Patents Assigned to MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ
  • Method for selection of hDIS3 PIN domain inhibitors and use of hDIS3 PIN domain inhibitors for cancer treatment
    Patent number: 9611514
    Abstract: The present invention relates to a method for selection or screening of hDIS3 PIN domain inhibitors, yeast strain and cell line used in such methods It also relates to new therapeutic agents selected hDIS3 PIN domain inhibitors and uses thereof in the treatment of cancers having mutations inhDIS3 RNB domain, especially multiple myeloma. The invention also relates to composition comprising new therapeutic agent hDIS3 PIN domain inhibitor and method for inducing synthetic lethality in a cancer cell.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: April 4, 2017
    Assignees: INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK, ONCOARENDI THERAPEUTICS SP ZOO, MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE
    Inventors: Andrzej Dziembowski, Rafal Tomecki, Karolina Drazkowska, Roman Szczesny, Krystian Stodus, Weronika Jonko, Marcin Nowotny, Adam Golebiowski, Jacek Olczak
  • Method of peptide hydrolysis, peptidase, the composition for use as a bacteriostatic and bactericidal agent, a kit and the uses of the active form of LytM from or derivatives thereof
    Patent number: 9487771
    Abstract: The invention relates to new method of peptide hydrolysis, in particular of the cell walls of Gram-positive bacteria, wherein the active form of LytM or derivative thereof is contacted with a peptide substrate, preferably with the cell walls of Gram-positive bacteria, in an aqueous environment of conductivity lower than 10 mS/cm. The invention also relates to composition comprising active form of LytM or derivative thereof and new uses of active form of LytM or derivative thereof.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: November 8, 2016
    Assignee: MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ
    Inventors: Izabela Sabala, Matthias Bochtler
  • Sequence-specific engineered ribonuclease H and the method for determining the sequence preference of DNA-RNA hybrid binding proteins
    Patent number: 9353358
    Abstract: The subject of the invention is the ribonuclease which cleaves RNA strand in DNA-RNA hybrids, wherein ribonuclease comprises fusion protein comprising catalytic domain of RNase HI (RNase HI) or derivative thereof with a zinc finger DNA-RNA hybrid binding domain, and wherein the zinc finger binding domain has the ability to bind to specific sequences in the DNA-RNA hybrid. The invention also relates to new methods for determination of the sequence preference of DNA-RNA hybrid binding protein(s) or its domain(s) and allows determining the sequence recognized by sequence specific binding protein in the DNA-RNA hybrid.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: May 31, 2016
    Assignee: MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ
    Inventors: Janusz Marek Bujnicki, Agata Agnieszka Sulej, Krzysztof Jerzy Skowronek, Marcin Nowotny
  • METHOD OF PEPTIDE HYDROLYSIS, PEPTIDASE, THE COMPOSITION FOR USE AS A BACTERIOSTATIC AND BACTERICIDAL AGENT, A KIT AND THE USES OF THE ACTIVE FORM OF LYTM FROM S. AUREUS OR DERIVATIVES THEREOF
    Publication number: 20140044698
    Abstract: The invention relates to new method of peptide hydrolysis, in particular of the cell walls of Gram-positive bacteria, wherein the active form of LytM or derivative thereof is contacted with a peptide substrate, preferably with the cell walls of Gram-positive bacteria, in an aqueous environment of conductivity lower than 10 mS/cm. The invention also relates to composition comprising active form of LytM or derivative thereof and new uses of active form of LytM or derivative thereof.
    Type: Application
    Filed: October 17, 2013
    Publication date: February 13, 2014
    Applicant: MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ
    Inventors: Izabela Sabala, Matthias Bochtler