Patents Assigned to Metkinen Chemistry Oy
  • Carbamoylation of amines, thiophenols, mercaptanes and phenols employing organic azides
    Patent number: 8779194
    Abstract: The present invention relates to carbamoylation of amines, mercaptanes, thiophenols and phenols employing organic azides. More specifically, the invention relates to a method for generating urea derivatives, thiocarbamate derivatives and carbamate derivatives, and is based on the intermediate formation of isocyanate, starting from an organic azide. The reaction as described is useful in applications for modified nucleoside synthesis, oligonucleotide synthesis, as well as modification, labeling and conjugation of polymers and biomolecules.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: July 15, 2014
    Assignee: Metkinen Chemistry Oy
    Inventors: Andrey Yagodkin, Alex Azhayev