Patents Assigned to Merck Sharp & Dohme (I.A.) Corp.
  • Aralkylaminoethanol heterocyclic compounds
    Patent number: 4686222
    Abstract: Heterocyclic aminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: August 11, 1987
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
    Patent number: 4537902
    Abstract: Novel 4-substituted-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: August 27, 1985
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Edward J. Cragoe, Jr., Clarence S. Rooney, Haydn W. R. Williams
  • N-(Alkenyl)-2-aza-2'-hydroxy-5,6-benzotricyclo[6.3.0.sup.1,8.0.sup.4,11 ] u n
    Patent number: 4454325
    Abstract: Novel N-(substituted) derivatives of 2-aza-2'-hydroxy-5,6-benzotricyclo[6.3.0.sup.1,8.0.sup.4,11 ] undecane of the formula: ##STR1## are centrally acting analgesics effective in the relief of pain.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: June 12, 1984
    Assignee: Merck Sharp & Dohme I.A. Corp.
    Inventor: Robert N. Young
  • 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
    Patent number: 4431652
    Abstract: 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives of the formula: ##STR1## where X and Y are independently selected from the group consisting of hydrogen, halogen, and C.sub.1-6 alkyl; provided that positions 2 and 6 of the substituted phenyl moiety may not be substituted by C.sub.3-6 alkyl; or a pharmaceutically acceptable salt thereof;useful in treating urinary tract, especially renal calcium oxalate lithiasis.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: February 14, 1984
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Edward J. Cragoe, Jr., Clarence S. Rooney, Haydn W. R. Williams
  • 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
    Patent number: 4428956
    Abstract: 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives of the formula: ##STR1## where X and Y are independently selected from the group consisting of hydrogen, halogen, and C.sub.1-6 alkyl; provided that positions 2 and 6 of the substituted phenyl moiety may not be substituted; and n is 0 or 1;or a pharmaceutically acceptable salt thereof; useful in treating urinary tract, especially renal calcium oxalate lithiasis.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: January 31, 1984
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Edward J. Cragoe, Jr., Clarence S. Rooney, Haydn W. R. Williams
  • Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same
    Patent number: 4377568
    Abstract: An enteric coating medium for solid medicinal dosage units is prepared by precipitation of a pH sensitive polymer from an alcoholic solution of such a polymer and a plasticizing agent to produce a suspension of fine particles of a mixture of polymer and plasticizing agent.
    Type: Grant
    Filed: August 12, 1981
    Date of Patent: March 22, 1983
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventor: Sham K. Chopra
  • 4-(Substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
    Patent number: 4377588
    Abstract: Novel 4-(substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.
    Type: Grant
    Filed: September 11, 1979
    Date of Patent: March 22, 1983
    Assignees: Merck Sharp & Dohme (I.A.) Corp., Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Clarence S. Rooney, Haydn W. R. Williams
  • N -(Substituted)-2-aza-2'-hydroxy-5,6-benzotricyclo[6.3.0.sup.1,8.0.sup.4,1 1 ] undecane centrally-acting analgesics
    Patent number: 4376779
    Abstract: Novel N-(substituted) derivatives of 2-aza-2'-hydroxy-5,6-benzotricyclo[6.3.0.sup.1,8.0.sup.4,11 ] undecane of the formula: ##STR1## are centrally acting analgesics effective in the relief of pain.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: March 15, 1983
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Patrice C. Belanger, Robert N. Young
  • Quinolinyl ethanolamines
    Patent number: 4348398
    Abstract: Heterocyclic ethanolamines of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: September 7, 1982
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Joseph G. Atkinson, Burton K. Wasson
  • 2-(3-Substituted amino-2-hydroxypropoxy)-3-piperidino pyrazines for use in treating hypertension
    Patent number: 4343802
    Abstract: 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds optionally having substituents in the 5 and/or 6 positions, possessing .beta.-adrenergic blocking properties are described. The products are prepared by reaction of a 2-chloro (or hydroxy) pyrazine with a 5-hydroxymethyl (or sulfonyloxymethyl) oxazolidine followed by acid hydrolysis.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: August 10, 1982
    Assignee: Merck, Sharp & Dohme (I.A.) Corp.
    Inventors: Burton K. Wasson, Leonard M. Weinstock
  • (3-Aralkylamino-2-or-propoxy) heterocyclic compounds
    Patent number: 4331679
    Abstract: Compounds of the formula Het-O-CH.sub.2 -CHOR-CH.sub.2 -NH-aralkyl where Het is ##STR1## are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: May 25, 1982
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventor: Yves Girard
  • 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists
    Patent number: 4237160
    Abstract: Novel 3-hydroxymethyldibenzo[b,f]thiepin and derivatives are prepared and employed in the treatment and control of allergic conditions such as allergic asthma.
    Type: Grant
    Filed: November 27, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Pierre A. Hamel, Joshua Rokach
  • 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds and compositions
    Patent number: 4193995
    Abstract: 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds optionally having substituents in the 5 and/or 6 positions, possessing .beta.-adrenergic blocking properties are described. The products are prepared by reaction of a 2-chloro(or hydroxy)pyrazine with a 5-hydroxymethyl(or sulfonyloxymethyl)oxazolidine followed by acid hydrolysis.
    Type: Grant
    Filed: March 8, 1977
    Date of Patent: March 18, 1980
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Burton K. Wasson, Leonard M. Weinstock
  • 2-(4-Substituted-1,2,5-thiadiazole-3-yloxy)-acetaldehydes
    Patent number: 4145550
    Abstract: Novel 2-(4-substituted-1,2,5-thiadiazol-3-yloxy) acetaldehydes are disclosed. These acetaldehydes are useful as intermediates for preparing certain .beta.-adrenergic blocking agents.
    Type: Grant
    Filed: September 21, 1977
    Date of Patent: March 20, 1979
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventor: Patrice C. Belanger