Abstract: A delivery catheter (1), an implant delivery system and methods of operation. A balloon structure in the delivery catheter (1) includes an expandable component and a balloon body (140). The expandable component is disposed within the balloon body (140) so as to be expandable therein. Moreover, the expandable component is sleeved over a distal end of a guidewire tube (210). An implant is disposed over the balloon body (140) and axially restrained over a middle portion of the expandable component during delivery. The expandable component is configured to provide a radially outward support force from a middle portion of the balloon body (140) during expansion so as to bring internal environments of the balloon body (140) respectively at distal and proximal end thereof into communication. This facilitates stable and uniform and hence symmetric expansion of the implant.

Abstract: A power unit for supplying electric energy to at least one electrode of an electronic apparatus for delivering Coherent Sine Burst Irreversible Electroporation energy, including at least one power module to generate an electric signal (S) to energize one or more respective electrodes, the power module comprising a selecting block configured to receive at least one square wave input signal and continuously change the electric energy level associated with said electric signal (S) based on the at least one square wave input signal in order to provide a combined signal at an output of the selecting block, wherein the combined signal comprises a square wave waveform; and a filtering and electrical isolation block configured to convert the combined signal into a sine wave signal and to filter the sine wave signal to generate the electric signal (S), wherein the conversion and filtering are electrically isolated from one another.

Abstract: A therapeutic device, therapeutic system and therapeutic method for myocardium repair, wherein the therapeutic device comprises a treatment needle for piercing the heart to release a therapeutant. The treatment needle includes a needle body (5a), the interior of the needle body (5) has a therapeutant conveying cavity, an end of the needle body (5a) is a needle (5b) which can pierce the myocardium and guide the needle body (5a) to pass through the myocardium, and the needle (5b) has a therapeutant output port which is connected to the therapeutant conveying cavity. The therapeutic device enters into the myocardium in a minimally invasive manner to release the therapeutant to the vicinity of the lesion to improve myocardial function or activity and prevent further deterioration of the disease.

Abstract: Provided herein is a method of treating, preventing, or alleviating one or more symptoms of Chagas disease in a subject, comprising administering to the subject (i) ascorbic acid, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; and (ii) a quinone compound, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

Abstract: A valve leaflet obstruction repair clip and a repair system thereof include a clamping component and a flow obstruction component. The clamping component and the flow obstruction component are assembled and clamped to fix the incomplete closure between the valve leaflets. The upper clamping arm and the lower clamping arm are engaged together in a natural state, and the upper clamping arm undergoes unilateral movement in an extended state. The present application enables edge-to-edge repair of the valve leaflets and adopts unilateral clamping, effectively preventing the problem of valve leaflet stenosis caused by the implantation of the repair device.

Abstract: A device for the non-invasive treatment of muscular and neuromuscular pathologies by applying a succession of mechanical-sound waves to a muscle.

Abstract: The present disclosure provides a neutron capture therapy system, including an accelerator for generating a charged particle beam, a neutron generator for generating a neutron beam having neutrons after irradiation by the charged particle beam, and a beam shaping assembly for shaping the neutron beam. The beam shaping assembly includes a moderator and a reflecting assembly surrounding the moderator. The neutron generator generates the neutrons after irradiation by the charged particle beam. The moderator moderates the neutrons generated by the neutron generator to a preset energy spectrum. The reflecting assembly includes a reflecting assembly to deflected neutrons back to the neutron beam and a supporting member to support the reflectors. A lead-antimony alloy is for the reflecting assembly to mitigate a creep effect that occurs when only a lead material is for the reflectors, thereby improving the structural strength of a beam shaping assembly.

Abstract: An adjustable suture locking apparatus includes a lock pin, an outer tube, a handle, and an adjusting device. The lock pin is used to receive or fix a suture. The outer tube defines a receiving cavity. The lock pin is disposed at a distal end of the receiving cavity. The handle includes a fixing portion coupled to a proximal end of the outer tube. The adjusting device is disposed on the fixing portion. The adjusting device is coupled to a proximal end of the suture and operable to adjust tensioning or loosening of the suture.

Abstract: This invention concerns an automated registration method and device for a surgical robot enabling registration between a first three-dimensional location system comprising an optical distance sensor and a second three-dimensional location system comprising optical acquisition means. The method comprises: a first step of intraoperative registration between the first location system and data recorded on an anatomical surface of a patient and; a second step of intraoperative registration of two three-dimensional location systems. The second registration step is performed at the same time as the first registration step by detection, by the optical acquisition means, of at least one point of a point cloud acquired by the optical sensor during the first intraoperative registration.

Abstract: A stent including a hybrid network cluster of open cells and closed cells arranged wherein said closed cells are connected in a configuration to be resheathable. Open cells are not connected and the stent can be unsheathed to enhance flexibility. In one embodiment a ring of proximal closed cells are tapered and the stent is retrievable by engagement of a pushwire assembly.

Abstract: A method of treating or cleaning a wound bed is disclosed. The method includes obtaining a wound-care device. The wound-care device includes a handle and a head monolithically formed with a first end of the handle and extending away from the first end of the handle. The head includes a base and a plurality of projections monolithically formed with the base and extending away from the base. During use of the wound-care device, a user may manually disturb a wound bed of a patient by placing one or more projections of the plurality of projections in contact with the wound bed and manually moving, while the one or more projections are in contact with the wound bed, the wound-care device with respect to the wound bed.

Abstract: The present application provides a valve annulus contraction surgical system with an adjustable annulus contracting force at a single point, and relates to the technical field of medical devices. The system includes a plurality of anchors, an implantation device, a plurality of groups of locking sutures and a suture locking device. A suture locking tab is arranged on at least one of two sides of each of the anchors. The implantation device is configured to implant the anchors into a valve annulus; each group of locking sutures includes a first locking suture and a second locking suture for connection with the suture locking tab. The suture locking device is configured to lock and fix the other end of the first locking suture and the other end of the second locking suture. In the present application, a valve orifice can be completely covered by a valve, thereby ensuring a therapeutic effect.

Abstract: An anchoring device for a cardiac valve is disclosed. The anchoring device includes a ventricular section (1), the ventricular section (1) includes an anchoring segment (11) and a capture segment (12), the anchoring segment (11) is in the form of a helical coil, a radius of curvature of the helical coil is constant and a distance between turns of the helical coil is the same, and the anchoring device does not include an atrial section. The anchoring device is made of an elastic material. The design of the anchoring device separating from the valve can provide an anchoring effect while allowing a delivery sheath of an associated delivery system to have a reduced radial dimension. During release of the anchoring device, the capture segment (12) can automatically capture the native leaflets or chordae tendineae. It is a modification of an existing anchor ring and dispenses with the use of a guide wire.

Abstract: A stent delivery system comprising a balloon catheter having a catheter shaft with a balloon mounted on a distal end with a self-expanding stent positioned on the catheter shaft proximal to the balloon (tandemly) with a delivery sheath covering the self-expanding stent. In use, the stent delivery system is advanced on the guidewire to the target lesion and the balloon is inflated to dilate the lesion. The balloon is deflated and advanced distally past the lesion until the self-expanding stent positioned proximate the lesion. The sheath is withdrawn, releasing the self-expanding stent to expand and contact the lesion. Once the self-expanding stent has expanded, the stent delivery system and guidewire are withdrawn from the lesion.

Abstract: A system and method for pre-operative or intra-operative surgical procedure feedback provide a recommendation to a surgeon. A system may include a robotic surgical device to perform a portion of a surgical procedure on a patient, and a processor to determine a recommendation, based on past surgical information, for the portion of the surgical procedure performed by the robotic surgical device or for a next action to be taken, but the robotic surgical device or a surgeon. The system may include outputting the recommendation by intra-operatively providing the recommendation to a surgeon operating the robotic surgical device.

Abstract: The present invention describes systems and methods using a detachment coupler mechanism of an implant assembly in delivering and detaching an implant at a target site or location within the neurovascular space/body of patient.

Abstract: An implant delivery handle, an implant system, a delivery system and a method of use thereof are disclosed. Transmission systems in the implant delivery handle each include a lead screw, an inner tube coupling member, an outer gear and an inner gear. The outer gear rotatably engages the inner gear and is configured to drive rotation of the inner gear. The lead screw is coupled to a first inner tube (11) or a second inner tube (12) through the inner tube coupling member. The lead screw also engages the inner gear and rotates therewith to cause axial movement of the first inner tube (11) or the second inner tube (12). A transmission ratio of the outer gear to the inner gear is greater than 1.

Abstract: A device for temporarily protecting a neck of an aneurysm of a blood vessel is provided. The device includes a plurality of wires coiled to form a collapsible frame configured to expand and substantially conform to a shape of an inside surface of the blood vessel while the aneurysm is being treated. The device includes a retention wire disposed at a proximal end of the frame of the plurality of wires. The device includes a cover comprising at least a first portion configured to be disposed directly against a neck of the aneurysm while the aneurysm is being treated, the first portion having a first porosity to blood flow. Related methods of use and manufacturing are also provided.

Abstract: A valve leaflet obstruction repair clip and a repair system thereof include a clamping component and a flow obstruction component. The clamping component and the flow obstruction component are assembled and clamped to fix the incomplete closure between the valve leaflets. The upper clamping arm and the lower clamping arm are engaged together in a natural state, and the upper clamping arm undergoes unilateral movement in an extended state. The present application enables edge-to-edge repair of the valve leaflets and adopts unilateral clamping, effectively preventing the problem of valve leaflet stenosis caused by the implantation of the repair device.