Patents Assigned to Meiji Seika Kaisha, Ltd.
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Patent number: 7893254Abstract: A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto.Type: GrantFiled: June 3, 2005Date of Patent: February 22, 2011Assignees: Otsuka Chemical Co., Ltd., Meiji Seika Kaisha Ltd.Inventors: Yoichi Nishioka, Masahiro Ito, Yutaka Kameyama
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Patent number: 7879808Abstract: An objective of the present invention is to provide compounds of formula (1) or their pharmacologically acceptable salts or solvates wherein A represents aryl; R1 represents N-optionally substituted C1-6 alkyl-N-optionally substituted C1-6 alkylamino-C1-6 alkyl; R2 represents a hydrogen atom or optionally substituted C1-6 alkyl; R3 represents optionally substituted C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; m is 1 to 3; n is 0; and p is 0 to 2. The compounds are novel lincomycin derivatives that have a potent activity against resistant Streptococcus pneumoniae, which have recently posed problems, in the treatment of infectious diseases. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.Type: GrantFiled: May 30, 2008Date of Patent: February 1, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yoshinari Wakiyama, Kou Kumura, Satomi Masaki, Kazutaka Ueda, Yasuo Sato, Chika Kikuchi, Eijirou Umemura, Yoko Hirai, Hiroshi Kondo
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Patent number: 7880006Abstract: Disclosed are compounds that have excellent insecticidal activity and are usable as agricultural and horticultural insecticides. Compounds represented by formula (I) or agriculturally and horticulturally acceptable acid addition salts thereof have excellent insecticidal activity and are usable as agricultural and horticultural insecticides.Type: GrantFiled: August 3, 2005Date of Patent: February 1, 2011Assignees: Meiji Seika Kaisha, Ltd., Nippon Kayaku Co., Ltd.Inventors: Kazumi Yamamoto, Ryo Horikoshi, Kazuhiko Oyama, Hiroshi Kurihara, Shizuo Shimano, Takaaki Miyake, Hiroki Hotta, Jun Iwabuchi
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Patent number: 7871982Abstract: This invention provides compounds of formula (I) or its pharmacologically acceptable salt or solvate, wherein A represents aryl or a monocyclic or bicyclic heterocyclic group, R1 represents a halide, nitro, substituted C1-6 alkyl, optionally substituted amino, C1-6 alkyloxycarbonyl, optionally substituted aryl, a heterocyclic group, or heterocyclic carbonyl, R2 represents a hydrogen atom or C1-6 alkyl, R3 represents C1-6 alkyl, all of R4, R5, and R6 represent a hydrogen atom, R7 represents C1-6 alkyl, m is 1 or 2, and n is 1. The compounds are novel lincomycin derivatives having a potent activity against resistant pneumococci. The compounds can be used as an antimicrobial agent and are useful for preventing or treating bacterial infectious diseases.Type: GrantFiled: December 11, 2006Date of Patent: January 18, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Eijirou Umemura, Yoshinari Wakiyama, Kazutaka Ueda, Kou Kumura, Satomi Masaki, Takashi Watanabe, Mikio Yamamoto, Chizuko Kaji, Keiichi Ajito
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Publication number: 20110009662Abstract: A process for efficiently producing through a small number of steps an N-substituted 2-amino-4-(substituted-oxymethylphosphinyl)-2-butenoic ester which is an intermediate for herbicide L-AMPB. The process comprises reacting a compound represented by the following formula (1): (where R1 represents C1-4 alkyl group) with a compound represented by the following formula (2): (wherein R2, R2?, and R3 each represents C1-4 alkyl and R4 represents benzyloxycarbonyl) in the presence of a base.Type: ApplicationFiled: March 19, 2008Publication date: January 13, 2011Applicant: MEIJI SEIKA KAISHA LTD.Inventors: Kenichi Kurihara, Nobuto Minowa, Nozomu Nakanishi, Masaaki Mitomi
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Patent number: 7867980Abstract: An objective of the present invention is to provide compounds of formula (I) or their pharmacologically acceptable salts or solvates wherein A represents aryl while R1 represents a five- or six-membered monocyclic heterocyclic group, or A represents a four- to six-membered monocyclic heterocyclic group while R1 represents aryl or a five- or six-membered monocyclic heterocyclic group; R2 represents a hydrogen atom or C1-6 alkyl; R3 represents C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; R4, R5, and R6 represent a hydrogen atom; R7 represents C1-6 alkyl; and m is 1 to 3. The compounds are novel lincosamide derivatives that have a potent activity against resistant Streptococcus pneumoniae. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.Type: GrantFiled: May 30, 2008Date of Patent: January 11, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Eijirou Umemura, Kou Kumura, Satomi Masaki, Kazutaka Ueda, Yoshinari Wakiyama, Yasuo Sato, Mikio Yamamoto, Keiichi Ajito, Takashi Watanabe, Chizuko Kaji
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Publication number: 20110003834Abstract: An object is to provide a method for producing a high theobromine-containing composition effectively in a simple way. The method for producing a theobromine-containing composition comprises: (a) performing an extraction of a theobromine-containing plant or a processed product thereof with a solvent, to obtain a crude theobromine extract; (b) applying the crude theobromine extract to a cation exchange resin subjected in advance to hydrogen ion substitution, to allow an adsorption of theobromine onto the cation exchange resin; and (c) passing a solvent containing no ionic substance through the cation exchange resin subsequently to the step (b), to obtain a theobromine eluate.Type: ApplicationFiled: February 6, 2009Publication date: January 6, 2011Applicant: MEIJI SEIKA KAISHA, LTD.Inventors: Satoshi Hanamura, Ken Chikauchi, Shigeru Kanazawa, Jinichiro Koga, Minoru Kanegae
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Patent number: 7863248Abstract: A tyrosinase activity inhibitor and an ameliorant for facial blood flow that are excellent in terms of safety, and medicinal compositions, food compositions, and cosmetic preparations that contain the inhibitor and the ameliorant as active ingredients are provided. A tyrosinase activity inhibitor and an ameliorant for facial blood flow that contain anthocyan obtained by concentration or extraction of plant material, and medicinal compositions, food compositions, and cosmetic preparations that have an inhibitory action on tyrosinase activity and ameliorating action on facial blood flow are provided.Type: GrantFiled: October 20, 2004Date of Patent: January 4, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Hitoshi Matsumoto, Yuko Nakamura, Megumi Yamagishi, Kyoko Ito
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Publication number: 20100330100Abstract: An object is to provide: a protein antigen or a peptide antigen usable as a vaccine composition which has an ability to practically prevent or treat a Pseudomonas aeruginosa infection, and which can cope with the diversity of clinical isolates derived from patients with a Pseudomonas aeruginosa infection; and an antibody directed against the antigen. The present invention provides a protein antigen or a peptide antigen and an antibody directed against these, which are for use in diagnosis, prevention, or treatment of a disease associated with Pseudomonas aeruginosa. According to the present invention, a protein or a peptide derived from a Pseudomonas aeruginosa-outer membrane protein PA4710, and an antibody directed against these are provided, which are for use in diagnosis, prevention, or treatment of a disease associated with Pseudomonas aeruginosa.Type: ApplicationFiled: June 30, 2008Publication date: December 30, 2010Applicant: Meiji Seika Kaisha Ltd.Inventors: Jiro Tanaka, Hiroshi Nagaso, Masashi Kumagai, Keiko Otsuka, Hirotomo Akabane, Takahisa Suzuki
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Patent number: 7858612Abstract: The present invention relates to a method for maintaining the remission of or treating inflammatory bowel diseases, which comprises administering a maintenance therapeutically effective amount or a therapeutically effective amount of 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzoazepine, a prodrug thereof, or a pharmaceutically acceptable salt thereof to a mammal, wherein the prodrug is 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine. The method according to the present invention is effective in the maintenance therapy and therapy of the inflammatory bowel diseases and has few side effects. Particularly, the method according to the present invention may exhibit strong maintenance therapeutic and therapeutic effects, even on severe cases having resistance to the conventional therapeutics.Type: GrantFiled: December 17, 2008Date of Patent: December 28, 2010Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tomohisa Ninomiya, Takashi Shishikura, Mitsuhiro Uchida, Sho Takahata, Yukari Hoshina, Ken-ichi Kawano
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Patent number: 7838538Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:Type: GrantFiled: December 23, 2008Date of Patent: November 23, 2010Assignees: Meiji Seika Kaisha, Ltd., The Kitasato InstituteInventors: Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
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Publication number: 20100291070Abstract: An object is to provide an antibody and a vaccine composition which have an ability to practically prevent or treat a Pseudomonas aeruginosa infection, and which can cope with the diversity of clinical isolates derived from patients infected with Pseudomonas aeruginosa. According to the present invention, an antibody against a PA1698 protein that is a type III secretion system component protein of Pseudomonas aeruginosa or against a peptide of the protein, and a vaccine composition comprising the protein or the peptide are provided.Type: ApplicationFiled: December 24, 2008Publication date: November 18, 2010Applicant: MEIJI SEIKA KAISHA, LTD.Inventors: Masashi Kumagai, Jiro Tanaka, Hiroshi Nagaso, Tomohisa Ninomiya, Keiko Otsuka, Hirotomo Akabane, Takahisa Suzuki
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Patent number: 7833557Abstract: The method of impregnation treatment for foods comprises impregnating the foods with a liquid component or a gas component by contacting the foods with the liquid component or the gas component after vacuum treatment or in the vacuum state and/or cooling the foods in contact with the liquid component. The method of impregnation treatment for foods of the present invention enables readily impregnating various kinds of foods with various liquid components or gas components. The invention also provides a vitamin C-containing egg and a pidan-like egg.Type: GrantFiled: November 14, 2006Date of Patent: November 16, 2010Assignee: Meiji Seika Kaisha, Ltd.Inventors: Munehiko Kuwa, Soichiro Kuwa, Kiyoshi Yamano
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Publication number: 20100255543Abstract: Disclosed is a transformant prepared by introducing a ketoreductase gene involved in the biosynthesis of L-epivancosamine into an actinobacterium originally capable of producing daunorubicin. Also disclosed is a process of efficiently producing a non-natural daunorubicin derivative using the transformant. The transformant is capable of efficiently producing a non-natural daunorubicin derivative such as epidaunorubicin.Type: ApplicationFiled: September 12, 2008Publication date: October 7, 2010Applicant: MEIJI SEIKA KAISHA, LTDInventors: Naomi Sumida, Manabu Watanabe, Koji Yanai
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Patent number: 7795001Abstract: The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein the protein contains an amino acid sequence selected from SEQ ID NOs: 2 to 10, 13, 14, 16, 19, 20, 22 to 26, and 28 to 38 or a modified amino acid sequence of the amino acid sequence having one or more amino acid modifications without affecting activity of the protein.Type: GrantFiled: January 12, 2006Date of Patent: September 14, 2010Assignee: Meiji Seika Kaisha, Ltd.Inventors: Naoki Midoh, Shigeru Hoshiko, Takeshi Murakami
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Patent number: 7795464Abstract: A method for efficiently producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid, useful as a herbicide, by a catalytic asymmetric synthesis reaction with a high asymmetric yield. The method includes a step in which a compound represented by the below formula (1) and a benzylamine are reacted in the presence of dehydrating agent, then the resulting mass is reacted with hydrogen cyanide in the presence of an asymmetric catalyst, followed by acid hydrolysis, further followed by elimination of a protective group. [chemical formula 1] (1) (where, R1 represents a C1-4 alkyl group).Type: GrantFiled: September 19, 2007Date of Patent: September 14, 2010Assignee: Meiji Seika Kaisha Ltd.Inventors: Nobuto Minowa, Nozomu Nakanishi, Masaaki Mitomi
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Patent number: 7790430Abstract: Disclosed is a novel cellulose having an amino acid sequence in which the 162nd and/or 166th amino acid residues in the amino acid sequence of cellulose NCE5 are substituted. Further, a polynucleotide encoding the novel cellulose, an expression vector containing the polynucleotide, a host cell transformed with the expression vector, and a cellulose preparation and a washing composition containing the cellulose are disclosed. The cellulose of the present invention is resistant to surfactants, and maintains a high activity even under alkaline conditions.Type: GrantFiled: April 11, 2008Date of Patent: September 7, 2010Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kaoru Okakura, Koji Yanai
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Patent number: 7790425Abstract: The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide encoding such a protein, and a method of producing soyasapogenol B on a large scale using the same. A protein according to the present invention are concerned with (a), (b) or (c), namely (a) a protein comprising an amino acid sequence selected from the group consisting of the amino acid sequences shown in SEQ ID NOs: 2, 4, and 6; (b) a protein that has at least 50% homology to the protein comprising the amino acid sequence of the sequence described in (a) and having saponin-decomposing activity; or (c) a protein comprising a modified amino acid sequence of the sequence described in (a) that has one or more amino acid residues deleted, substituted, inserted, or added and having saponin-decomposing activity.Type: GrantFiled: November 24, 2009Date of Patent: September 7, 2010Assignee: Meiji Seika Kaisha, Ltd.Inventors: Manabu Watanabe, Naoki Mido, Takayoshi Tamura, Naomi Sumida, Takashi Yaguchi
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Patent number: 7776579Abstract: Disclosed is an agent for digesting a protein highly resistant to denaturation and degradation, comprising as an active ingredient an enzyme exhibiting an activity of digesting a protein highly resistant to denaturation and degradation and having the following properties: (a) activity and substrate specificity: hydrolyzing a peptide bond of a protein highly resistant to denaturation and degradation; (b) molecular weight: 31,000 (determined by SDS-polyacrylamide gel electrophoresis using a homogeneous gel having a gel concentration of 12%); (c) isoelectric point: pI 9.3 (determined by polyacrylamide gel isoelectric focusing electrophoresis); (d) optimum pH: pH 9.0 to 10.0; and (e) optimum temperature for activity: 60 to 70° C.Type: GrantFiled: October 24, 2003Date of Patent: August 17, 2010Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takehiro Miwa, Koji Nishizawa, Yoshie Hayashi, Manabu Watanabe, Yuichi Murayama, Miyako Yoshioka, Katsuhiro Miura
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Patent number: 7772426Abstract: Disclosed is a method for efficiently and highly selectively producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid, which is useful as a herbicide, through a catalytic asymmetric synthesis reaction. Specifically disclosed is a method for producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid which is characterized in that a dehydroamino acid is subjected to an asymmetric hydrogenation by using a rhodium catalyst represented by the formula (2) below and having an optically active cyclic phosphine ligand, and then the resulting product is subjected to hydrolysis: [Rh(R4)(L)]X??(2) [where R4 represents 1,5-cyclooctadien or norbornadien; L represents a substance represented by the following formula (6): (wherein R5 and R8 respectively represent a C1-4 alkyl group; R6 and R7 respectively represent hydrogen atom or hydroxyl group; and Y represents a group selected from groups represented by the following formula (7): (where Me represents methyl group)).].Type: GrantFiled: March 28, 2006Date of Patent: August 10, 2010Assignee: Meiji Seika Kaisha, Ltd.Inventors: Nobuto Minowa, Nozomu Nakanishi, Masaaki Mitomi