Patents Assigned to Merial
  • ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS
    Publication number: 20170233438
    Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.
    Type: Application
    Filed: December 14, 2016
    Publication date: August 17, 2017
    Applicant: MERIAL INC.
    Inventors: Loic Le Hir de Fallois, Greg Pacofsky, Alan Long, Charles Q. Meng, Hyoung Ik Lee
  • Vaccine formulations comprising saponin-containing adjuvants
    Patent number: 9730987
    Abstract: The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: August 15, 2017
    Assignee: MERIAL INC.
    Inventors: Noel Joseph Francois Detraz, Guillaume Rigaut
  • Antioxidants Against Oxidative Stress During a Stressor Event
    Publication number: 20170224756
    Abstract: The present invention encompasses an effervescent Grape extract plus selenium composition which improves stress response. The invention also encompasses methods of improving stress response, such as stress response to vaccination or weaning, by administration of the composition. The invention also encompasses methods of producing meat with improved quality by raising an animal on a diet supplemented with an effervescent Grape extract plus selenium composition.
    Type: Application
    Filed: February 2, 2017
    Publication date: August 10, 2017
    Applicant: MERIAL INC.
    Inventors: Alphons Rutten, Caroline Pommellet, Pierre Chicoteau
  • NEWCASTLE DISEASE VIRUS VECTORED AVIAN VACCINES
    Publication number: 20170224807
    Abstract: The present invention encompasses engineered Newcastle Disease Virus (NDV) vaccines or compositions. The vaccine or composition may be a recombinant vaccine. The invention also encompasses recombinant vectors encoding and expressing avian pathogen antigens, more specifically avian influenza proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals, in particular avian, against disease.
    Type: Application
    Filed: February 16, 2017
    Publication date: August 10, 2017
    Applicant: Merial Inc.
    Inventors: Michel Bublot, Frederic REYNARD, François-Xavier LE GROS
  • RECOMBINANT ADENOVIRUS VECTORED FMDV VACCINES AND USES THEREOF
    Publication number: 20170216422
    Abstract: The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
    Type: Application
    Filed: January 30, 2017
    Publication date: August 3, 2017
    Applicants: MERIAL INC., Genvec Inc., THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary of Homeland Security
    Inventors: Justin Widener, Leszlie Woodyward, Leonardo Siger, Douglas Brough, Damodar Ettyreddy, Jason Gall, Duncan McVey, Tom Burrage
  • Recombinant spike protein subunit based vaccine for porcine epidemic diarrhea virus (PEDV)
    Patent number: 9713639
    Abstract: The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing PEDV antigens. The invention also encompasses recombinant vectors encoding and expressing PEDV antigens, epitopes or immunogens which can be used to protect porcine animals against PEDV.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: July 25, 2017
    Assignee: MERIAL, INC.
    Inventors: Paulraj Lawrence, Russell Bey
  • Multi-chamber, multi-formulation fluid delivery system
    Patent number: 9706754
    Abstract: The application discloses a multi-chamber, multi-formulation fluid delivery system, comprising a multi-chamber applicator in fluid communication with multi-chamber packaging. Applicators according to the instant disclosure have reduced squeeze-strength requirements, and are useful for dispensing fluids, including medicaments, to animals, including livestock animals. The multi-chamber packaging provides separate storage for formulations containing incompatible active ingredients, and is suitable for use with the multi-chamber applicator. The application also discloses methods for using the system to simultaneously deliver multiple active ingredients, at least some of which are not suitable for co-formulation, thus reducing the time, economic burden and animal stress involved with applying multiple, separate formulations to animals.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: July 18, 2017
    Assignee: MERIAL, INC.
    Inventors: Todd Luepke Prescott, Rodney Gordon Walker, Gareth Nigel Lauchlan, David Andrew Trow
  • Recombinant AAV Vectors Expressing Osteoprotective genes, including HAS2 and Lubricin, useful in the Treatment of Osteoarthritis and Related Joint Conditions in Mammals
    Publication number: 20170198263
    Abstract: The present disclosure relates to recombinant viral vectors, to pharmaceutical compositions comprising such recombinant vectors, and to methods for prevention and treatment of osteoarthritis in mammals. In particular, this disclosure provides adeno-associated virus (AAV) vectors capable of expressing, in a host, osteoprotective/chondroprotective bioactive proteins, including hyaluronan synthase 2 (HAS2) and lubricin (PRG4). Methods of production of these AAV are provided, as are methods of treatment of osteoarthritis in mammalian joints, by the long-term gene expression of osteoprotective/chondroprotective proteins, including HAS2 and PRG4, in both synovial and chondrocyte cells.
    Type: Application
    Filed: January 13, 2017
    Publication date: July 13, 2017
    Applicants: MERIAL INC., GENZYME CORPORATION
    Inventors: Monica Dias Figueiredo, Sirkka RM Kyostio-Moore, Patricia Berthelette
  • Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof
    Patent number: 9695129
    Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: July 4, 2017
    Assignee: MERIAL INC.
    Inventor: Charles Q Meng
  • Methods of Providing Grass Growth and Nematode Suitability Indices to Assist Determination of Timing of Parasiticide Treatment
    Publication number: 20170181403
    Abstract: The present invention builds and conveys to users in need thereof a Grass Growth Index (GGI) and a Nematode Suitability Index (NSI), to assist the determination of whether and when to administer parasiticides to grazing livestock, such as bovine, ovine and caprine animals. In particular, the invention relates to a computer-implemented method whereby GGI and NSI are calculated based upon both user-supplied information (e.g. grass/forage type and location data) and user-independent information (e.g. weather and environmental condition data associated with the location over time, and grass and nematode growth parameters). Importantly, the disclosed methods provide users with information as to when and where their herds of grazing animals may be at the greatest risk of parasite infestation.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 29, 2017
    Applicant: MERIAL, INC.
    Inventor: Stephen Mario Imperiale-Hagerman
  • M Hyo Multivalent Vaccine and Uses Thereof
    Publication number: 20170182141
    Abstract: The present invention relates to compositions or vaccines for combating Mycoplasma hyopneumoniae (M hyo), Porcine Circovirus type 2 (PCV2), and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infections in animals and for increasing the ability of pigs to gain weight and/or improve death loss, methods of vaccination against the infections, and kits for use with such methods and compositions.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 29, 2017
    Applicant: MERIAL, INC.
    Inventors: Keith Wilson, Paulraj Lawrence
  • Selective embryonic structure targeting and substance delivery device
    Patent number: 9686969
    Abstract: The present disclosure relates to a device for delivering substances to specific embryonic structures, including heart and blood vessels, within a developing avian egg. The disclosure also relates to methods of using the device to produce enhanced avian embryos. Methods include administering to chicken embryos various substances, including vaccines, nutrients, and stem cells. Chickens resulting from enhanced avian embryos have advantages, including greater growth potential and resistance to pathogen infection/infestation.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: June 27, 2017
    Assignees: MERIAL INC., Agri Advanced Technologies GmbH
    Inventors: Sven Meissner, Stefan Geissler, Toni Frohnert, Doreen Goehler, Bjoern Fischer
  • Attenuated Parvovirus Vaccine for Muscovy Duck Parvovirus and Goose Parvovirus (Derzsys Disease)
    Publication number: 20170173146
    Abstract: This disclosure provides an attenuated palmiped parvovirus that affords heterologous protection for both Muscovy duck parvovirus and goose parvovirus (i.e., Derzsy's Disease). The disclosure further provides compositions comprising the same, and methods of production and use thereof.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 22, 2017
    Applicant: Merial, Inc.
    Inventor: Francois Xavier LE GROS
  • Recombinant feline leukemia virus vaccine containing optimized feline leukemia virus envelope gene
    Patent number: 9682138
    Abstract: The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: June 20, 2017
    Assignee: MERIAL, INC.
    Inventors: Herve Poulet, Thierry Heidmann
  • VETERINARY SYRINGE FOR MULTIPLE INJECTIONS
    Publication number: 20170165424
    Abstract: A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 15, 2017
    Applicant: MERIAL INC.
    Inventors: Robert William Lachlan Holmes, Rodney Gordon Walker, Todd Donald Ebbett, Colin Anthony Standing, Peter Robert Williams, Giovanni Ciampa, Michael Rossignuolo, Robert John Smith
  • Attenuated mannheimia haemolytica vaccines and methods of making and use
    Patent number: 9675682
    Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: June 13, 2017
    Assignee: MERIAL, INC.
    Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
  • Immunological Compositions Containing Attenuated Histophilus somni
    Publication number: 20170157232
    Abstract: This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.
    Type: Application
    Filed: January 30, 2017
    Publication date: June 8, 2017
    Applicant: MERIAL, INC.
    Inventors: Tammy (Kolander) Bremer, Paulraj Lawrence, Russell Bey
  • Needle-free administration of PRRSV vaccines
    Patent number: 9669085
    Abstract: The invention provides novel methods and compositions for the vaccination of porcine animals against porcine reproductive and respiratory syndrome virus (PRRSV). Described herein are immunological and/or vaccine compositions comprising a DNA vector encoding a PRRSV protein, particularly a truncated ORF7 protein, which are administered to porcines using needle-free delivery. The plasmid can include more than one nucleic acid molecule such that the plasmid can express more than one antigen. Also disclosed are methods for using and kits employing such compositions.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: June 6, 2017
    Assignees: MERIAL INC., Chulalongkorn University
    Inventors: Sanipa Suradhat, Jean-Christophe Audonnet, Catherine Charreyre
  • FMDV and E2 Fusion Proteins and Uses Thereof
    Publication number: 20170143819
    Abstract: The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV. The invention further encompasses methods of making or producing antigenic polypeptides or antigens.
    Type: Application
    Filed: November 16, 2016
    Publication date: May 25, 2017
    Applicant: MERIAL INC.
    Inventors: Jean-Christophe Audonnet, Frédéric Reynard, Natalia Bomchil, Cécile Sigoillot-Claude
  • Animal chew
    Patent number: D789650
    Type: Grant
    Filed: April 30, 2016
    Date of Patent: June 20, 2017
    Assignee: Merial Inc.
    Inventor: Eric Anthony Hansen