Abstract: A non-invasive system, and method for simple, quantitative screening for mTBI and other forms of mid cognitive impairment using a visuo-motor performance test (for example, a submaximal grip test) in response to visual feedback to quantitatively measure the intra-individual variability of performance metric for initial screening of patients with mild traumatic brain injury (mTBI), and other neurological disorders. The system and method can be administered in minutes, by any level of caregiver, in any environment including military in-the-field or sports on-field deployments, and is useful in screening those truly injured from those disguising or mimicking injury. In addition to screening, the system and method can be used to monitor and/or detect changes to intra-individual variability over time by comparison to a baseline, which in turn is helpful in determining estimated recovery trajectory or other related information.
Type:
Grant
Filed:
September 6, 2013
Date of Patent:
June 9, 2020
Assignees:
MEDSTAR HEALTH RESEARCH INSTITUTE, INC., GEORGETOWN UNIVERSITY
Inventors:
Alexander Dromerick, Peter S. Lum, Rochelle E. Tractenberg
Abstract: Described herein are conditioned medium and processed conditioned medium, each of which comprises secreted stem cell factors; compositions containing conditioned medium and/or processed conditioned medium and a delivery polymer. The conditioned medium, processed conditioned medium and compositions may be used to promote blood vessel growth and healing of injured tissues.
Type:
Grant
Filed:
April 5, 2011
Date of Patent:
December 16, 2014
Assignee:
MedStar Health Research Institute, Inc.
Inventors:
Stephen E. Epstein, Mary Susan Burnett, Amir Najafi
Abstract: Described herein are homing polypeptides that home to atherosclerotic plaque(s) in mammals and nucleic acids that encode such polypeptides. Also described are methods for detecting and treating conditions or disorders associated with, or characterized, by elevated levels of homing polypeptides that home to atherosclerotic plaque and/or vulnerable plaque.
Type:
Grant
Filed:
October 9, 2010
Date of Patent:
October 7, 2014
Assignees:
Georgetown University, MedStar Health Research Institute, Inc.
Inventors:
Anton Wellstein, Stephen E. Epstein, Mary Susan Burnett
Abstract: Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia.
Type:
Application
Filed:
April 15, 2013
Publication date:
March 6, 2014
Applicants:
MedStar Health Research Institute, Inc., Georgetown University
Inventors:
Anton Wellstein, Marcel O. Schmidt, Stephan Zbinden, Mary Susan Burnett, Stephen E. Epstein
Abstract: Described herein are conditioned medium and processed conditioned medium, each of which comprises secreted stem cell factors; compositions containing conditioned medium and/or processed conditioned medium and a delivery polymer. The conditioned medium, processed conditioned medium and compositions may be used to promote blood vessel growth and healing of injured tissues.
Type:
Application
Filed:
April 5, 2011
Publication date:
May 2, 2013
Applicant:
MedStar Health Research Institute, Inc.
Inventors:
Stephen E. Epstein, Mary Susan Burnett, Amir Najafi
Abstract: Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia.
Type:
Grant
Filed:
November 30, 2007
Date of Patent:
April 16, 2013
Assignees:
Georgetown University, MedStar Health Research Institute, Inc.
Inventors:
Anton Wellstein, Marcel O. Schmidt, Stephan Zbinden, Mary Susan Burnett, Stephen E. Epstein
Abstract: Described herein are homing polypeptides that home to atherosclerotic plaque(s) in mammals and nucleic acids that encode such polypeptides. Also described are methods for detecting and treating conditions or disorders associated with, or characterized, by elevated levels of homing polypeptides that home to atherosclerotic plaque and/or vulnerable plaque.
Type:
Application
Filed:
October 9, 2010
Publication date:
October 25, 2012
Applicants:
Medstar Health Research Institute, Inc., Georgetown University
Inventors:
Anton Wellstein, Stephen E. Epstein, Mary Susan Burnett