Abstract: Compounds of the formula (I), in which R1, R2, R3, R3?, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.
Type:
Grant
Filed:
November 26, 2009
Date of Patent:
April 23, 2013
Assignee:
Merck Patent Gesellschaft mit Beschränkter Haftung
Inventors:
Dieter Dorsch, Oliver Schadt, Frank Stieber, Andree Blaukat
Abstract: The present invention relates to a novel etching media in the form of printable, homogeneous etching pastes with non-Newtonian flow properties for the improved etching of inorganic oxides and silicon surfaces and which allow to prepare smaller features.
Type:
Application
Filed:
May 17, 2011
Publication date:
April 18, 2013
Applicants:
NANO TERRA, INC., MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Inventors:
Jennifer Gillies, Ralf Kuegler, Eric Stern, Brian Mayers, Patrick Reust, Lindsay Hunting
Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
Type:
Application
Filed:
June 1, 2011
Publication date:
April 18, 2013
Applicant:
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Inventors:
Andreas Taugerbeck, Achim Goetz, Stephan Derow
Abstract: The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in archival formalin fixed paraffin embedded (FFPE) tissue. The invention also relates to methods for preparing monoclonal rabbit antibodies, wherein the immunogen is an insect expression culture-derived recombinant extracellular integrin domain, and another method for screening anti-integrin antibodies that discriminate between closest integrin homologues and that are especially suited for immunohistochemistry in FFPE material.
Type:
Grant
Filed:
July 15, 2010
Date of Patent:
April 16, 2013
Assignee:
Merck Patent Gesellschaft Mit Beschrankter Haftung
Inventors:
Simon Goodman, Claudia Wilm, Francesc Mitjans
Abstract: The present invention relates to an optical switch element, comprising a liquid-crystalline medium for the temperature-dependent regulation of radiant energy flow. The invention furthermore relates to the use of the optical switch element for the regulation of radiant energy flow between interior spaces and the environment and for the regulation of the temperature of interior spaces. The invention furthermore relates to a liquid-crystalline medium, characterised in that it comprises 5-95% of a compound of the formula (I), in particular for use in the optical switch elements according to the invention.
Type:
Application
Filed:
May 4, 2011
Publication date:
April 11, 2013
Applicant:
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Abstract: The invention relates to compounds of the general formula (I) wherein R1, R2, R3, R4, R5, R6, i and j have the meanings given in claim 1, and to the use thereof as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy.
Type:
Application
Filed:
November 28, 2012
Publication date:
April 11, 2013
Applicant:
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Inventor:
Merck Patent Gesellschaft mit Beschrankter Haftu
Abstract: The present invention relates to quinoxalinone derivatives of formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined herein, as insulin secretion stimulators. Specific such quinoxaline compounds are also an aspect of the invention. The invention also relates to the preparation and use of these quinoxalinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
Type:
Grant
Filed:
January 15, 2009
Date of Patent:
April 9, 2013
Assignee:
Merck Patent Gesellschaft mit Beschränkter Haftung
Abstract: The invention relates to a method of aligning reactive mesogens (RM) on a substrate subjected to particle beam treatment, to RM's oriented by said method, especially in form of thin layers, to oriented polymers and polymer films obtained from such oriented RM's and RM layers, and to the use of the RM's, layers, polymers and films in optical, electronic and electrooptical applications.
Type:
Grant
Filed:
August 10, 2007
Date of Patent:
April 9, 2013
Assignee:
Merck Patent Gesellschaft mit Beschränkter Haftung
Inventors:
Owain Llyr Parri, Alison Linda May, Julian Vaughan-Spickers, Karl Skjonnemand, Oleg Yaroshchuck
Abstract: The present invention relates to a switch element, which is thermo-responsive and which switches between a less transmissive state for radiant energy and a more transmissive state for radiant energy, and which comprises a liquid-crystalline medium. The invention furthermore relates to the use of the switch element for the regulation of radiant energy flow between interior spaces and the environment and for the regulation of the temperature of interior spaces. The invention furthermore relates to a liquid-crystalline medium, characterised in that it comprises 5-60% of a compound of the formula (I), in particular for use in the switch elements according to the invention.
Type:
Application
Filed:
May 12, 2011
Publication date:
April 4, 2013
Applicant:
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Abstract: Compounds of the formula I, in which R1, R2, R3, R3?, R4 and D have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.
Type:
Grant
Filed:
April 24, 2009
Date of Patent:
March 26, 2013
Assignee:
Merck Patent Gesellschaft Mit Beschrankter Haftung
Inventors:
Dieter Dorsch, Oliver Schadt, Frank Stieber, Andree Blaukat
Abstract: The present invention relates to novel formulations comprising an organic semiconductor (OSC) and one or more organic solvents. The formulation comprises a viscosity at 25° C. of less than 15 mPas and the boiling point of the solvent is at most 400° C. Furthermore, the present invention describes the use of these formulations as inks for the preparation of organic electronic (OE) devices, especially organic photovoltaic (OPV) cells and OLED devices, to methods for preparing OE devices using the novel formulations, and to OE devices, OLED devices and OPV cells prepared from such methods and formulations.
Type:
Application
Filed:
April 28, 2011
Publication date:
March 21, 2013
Applicant:
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Inventors:
Philip Edward May, Mark James, Piotr Wierzchowiec, Stephen Bain, Paul Craig Brookes, Edgar Kluge, Li Wei Tan, David Sparrowe, Magda Goncalves-Miskiewicz
Abstract: The invention relates to a liquid-crystalline medium having negative dielectric anisotropy which comprises at least one compound of the formula I in which R1, R1* and a have the meanings indicated in Claim 1, and to the use thereof for an active-matrix display, in particular based on the VA, PS-VA, PALC, FFS or IPS effect.
Type:
Grant
Filed:
December 17, 2009
Date of Patent:
March 19, 2013
Assignee:
Merck Patent Gesellschaft mit Beschränkter Haftung
Inventors:
Melanie Klasen-Memmer, Matthias Bremer, Konstantin Schneider, Detlef Pauluth
Abstract: The invention relates to conjugated polymers that comprise phenanthrene and/or indenofluorene units and are free of amine-containing units, to methods of their preparation, to the use of the polymers in organic electronic (OE) devices, and to OE devices comprising the polymers.
Type:
Grant
Filed:
May 4, 2010
Date of Patent:
March 19, 2013
Assignee:
Merck Patent Gesellschaft mit beschrankter Haftung
Inventors:
David Sparrowe, Niels Schulte, Frank Egon Meyer
Abstract: The present invention refers to a method for selectively structuring of a polymer matrix comprising CNT (carbon nano tubes) on a flexible plastic substructure. The method also includes a suitable etching composition, which allows to proceed the method in a mass production.
Type:
Application
Filed:
April 26, 2011
Publication date:
March 14, 2013
Applicant:
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Inventors:
Werner Stockum, Arjan Meijer, Ingo Koehler
Abstract: The invention relates to mixtures comprising at least one phosphor of the formula I, AaLuc,CexAll,GamO12??(I) and at least one red-emitting phosphor, to a corresponding process for the preparation of these mixtures, and to the use thereof as conversion phosphors.
Type:
Application
Filed:
April 26, 2011
Publication date:
March 14, 2013
Applicant:
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Inventors:
Holger Winkler, Andreas Benker, Ralf Petry, Tim Vosgroene
Abstract: The present invention relates to thiophene derivatives, to processes and intermediates for the preparation thereof, to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, and to LC media and LC displays comprising same.
Type:
Grant
Filed:
March 30, 2009
Date of Patent:
March 12, 2013
Assignee:
Merck Patent Gesellschaft mit beschrankter Haftung
Inventors:
Axel Jansen, Detlef Pauluth, Harald Hirschmann, Markus Czanta
Abstract: The present invention relates to dielectrically positive liquid-crystalline media comprising a dielectrically neutral or slightly positive component, component A, comprising one or more dielectrically neutral or slightly positive compounds of the formula I in which the parameters have the meaning indicated in the specification, and a dielectrically positive component, component B, comprising one or more dielectrically positive compounds, and optionally a second dielectrically neutral component, component C, and to liquid-crystal displays containing these media, especially active-matrix displays and in particular TN, IPS and FFS displays.
Type:
Grant
Filed:
January 15, 2009
Date of Patent:
March 12, 2013
Assignee:
Merck Patent Gesellschaft mit beschränkter Haftung
Inventors:
Michael Wittek, Brigitte Schuler, Volker Reiffenrath
Abstract: The instant invention relates to dielectrically positive nematic media comprising one or more compounds of formula I and one or more compounds of formulae II and III and optionally one or more compounds of formulae IV and V and liquid crystal devices comprising these media and especially to fast switching electro-optical devices.
Type:
Grant
Filed:
March 25, 2011
Date of Patent:
March 12, 2013
Assignee:
Merck Patent Gesellschaft mit beschrankter Haftung