Patents Assigned to Mercky Sharp & Dohme Corp.
  • Compounds for inhibiting KSP kinesin activity
    Patent number: 8796460
    Abstract: The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: August 5, 2014
    Assignee: Mercky Sharp & Dohme Corp.
    Inventors: M. Arshad Siddiqui, Chaoyang Dai, Umar Faruk Mansoor, Liping Yang, Lalalnthi Dilrukshi Vitharana, Angie R. Angeles