Patents Assigned to Merck
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Patent number: 11997922Abstract: The present invention relates to certain fluorenes, to the use of the compounds in an electronic device, and to an electronic device comprising at least one of these compounds. The present invention furthermore relates to a process for the preparation of the compounds and to a formulation and composition comprising one or more of the compounds.Type: GrantFiled: February 20, 2023Date of Patent: May 28, 2024Assignee: Merck Patent GmbHInventors: Teresa Mujica-Fernaud, Elvira Montenegro, Amir Hossain Parham, Arne Buesing, Frank Voges
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Patent number: 11994803Abstract: The present invention relates to a composition including a sulfonic acid selected from the group consisting of an alkylbenzenesulfonic acid, or its hydrate, a sulfosalicyclic, or its hydrate, and mixtures thereof and the solvent dipropylene glycol dimethyl ether [CAS registry number 111109-77-4] (III).Type: GrantFiled: July 9, 2020Date of Patent: May 28, 2024Assignee: Merck Patent GmbHInventors: Hengpeng Wu, Robert Arent
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Patent number: 11993602Abstract: The present invention provides a compound of Formula (I) Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.Type: GrantFiled: August 5, 2019Date of Patent: May 28, 2024Assignee: Merck Sharp & Dohme LLCInventors: David Witter, Shuhei Kawamura, Michelle Machacek, Ryan Quiroz, Michael H. Reutershan, Sebastian Schneider, Phieng Siliphaivanh, Yingchun Ye, Charles S. Yeung
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Patent number: 11993572Abstract: The present invention relates to a composition which comprises an electron-transporting host and a hole-transporting host, to the use thereof in electronic devices and to electronic devices containing this composition. The electron-transporting host is particularly preferably selected from the class of the lactams. The hole-transporting host is preferably selected from the class of the biscarbazoles.Type: GrantFiled: July 2, 2018Date of Patent: May 28, 2024Assignee: Merck Patent GmbHInventors: Amir Parham, Jonas Kroeber, Tobias Grossmann, Anja Jatsch, Christian Eickhoff, Christian Ehrenreich
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Patent number: 11992521Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.Type: GrantFiled: October 25, 2022Date of Patent: May 28, 2024Assignee: Merck Sharp & Dohme LLCInventors: Patrick Leonard Ahl, Akhilesh Bhambhani, Christopher Jon Farrell, Patrick McHugh, Morrisa C. Jones, Daniel D. Roth, Jessica R. Sinacola, Justin Stanbro, Matthew P. Watson, Emily Wen, Michael A. Winters
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Patent number: 11992491Abstract: The present invention refers to a crystalline salt comprising 5-methyl-(6S)-tetrahydrofolic acid and L-valine ethyl ester wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid and L-valine ethyl ester is from 1:0.3 to 1:3.0 (in mol/mol) and/or hydrates and/or solvates thereof as well as to a process of obtaining the same.Type: GrantFiled: July 2, 2019Date of Patent: May 28, 2024Assignee: MERCK PATENT GMBHInventors: Rudolf Moser, Viola Groehn, Ruth Boehni Stamm, Fritz Blatter, Martin Szelagiewicz
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Patent number: 11995593Abstract: An adaptive risk management application retrieves data corresponding to an asset. The asset is a computing device or software application of an enterprise system. The adaptive risk management application identifies a set of vulnerabilities of the asset. The adaptive risk management application determines, for each identified vulnerability, a likelihood of a threat actor successfully exploiting the vulnerability. The adaptive risk management application determines, based on the likelihoods, a risk score for the asset. The adaptive risk management application sends the risk score for display.Type: GrantFiled: November 19, 2019Date of Patent: May 28, 2024Assignee: Merck Sharp & Dohme LLCInventors: Mark Joseph Risoldi, Sethuraman Balasubramanian
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Patent number: 11992489Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.Type: GrantFiled: August 12, 2019Date of Patent: May 28, 2024Assignee: Merck Sharp & Dohme LLCInventors: Dane Clausen, Xavier Fradera, Yongxin Han, Alexander Pasternak, Li Xiao, Hongjun Zhang
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Patent number: 11991924Abstract: The present invention describes carbazole, dibenzofuran, dibenzothiophene and fluorene derivatives which are substituted by electron-deficient heteroaryl groups, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention furthermore relates to a process for the preparation of the compounds according to the invention and to electronic devices comprising these compounds.Type: GrantFiled: November 25, 2022Date of Patent: May 21, 2024Assignee: Merck Patent GmbHInventors: Amir Hossain Parham, Anja Jatsch, Thomas Eberle, Tobias Grossmann, Jonas Valentin Kroeber, Lars Dobelmann-Mara
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Publication number: 20240158754Abstract: The present invention provides a method of reducing a high mannose glycan (HMG) content of a protein (e.g., monoclonal antibody) expressed during a mammalian cell culture (e.g., CHO cell culture) process, as well as a cell culture medium for reducing an HMG content of a protein (e.g., monoclonal antibody) expressed during a mammalian cell culture (e.g., CHO cell culture) process.Type: ApplicationFiled: March 3, 2022Publication date: May 16, 2024Applicant: MERCK SHARP & DOHME LLCInventors: Gaurav Chauhan, Wai Lam Wong Ling
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Publication number: 20240158388Abstract: The present invention is directed to pro drugs of 2-methyl-N-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)-6-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-4-amine which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.Type: ApplicationFiled: December 13, 2023Publication date: May 16, 2024Applicant: Merck Sharp & Dohme LLCInventors: Sachin Mittal, Jason W. Skudlarek, Izzat T. Raheem
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Publication number: 20240163667Abstract: Method and System to remote control different electronic instruments (2) by using a mobile computer device (1) with a software (7) including a compatible graphical user interface (5), which comprises the following steps of Login and Authentication of a user (3) at the mobile device (1); Pairing of an electronic instrument (2) with the mobile device (1) to identify the instrument (2) by the user (3); Performing an security check by the mobile device (1) if the authenticated user (3) is authorized to control the identified instrument (2); If the user (3) is authorized pairing of the mobile device (1) with the instrument (2) via a data connection, loading of the correct compatible graphical user interface (5) of the paired instrument (2) and displaying it at the screen of the mobile device (1); and Remote controlling of the instrument (2) by using the graphical user interface (5) displayed on the mobile device (1).Type: ApplicationFiled: March 29, 2022Publication date: May 16, 2024Applicant: MERCK PATENT GMBHInventor: Luc FELDEN
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Patent number: 11980623Abstract: The present invention is directed to a pharmaceutical composition comprising the compound suvorexant, or a pharmaceutically acceptable salt thereof, a concentration-enhancing polymer, and optionally a pharmaceutically acceptable surfactant.Type: GrantFiled: September 14, 2021Date of Patent: May 14, 2024Assignee: Merck Sharp & Dohme LLCInventors: Paul A. Harmon, Narayan Variankaval, Michael Lowinger, Chad David Brown, Francis Flanagan
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Patent number: 11985209Abstract: A method is proposed for storing at least one piece of data representative of a content available at a content server connected to a constellation of communication satellites. Such method comprises: intercepting (S200) at least one request for the content transmitted by at least one terminal equipment connected to the constellation of communication satellites; determining (S210), based on the at least one request, a context wherein the content is required by the at least one terminal; downloading (S220) the at least one piece of data from the content server at time slots function of the context; and storing (S230) in a data storage device the at downloaded least one piece of data for subsequent delivery to a given terminal.Type: GrantFiled: June 1, 2021Date of Patent: May 14, 2024Assignee: Merck Patent GmbHInventor: Dieter Schroth
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Patent number: 11981726Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.Type: GrantFiled: December 13, 2022Date of Patent: May 14, 2024Assignee: Merck Sharp & Dohme LLCInventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su
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Patent number: 11981701Abstract: The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.Type: GrantFiled: August 5, 2019Date of Patent: May 14, 2024Assignee: Merck Sharp & Dohme LLCInventors: Jongwon Lim, Michelle Machacek, Michael H. Reutershan, Sebastian Schneider
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Patent number: 11982942Abstract: The present invention relates to novel positive tone photoresist formulations comprising using crosslinkable siloxane polymers. The siloxane polymers used in the positive tone photoresist formulations are crosslinkable and comprise a first repeating unit, which contains at least one maleimide group, and a second repeating unit, which does not contain a maleimide group. The present invention further provides a manufacturing method for a microelectronic structure using a positive tone photoresist formulation according to the present invention and to an electronic device comprising a microelectronic structure, which is obtained or obtainable by said manufacturing method.Type: GrantFiled: October 9, 2020Date of Patent: May 14, 2024Assignee: MERCK PATENT GMBHInventors: Karsten Koppe, Naofumi Yoshida
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COMPOSITIONS AND METHODS FOR TREATING CANCER WITH SUBCUTANEOUS ADMINISTRATION OF ANTI-PD1 ANTIBODIES
Publication number: 20240150467Abstract: The invention relates to compositions and methods for treating cancer in a patient comprising subcutaneously administering a PD-1 antagonist, e.g., an anti-PD-1 antibody (e.g. pembrolizumab), or antigen binding fragment thereof, with or without hyaluronidase every six weeks, in specific amounts to the patient. In specific embodiments, the amount of anti-PD-1 antibody, or antigen binding fragment thereof, is about 600 mg to about 1000 mg. In specific embodiments, the administration occurs about every three weeks, and the amount of anti-PD-1 antibody, or antigen binding fragment thereof, is about 300 mg to about 500 mg. In certain embodiments, the PD-1 antagonist is pembrolizumab, or an antigen binding fragment thereof. Also provided are compositions and kits formulated for subcutaneous administration comprising a particular dosage of an anti-PD-1 antibody, or antigen-binding fragment thereof, and uses thereof for treating cancer.Type: ApplicationFiled: October 11, 2023Publication date: May 9, 2024Applicant: Merck Sharp & Dohme LLCInventors: Omobolaji O. Akala, Carolina De Miranda Silva, Elliot Keith Chartash, Mallika Lala, III, Kapil Mayawala -
Publication number: 20240150720Abstract: The present invention relates to 3D cell cultures, which contains hepatic cells and are infected by a pathogen, methods for preparing such cell cultures and uses thereof.Type: ApplicationFiled: January 16, 2024Publication date: May 9, 2024Applicant: Merck Patent GmbHInventors: Thomas SPANGENBERG, Beatrice Greco, Paula Maria Marques Leal Sanches Alves, Manuel José Teixeira Carrondo, Ana Catarina Mauricio Brito Ataíde, Sofia Raquel Paulo Rebelo, Francisca Maria De Andrade Terras Arez, Daniel Filipe Mestre Simão, Rui Miguel Prudêncio Pignatelli, Diana Marisa Pinto Freire Fontinha, Marta Monteiro Maia Machado
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Publication number: 20240150729Abstract: The instant invention discloses a closed-system, serum-free, microcarrier-based up-stream process to produce dengue virus. The process comprises a closed-system cell expansion comprising cell passages taking place in closed-system containers. These cell expansions represent a closed process, with replacement media, a cell-detachment agent, and quench medium added though sterile, weldable tubing (a closed-system environment) to eliminate all open aseptic processing following the initial vial thaw of the adherent cells. The viral production takes place in a closed-system bioreactor in adherent cell culture grown on microcarriers providing sufficient cell mass to support the production of dengue virus.Type: ApplicationFiled: March 17, 2022Publication date: May 9, 2024Applicant: Merck Sharp & Dohme LLCInventors: Pooja Chadha, Kent Harley Hamaker, Shannon Haughney, Samantha J. Marrone, Christopher Ton, Igor Zabrodin