Patents Assigned to Middle Tennessee State University
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Patent number: 11980648Abstract: This disclosure describes a composition including the ginsenoside 20(S)-Rg3 (also referred to herein as Rg3) and methods of using such a composition. In some embodiments, the composition may be used to treat or prevent an alpha herpesvirus including, for example, herpes simplex virus (HSV)-1 and HSV-2. In some embodiments, the composition is substantially free of other ginsenosides.Type: GrantFiled: June 4, 2021Date of Patent: May 14, 2024Assignee: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Stephen Wright, Shannon Smith, Karen Maynard, Elliot Altman
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Patent number: 11369586Abstract: Described herein are antifungal peptoids, the development and characterization of the antifungal peptoids, methods of making the antifungal peptoids, and methods of using the antifungal peptoids. In some embodiments, the antifungal peptoids may be administered to a subject infected with or at risk of being infected with pathogenic fungi including, for example Cryptococcus spp. In some embodiments, the Cryptococcus spp. may include C. neoformans or C. gattii or both.Type: GrantFiled: December 18, 2019Date of Patent: June 28, 2022Assignee: Middle Tennessee State UniversityInventors: Kevin L. Bicker, Madyson P. Middleton, Scott A. Armstrong
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Patent number: 11286245Abstract: Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.Type: GrantFiled: September 3, 2020Date of Patent: March 29, 2022Assignee: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Jeannie Stubblefield, Zachary E. Taylor, Scott Handy, Anthony Newsome
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Patent number: 11007169Abstract: The cis-isomer and trans-isomers of the plant-derived compound gnetin H are shown have anticancer properties, anti-inflammatory properties, and low toxicity. Therapeutic and prophylactic compositions that contain cis-gnetin H, trans-gnetin H, and derivatives thereof, as well as methods of making and using said compositions, are provided. cis-gnetin H and/or trans-gnetin H can be used in purified form or as a plant extract.Type: GrantFiled: February 1, 2019Date of Patent: May 18, 2021Assignee: Middle Tennessee State UniversityInventors: Ying Gao, Elliot Altman, Anthony Farone, Hyo Park
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Patent number: 10993920Abstract: 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), as well as variants, derivatives, analogs, modifications, and conjugates thereof, are identified as therapeutic agents for treating or preventing human cancers and precancerous conditions. DMDD can be isolated from the root of Averrhoa carambola L., commonly known as starfruit. Pharmaceutical and nutraceutical compositions, as well as dietary supplements, are provided, as are methods of administration and treatment.Type: GrantFiled: December 9, 2015Date of Patent: May 4, 2021Assignee: Middle Tennessee State UniversityInventors: Ying Gao, Elliot Altman
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Publication number: 20210115491Abstract: A solid supported branched linker assay system, including an alpha compound and a beta compounds reversibly tethered to a solid support; a branched linker coupled to the solid support that tethers the alpha and beta compounds to the solid support; the branched linker having two cleavable linkers that are chemically distinct from one another, wherein a first chemically distinct linker tethers the ? compound to the branched linker and a second chemically distinct linker tethers the ? compound to the branched linker; and at least two means for cleaving the chemically distinct linkers, wherein a first cleavage means is configured to selectively cleave a first chemically distinct linker and a second cleavage means is configured to selectively cleave a second chemically distinct linker.Type: ApplicationFiled: October 29, 2020Publication date: April 22, 2021Applicant: Middle Tennessee State UniversityInventors: Kevin L. Bicker, Kevin J. Fisher, Ashley E. Corson
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Publication number: 20210053933Abstract: Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.Type: ApplicationFiled: September 3, 2020Publication date: February 25, 2021Applicant: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Jeannie Stubblefield, Zachary E. Taylor, Scott Handy, Anthony Newsome
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Patent number: 10899727Abstract: Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.Type: GrantFiled: April 11, 2017Date of Patent: January 26, 2021Assignee: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Zachary E. Taylor, Scott Handy, Anthony Farone, Hyo Park
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Publication number: 20200399238Abstract: Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.Type: ApplicationFiled: September 3, 2020Publication date: December 24, 2020Applicant: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Jeannie Stubblefield, Zachary E. Taylor, Scott Handy, Mary Farone, Erin McClelland, Caleb Sutton, Anthony Farone, Hyo Park, Danielle Araujo, Anthony Newsome
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Publication number: 20190290611Abstract: The cis-isomer and trans-isomers of the plant-derived compound gnetin H are shown have anticancer properties, anti-inflammatory properties, and low toxicity. Therapeutic and prophylactic compositions that contain cis-gnetin H, trans-gnetin H, an derivatives thereof, as well as methods of making and using said compositions, are provided. cis-gnetin H and/or trans-gnetin H can be used in purified form or as a plant extract.Type: ApplicationFiled: February 1, 2019Publication date: September 26, 2019Applicant: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Ying GAO, Elliot ALTMAN, Anthony FARONE, Hyo PARK
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Publication number: 20190169151Abstract: Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.Type: ApplicationFiled: April 11, 2017Publication date: June 6, 2019Applicant: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Jeannie STUBBLEFIELD, Zachary E. TAYLOR, Scott HANDY, Mary FARONE, Erin MCCLELLAND, Caleb SUTTON, Anthony FARONE, Hyo PARK, Danielle ARAUJO, Anthony NEWSOME
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Publication number: 20180221329Abstract: The cis- and trans-isomers of the plant-derived compound suffruticosol D are shown to have anticancer properties. Therapeutic and prophylactic compositions that contain cis- or trans-suffruticosol D, as well as methods of making and using said compositions, are provided. The cis- or /ra«s-suffruticosol D can be used in purified form or as a plant extract.Type: ApplicationFiled: July 28, 2016Publication date: August 9, 2018Applicant: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Ying Gao, Elliot Altman
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Publication number: 20170360722Abstract: 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), as well as variants, derivatives, analogs, modifications, and conjugates thereof, are identified as therapeutic agents for treating or preventing human cancers and precancerous conditions. DMDD can be isolated from the root of Averrhoa carambola L., commonly known as starfruit. Pharmaceutical and nutraceutical compositions, as well as dietary supplements, are provided, as are methods of administration and treatment.Type: ApplicationFiled: December 9, 2015Publication date: December 21, 2017Applicant: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Ying GAO, Elliot ALTMAN
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Publication number: 20170360875Abstract: Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, as well as methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation in viral infection, I are described. For example, polypeptides and other compounds can be used to inhibit immune complex formation in a subject who has been diagnosed as having or is suspected of having an Ebola virus infection, a subject who has been diagnosed as having or is suspected of having an influenza virus infection, or a subject who has been diagnosed as having or is suspected of having a hepatitis virus infection.Type: ApplicationFiled: December 22, 2015Publication date: December 21, 2017Applicant: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Neil M. Bodie, Hyo Park, Elliot Altman
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Publication number: 20170326098Abstract: The cis-isomer and trans-isomers of the plant-derived compound gnetin H are shown have anticancer properties, anti-inflammatory properties, and low toxicity. Therapeutic and prophylactic compositions that contain cis-gnetin H, trans-gnetin H, an derivatives thereof, as well as methods of making and using said compositions, are provided, cis-gnetin H and/or trans-gnetin H can be used in purified form or as a plant extract.Type: ApplicationFiled: September 22, 2015Publication date: November 16, 2017Applicant: MIDDLE TENNESSEE STATE UNIVERSITYInventors: Ying GAO, Elliot ALTMAN, Anthony FARONE, Hyo PARK
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Publication number: 20170268032Abstract: A solid supported branched linker assay system, including an alpha compound and a beta compounds reversibly tethered to a solid support; a branched linker coupled to the solid support that tethers the alpha and beta compounds to the solid support; the branched linker having two cleavable linkers that are chemically distinct from one another, wherein a first chemically distinct linker tethers the ? compound to the branched linker and a second chemically distinct linker tethers the ? compound to the branched linker; and at least two means for cleaving the chemically distinct linkers, wherein a first cleavage means is configured to selectively cleave a first chemically distinct linker and a second cleavage means is configured to selectively cleave a second chemically distinct linker.Type: ApplicationFiled: March 20, 2017Publication date: September 21, 2017Applicant: Middle Tennessee State UniversityInventors: Kevin L. Bicker, Kevin J. Fisher, Ashley E. Corson
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Publication number: 20150129426Abstract: A zinc oxide-carbon nanotube composite is provided, the nanotube composite being selective and sensitive for detection of hydrogen peroxide, which is important for screening for early cancer detection, monitoring cardiovascular disease, detecting onset of food spoilage, and enzymatic reactions that produce hydrogen peroxide as a byproduct. Also provided are methods using said zinc oxide-carbon nanotube composite.Type: ApplicationFiled: June 4, 2013Publication date: May 14, 2015Applicant: Middle Tennessee State UniversityInventors: Charles C. Chusei, Mulugeta Wayu, Ryan T. Spidle, Adam K. Wanekaya