Patents Assigned to MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE
  • Method for selection of hDIS3 PIN domain inhibitors and use of hDIS3 PIN domain inhibitors for cancer treatment
    Patent number: 9611514
    Abstract: The present invention relates to a method for selection or screening of hDIS3 PIN domain inhibitors, yeast strain and cell line used in such methods It also relates to new therapeutic agents selected hDIS3 PIN domain inhibitors and uses thereof in the treatment of cancers having mutations inhDIS3 RNB domain, especially multiple myeloma. The invention also relates to composition comprising new therapeutic agent hDIS3 PIN domain inhibitor and method for inducing synthetic lethality in a cancer cell.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: April 4, 2017
    Assignees: INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK, ONCOARENDI THERAPEUTICS SP ZOO, MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE
    Inventors: Andrzej Dziembowski, Rafal Tomecki, Karolina Drazkowska, Roman Szczesny, Krystian Stodus, Weronika Jonko, Marcin Nowotny, Adam Golebiowski, Jacek Olczak