Patents Assigned to Memorial Sloan-Kettering Institute for Cancer Research
  • Triterpene saponins, methods of synthesis and uses thereof
    Patent number: 9718850
    Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: August 1, 2017
    Assignee: MEMORIAL SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
    Inventors: David Gin, Michelle Adams, Kai Deng, Philip Livingston, Govindaswami Ragupathi, Eric Chea, Alberto Fernandez-Tejada, Lars Ulrik Nordstroem, William Walkowicz, Jeffrey Gardner, Derek Tan
  • Synthesis of glycoconjugates of the lewis y epitope and uses thereof
    Patent number: 6303120
    Abstract: The present invention provides a method of synthesizing an allyl pentasaccharide having the structure: as well as related oligosaccharide ceramides and other glycoconjugates useful as vaccines for inducing antibodies to epithelial cancer cells in an adjuvant therapy therefor, and in a method for preventing recurrence of epithelial cancer.
    Type: Grant
    Filed: July 24, 1995
    Date of Patent: October 16, 2001
    Assignee: Memorial Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Victor Behar, Kenneth O. Lloyd