Patents Assigned to MELINTA THERAPEUTICS, INC.
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Publication number: 20210052608Abstract: Disclosed herein are methods of treating carbapenem-resistant bacterial infections in a subject using various dosages of minocycline.Type: ApplicationFiled: April 26, 2019Publication date: February 25, 2021Applicant: Melinta Therapeutics, Inc.Inventors: Karen FUSARO, David C. GRIFFITH, Jeffrey S. LOUTIT
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Patent number: 10864249Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.Type: GrantFiled: June 11, 2019Date of Patent: December 15, 2020Assignees: MELINTA THERAPEUTICS, INC., ABBVIE INC.Inventors: Adel Rafai Far, Gopal Krishna, Min Ding, Sanjay R. Chemburkar, Carl M. Knable, James P. Petzel, Julie J. Pruyne, Douglas M. Reamer
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Publication number: 20190290723Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.Type: ApplicationFiled: June 11, 2019Publication date: September 26, 2019Applicants: Melinta Therapeutics Inc., AbbVie Inc.Inventors: Adel RAFAI FAR, Gopal KRISHNA, Min DING, Sanjay R. CHEMBURKAR, Carl M. KNABLE, James P. PETZEL, Julie J. PRUYNE, Douglas M. REAMER
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Patent number: 10328118Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.Type: GrantFiled: February 22, 2017Date of Patent: June 25, 2019Assignees: MELINTA THERAPEUTICS, INC., ABBVIE INC.Inventors: Adel Rafai Far, Gopal Krishna, Min Ding, Sanjay R. Chemburkar, Carl M. Knable, James P. Petzel, Julie J. Pruyne, Douglas M. Reamer
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Patent number: 10259825Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.Type: GrantFiled: January 5, 2017Date of Patent: April 16, 2019Assignee: Melinta Therapeutics, Inc.Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Shili Chen, Marco Devivo, Rongliang Lou, Brian T. Wimberly
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Patent number: 10201587Abstract: The present invention is directed to methods of inhibition, delay of formation, treatment, prophylaxis and/or prevention of infections caused by bacteria that exhibit tolerance to antimicrobial agents, including slow growing, stationary-phase and biofilm forming bacteria, through the use of glycopeptide antibiotics, such as oritavancin.Type: GrantFiled: April 2, 2009Date of Patent: February 12, 2019Assignee: MELINTA THERAPEUTICS, INC.Inventors: Eve Neesham-Grenon, Gregory Moeck, Adam Belley, Thomas R. Parr, Jr., Adel Rafai Far
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Patent number: 10106543Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.Type: GrantFiled: September 9, 2014Date of Patent: October 23, 2018Assignee: Melinta Therapeutics, Inc.Inventors: Zoltan F. Kanyo, Ashoke Bhattacharjee, Erin M. Duffy, Andrea Marra
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Patent number: 9937183Abstract: Methods and compounds for treating, preventing, reducing the risk of and/or delaying the onset of a microbial infection in a subject are disclosed herein, wherein the microbial infection is caused by one or more microorganisms (e.g., one or more bacteria) which can be used as a biological weapon, such as Bacillus anthracis, Franciscella tularensis, Yersinia pestis, Burkholderia mallei, and Burkholderia pseudomallei. Also disclosed are pharmaceutical compositions or kits for treating, preventing, reducing the risk of and/or delaying the onset of a microbial infection.Type: GrantFiled: September 9, 2014Date of Patent: April 10, 2018Assignee: Melinta Therapeutics, Inc.Inventors: Zoltan F. Kanyo, Ashoke Bhattacharjee
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Patent number: 9845297Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.Type: GrantFiled: October 16, 2015Date of Patent: December 19, 2017Assignee: Melinta Therapeutics, Inc.Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
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Patent number: 9573962Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.Type: GrantFiled: April 8, 2015Date of Patent: February 21, 2017Assignee: Melinta Therapeutics, Inc.Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Shili Chen, Marco DeVivo, Rongliang Lou, Brian T. Wimberly
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Patent number: 9550783Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.Type: GrantFiled: May 19, 2014Date of Patent: January 24, 2017Assignee: MELINTA THERAPEUTICS, INC.Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
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Patent number: 9409896Abstract: The present invention relates to carrier systems useful for pharmaceutical compositions. These carriers comprise an emulsifier, and also in further embodiments a polymeric dissolution aid. These carriers are useful for delivering pharmaceutical actives such as antimicrobial agents.Type: GrantFiled: November 1, 2011Date of Patent: August 9, 2016Assignee: Melinta Therapeutics, Inc.Inventors: Eric S. Burak, Danping Li, David S. Dresback
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Patent number: 9376400Abstract: The present invention relates to processes for the preparation of triazoles. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.Type: GrantFiled: July 7, 2014Date of Patent: June 28, 2016Assignee: MELINTA THERAPEUTICS, INC.Inventors: Shili Chen, Rongliang Lou, Yusheng Wu, Jiacheng Zhou, Roger Hanselmann
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Patent number: 9221827Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.Type: GrantFiled: April 11, 2012Date of Patent: December 29, 2015Assignee: Melinta Therapeutics, Inc.Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Shili Chen, Zoltan F. Kanyo, Matthew H. Scheideman, Yuanqing Tang
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Patent number: 9216979Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.Type: GrantFiled: October 15, 2010Date of Patent: December 22, 2015Assignee: Melinta Therapeutics, Inc.Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
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Patent number: 9193731Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.Type: GrantFiled: October 15, 2010Date of Patent: November 24, 2015Assignee: Melinta Therapeutics, Inc.Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Zoltan F. Kanyo, Jacek G. Martinow, Ik-Hyeon Paik, Matthew H. Scheideman, Sandra Sinishtaj, Brian T. Wimberly, Yusheng Wu
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Publication number: 20150258092Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: ApplicationFiled: November 25, 2014Publication date: September 17, 2015Applicants: YALE UNIVERSITY, MELINTA THERAPEUTICS, INC.Inventors: Thomas Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
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Patent number: 9085600Abstract: The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. These compounds are represented by the following formula (I): wherein R1, R2, etc. are defined as in claim 1.Type: GrantFiled: June 14, 2013Date of Patent: July 21, 2015Assignee: Melinta Therapeutics, Inc.Inventors: Ashoke Bhattacharjee, Zoltan F. Kanyo
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Patent number: 9023843Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.Type: GrantFiled: October 15, 2010Date of Patent: May 5, 2015Assignee: Melinta Therapeutics, Inc.Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Shili Chen, Marco DeVivo, Rongliang Lou, Brian T. Wimberly
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Patent number: RE46617Abstract: The present invention relates to the field of synthesizing anti-infective compounds. More particularly, the invention relates to synthesizing a family of quinolone compounds useful as anti-infective agents. The invention includes a process for preparing a quinolone compound wherein less than about 0.40% of dimeric impurity of the quinolone is produced.Type: GrantFiled: June 18, 2015Date of Patent: November 28, 2017Assignee: MELINTA THERAPEUTICS, INC.Inventors: Roger Hanselmann, Maxwell M. Reeve, Graham Johnson