Patents Assigned to Metris Therapeutics Limited
  • Drug delivery device
    Patent number: 6758840
    Abstract: The invention relates to drug delivery devices for insertion into the vagina, rectum or nasal cavity comprising a body, a layer of fluid-impermeable material on at least part of said body and one or more pharmaceutical agents disposed on the surface of the material remote from said body, wherein said body comprises absorbent material. The devices exploit the highly vascularised nature of the vaginal, nasal and rectal mucosal tissue to deliver pharmaceutical agents to localised areas and/or into underlying tissues.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: July 6, 2004
    Assignee: Metris Therapeutics Limited
    Inventor: Peter Knox
  • Anti-VEGF agents in the treatment of endometriosis
    Patent number: 6121230
    Abstract: Disclosed are: a composition for use in the treatment of endometriosis, comprising an agent capable of interfering with the production and/or activity of VEGF, and a physiologically acceptable carrier substance; a composition for the treatment of endometriosis comprising an agent which inhibits the activation and/or recruitment of peritoneal macrophages, and a physiologically acceptable carrier; and method of making the compositions and their use in the treatment of endometriosis.
    Type: Grant
    Filed: January 9, 1997
    Date of Patent: September 19, 2000
    Assignee: Metris Therapeutics Limited
    Inventors: David Stephen Charnock-Jones, John McLaren, Andrew Prentice, Stephen Kevin Smith
  • FLT-4(FMS-like tyrosine kinase), FLT-15, variants thereof used as growth factor inhibitors
    Patent number: 6011003
    Abstract: Disclosed is an altered, soluble form of the FLT polypeptide being capable of binding to VEGF and thereby exerting an inhibitory effect thereon, the polypeptide comprising five or fewer complete immunoglobulin-like domains, together with pharmaceutical compositions comprising the polypeptide, and various uses thereof.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: January 4, 2000
    Assignee: Metris Therapeutics Limited
    Inventors: David Stephen Charnock-Jones, Christine Ann Boocock, Andrew Mark Sharkey, Stephen Kevin Smith