each of which comprises secreted stem cell factors; compositions containing conditioned medium and/or processed conditioned medium and a delivery polymer. The conditioned medium, processed conditioned medium and compositions may be used to promote blood vessel growth and healing of injured tissues.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: December 16, 2014
    Assignee: MedStar Health Research Institute, Inc.
    Inventors: Stephen E. Epstein, Mary Susan Burnett, Amir Najafi
  • Patent number: 8853378
    Abstract: Described herein are homing polypeptides that home to atherosclerotic plaque(s) in mammals and nucleic acids that encode such polypeptides. Also described are methods for detecting and treating conditions or disorders associated with, or characterized, by elevated levels of homing polypeptides that home to atherosclerotic plaque and/or vulnerable plaque.
    Type: Grant
    Filed: October 9, 2010
    Date of Patent: October 7, 2014
    Assignees: Georgetown University, MedStar Health Research Institute, Inc.
    Inventors: Anton Wellstein, Stephen E. Epstein, Mary Susan Burnett
  • Publication number: 20140066384
    Abstract: Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia.
    Type: Application
    Filed: April 15, 2013
    Publication date: March 6, 2014
    Applicants: MedStar Health Research Institute, Inc., Georgetown University
    Inventors: Anton Wellstein, Marcel O. Schmidt, Stephan Zbinden, Mary Susan Burnett, Stephen E. Epstein
  • Publication number: 20130110132
    Abstract: Described herein are conditioned medium and processed conditioned medium, each of which comprises secreted stem cell factors; compositions containing conditioned medium and/or processed conditioned medium and a delivery polymer. The conditioned medium, processed conditioned medium and compositions may be used to promote blood vessel growth and healing of injured tissues.
    Type: Application
    Filed: April 5, 2011
    Publication date: May 2, 2013
    Applicant: MedStar Health Research Institute, Inc.
    Inventors: Stephen E. Epstein, Mary Susan Burnett, Amir Najafi
  • Patent number: 8420590
    Abstract: Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: April 16, 2013
    Assignees: Georgetown University, MedStar Health Research Institute, Inc.
    Inventors: Anton Wellstein, Marcel O. Schmidt, Stephan Zbinden, Mary Susan Burnett, Stephen E. Epstein
  • Publication number: 20120269731
    Abstract: Described herein are homing polypeptides that home to atherosclerotic plaque(s) in mammals and nucleic acids that encode such polypeptides. Also described are methods for detecting and treating conditions or disorders associated with, or characterized, by elevated levels of homing polypeptides that home to atherosclerotic plaque and/or vulnerable plaque.
    Type: Application
    Filed: October 9, 2010
    Publication date: October 25, 2012
    Applicants: Medstar Health Research Institute, Inc., Georgetown University
    Inventors: Anton Wellstein, Stephen E. Epstein, Mary Susan Burnett