Abstract: In many aspects, the invention relates to systems and methods for providing cognitive therapy through stimulation of activating and inhibiting neurons in the brain, thereby modulating neural firing rhythms. The stimulation of neurons is controlled through a feedback process whereby neuron firing rhythms are altered based on naturally occurring electrical and chemical activity in the brain. Neurons in specific regions of the brain may be targeted in order to establish neural signaling pathways and establish communication between these regions.

Abstract: An invasive device that uses electrodes in conjunction with ultrasound is used to enhance and localize electrical recordings and stimulation of neurons. The current design is confined to operate within an elongated geometry for ease of insertion and minimal disruption to brain tissue.

Abstract: In many aspects, the invention relates to systems and methods for providing memory therapy by modulating neural firing rhythms, in particular in Alzheimer's patients. The stimulation of neurons is controlled through a feedback process whereby neuron firing rhythms are altered based on naturally occurring electrical and chemical activity in the brain. Neurons in the nucleus basalis and dentate gyrus may be targeted in order to establish neural signaling pathways and establish communication between these regions.

Abstract: In many aspects, the invention relates to systems and methods for providing cognitive therapy through stimulation of activating and inhibiting neurons in the brain, thereby modulating neural firing rhythms. The stimulation of neurons is controlled through a feedback process whereby neuron firing rhythms are altered based on naturally occurring electrical and chemical activity in the brain. Neurons in specific regions of the brain may be targeted in order to establish neural signaling pathways and establish communication between these regions.

Abstract: A multi-channel neuromodulation electrode assembly has multiple electrodes arranged in a non-linear, non-planar fashion by stacking electrode elements to form an electrode stack. Multiple electrode stacks may be combined to produce electrode shanks, and multiple electrode shanks may be combined to produce electrode arrays. This provides an easily customizable non-linear and non-planar channel arrangement. Complex electrode configurations can be assembled from multiple electrode elements. Depending on the requirements, the number of channels, the channel spacing, the complexity of assembly differs. In one embodiment, referred to as a “Christmas tree” configuration, the electrode has two stacks facing opposite directions. In another embodiment, referred to as an “Empire State Building” configuration, the electrode has four stacks facing different directions. In yet another embodiment, the electrode has eight stacks facing different directions.