Patents Assigned to Miles Inc.
  • Patent number: 5450770
    Abstract: An integrated rotary drive apparatus for driving an element to be rotated in a controlled manner, comprises; a coupling shaft coupled to the element to be rotated, a drive shaft having a hollow portion within which the coupling shaft engages, a shaftless DC motor armature coupled to the coupling shaft for directly driving the coupling shaft, and a flywheel and rotary encoder disk coupled to the drive shaft to rotate therewith. The integrated rotary drive further includes a first enclosure section, for mounting to a non-rotating frame member for supporting the integrated rotary drive, and a second enclosure section mounted to the first enclosure section, for supporting a non-rotating optical encoder reader in proximity to the rotary encoder disk for providing a feedback signal, and for supporting a non-rotating DC motor stator in proximity to the DC motor armature for driving the DC motor armature when a DC current is applied to the stator.
    Type: Grant
    Filed: April 9, 1993
    Date of Patent: September 19, 1995
    Assignee: Miles Inc.
    Inventors: Arthur J. Bellemore, Thomas K. Hebert, David B. Larsen
  • Patent number: 5449898
    Abstract: The high spatial resolution area array detection readhead and method for using the same involve modifying an existing area array detection readhead to provide improved spatial resolution within the sample detection area. One modification involves reducing the field of view of the area array detection readhead. The reduction in the field of view increases pixel spatial resolution because the same number of pixels in the area array detector cover a smaller area. This reduction can be achieved by changing the magnification of the lens of the area array detection readhead or by moving the sample detection area closer to the area array detection readhead. The next modification involves properly aligning the reduced field of view within the sample detection area to take advantage of the improved pixel resolution.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: September 12, 1995
    Assignee: Miles Inc.
    Inventor: Andrew J. Dosmann
  • Patent number: 5449700
    Abstract: The present invention is directed to an isocyanate reactive mixture of specified amounts of a) a polyether polyol having a hydroxyl functionality of from 4 to 8 and having a hydroxyl number of from about 300 to about 450, b) a polyether polyol having a hydroxyl functionality of from 4 to 8 and having a hydroxyl number of from about 50 to about 200, and wherein at least 75% of the hydroxyl groups are primary hydroxyl groups, c) an adduct of a mono-, di-, or trialkanolamine and propylene oxide, said adduct having a hydroxyl number of from about 100 to about 800, and d) a polyoxyalkylene polyamine having a molecular weight of from about 2000 to about 5000, and containing from 2 to 3 primary amino groups. The invention is also directed to water-blown, energy absorbing foams made from the isocyanate reactive mixture.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: September 12, 1995
    Assignee: Miles Inc.
    Inventors: Charles M. Milliren, Ronald Zibert
  • Patent number: 5440003
    Abstract: Disclosed herein are processes for the production of allophanate-modified diphenylmethane diisocyanate prepolymers and the products produced by the processes which are both stable and liquid at 25.degree. C. by reacting (i) 4,4'-diphenyl-methane diisocyanate containing from 2 to 60% by weight 2,4'-MDI and less than 6% by weight of the 2,2'-MDI with (ii) an aromatic alcohol containing between 6 and 18 carbon atoms such as phenol, with the resulting product being converted to the allophanate having an isocyanate group content of from 12 to 32% by weight.
    Type: Grant
    Filed: September 2, 1993
    Date of Patent: August 8, 1995
    Assignee: Miles Inc.
    Inventor: William E. Slack
  • Patent number: 5440038
    Abstract: Substituted 4-amino-1,2,4-triazine-5-ones are purified to remove unwanted N-isomers by maintaining the crude product at a temperature of from about 55.degree. C. to about 70.degree. C. in the presence of a hydroxide, preferably an alkali metal hydroxide for at least 0.5 hour.
    Type: Grant
    Filed: December 7, 1993
    Date of Patent: August 8, 1995
    Assignee: Miles Inc.
    Inventors: Vidyanatha A. Prasad, David M. Mayes, Peter E. Newallis, Karl G. Steinbeck
  • Patent number: 5438106
    Abstract: A NCO-free, free radical-curable polyurethane coating composition which is particularly suitable for application on heat sensitive substrate is disclosed. The coating contains an allylether-capped isocyanate prepolymer and at least one additional isocyanate prepolymer which is capped with a hydroxyalklyl(meth)acrylate. The composition of the invention yields coatings having good dry time and hardness. An additional embodiment relates to aqueous dispersions of the composition of the invention and to films made therefrom.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: August 1, 1995
    Assignee: Miles Inc.
    Inventors: Stanley F. Siranovich, Manfred Bock, Lanny D. Venham, Terry A. Potter
  • Patent number: 5438003
    Abstract: A reagent composition which includes organic cationic dyes for staining the reticulocytes in a blood sample and buffer solutions for maintaining a pH of about 6 to about 9 is provided. The dyes may be the blue absorption dyes Oxazine 750 or New Methylene Blue. A zwitterionic surfactant is included in the reagent composition for isovolumetric sphering of the reticulocytes and erythrocytes. The reagent composition and whole blood sample mixture are passed through the sensing region of a flow cytometer. The light scattered and absorbed by each cell is measured; the erythrocytes can be distinguished from reticulocytes and the volume, hemoglobin concentration and the hemoglobin content of each reticulocyte or erythrocyte, and the mean cell volume, mean corpuscular hemoglobin concentration, and mean cell hemoglobin of the reticulocytes or erythrocytes are calculated from the measured cell-by-cell volume and hemoglobin concentration.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: August 1, 1995
    Assignees: Miles Inc., Mount Sinai School of Medicine of the City University of New York
    Inventors: Gregory M. Colella, Daniel Ben-David, Albert Cupo, Sophie S. Fan, Gena Fischer, Grace E. Martin, Leonard Ornstein
  • Patent number: 5429735
    Abstract: A method of making and an amperometric electrode are provided. An electrode carbon ink is applied to a polymer substrate to form a working electrode. The substrate carrying the working electrode is placed in a gas plasma cleaner, such as an oxygen or nitrogen plasma, to clean the working electrode. A high radio frequency signal excites the gas plasma for a short exposure time in a range between 10 seconds and 30 seconds. Then a reagent layer is deposited to the plasma treated working electrode.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: July 4, 1995
    Assignee: Miles Inc.
    Inventors: Larry D. Johnson, Alison J. Murray, Matthew K. Musho
  • Patent number: 5428124
    Abstract: Storage stable, liquid prepolymers of diphenylmethane diisocyanate containing urea and/or biuret groups are prepared by reacting an aminocrotonate with a mixture of isocyanates having a specified diphenylmethane diisocyanate isomer content. These prepolymers have isocyanate group contents of from about 5 to about 30%.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: June 27, 1995
    Assignee: Miles Inc.
    Inventors: William E. Slack, Robert P. Yeater, Robson Mafoti, Josef Sanders
  • Patent number: 5426124
    Abstract: The present invention relates to a process for the production of polyurethane foam moldings having a compact surface skin and a density of at least 150 kg/m.sup.3 comprising foaming a polyurethane-forming starting mixture inside a mold. The starting mixture comprises organic blowing agents which correspond to one or both of the following general formulas:HOOC--R--COOH (I)wherein: R represents a CH.sub.2 group or a CH.dbd.CH group;and ##STR1## wherein: R.sup.1 and R.sup.2 independently of one another represent either a hydrogen atom or a C.sub.1-6 alkyl radical wherein the hydrogen atoms may be partly substituted by OH groups.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: June 20, 1995
    Assignees: Bayer Aktiengesellschaft, Miles Inc.
    Inventors: Alfred Neuhaus, Peter Haas, Majid Daneshvar
  • Patent number: 5426127
    Abstract: Rigid polyurethane foams are produced by reacting an organic polyisocyanate with an amine-based polyether polyol in the presence of a catalyst, a hydrogen-containing fluorocarbon and a minor amount of water. These foams are characterized by K-factors which are about 0.135 BTU-in./hr.ft..sup.2 .degree.F. or less.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: June 20, 1995
    Assignee: Miles Inc.
    Inventor: Herman P. Doerge
  • Patent number: 5424075
    Abstract: The invention discloses a swallow tablet which is capable of disintegrating within less than about fifteen minutes and providing fast delivery of therapeutic drugs. The delivery system is composed of between 0.250 and 1.0 Gm of an alkali metal or alkaline-earth metal salt of an edible organic acid. A preferred delivery system is trisodium citrate.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: June 13, 1995
    Assignee: Miles Inc.
    Inventors: Lawrence J. Daher, Manley A. Paulos
  • Patent number: 5424215
    Abstract: The detection of protein is accomplished using novel composition and method involving phenolsulfonephthalein protein error indicator, buffer and an aliphatic ether-polycarbonate present in an amount equal to or less than ten percent by weight.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: June 13, 1995
    Assignee: Miles Inc.
    Inventors: James P. Albarella, Angela A. Michaels, Michael J. Pugia, Ronald G. Sommer
  • Patent number: 5421677
    Abstract: The invention is directed to a process of forming a ditch liner by dispensing a solidifiable liquid mixture onto a continuously moving porous blanket, applying pressure against the mixture and the coated blanket to form a continuous matrix within the blanket, laying the resulting coated blanket into a ditch before the liquid mixture has fully cured, conforming the coated blanket to the shape of the ditch, and allowing the mixture to fully cure. The improvement resides in using a reaction mixture of a polyisocyanate, up to 60% by weight of a filler, a specified polyol mixture and, optionally, a catalyst. The polyol mixture requires three different propylene oxide adducts: i) a propylene oxide adduct of an alkanolamine, ii) a propylene oxide adduct of a low molecular weight organic compound having from 3 to 8 OH groups, and iii) a propylene oxide adduct of a low molecular weight diol.
    Type: Grant
    Filed: April 7, 1994
    Date of Patent: June 6, 1995
    Assignee: Miles Inc.
    Inventors: Norbert J. Adam, Jerome B. LeFebvre
  • Patent number: 5420188
    Abstract: The present invention is directed to a mold release, a composition containing the mold release, and a process of using the mold release. The mold release comprises an internal mold release composition comprising(a) a zinc carboxylate containing from 8 to 24 carbon atoms per carboxylate group, and(b) a compatibilizer comprising an amidine group-containing compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are straight or branched, saturated or unsaturated hydrocarbon chains having up to 30 carbon atoms which may be substituted by ether groups, ester groups, amide groups or amidine groups and may also be terminated by isocyanate-reactive groups such as hydroxyl or amino groups, R.sub.4 corresponds to the definition of R.sub.1, R.sub.2 and R.sub.3, but may additionally represent an aromatic substituent having 6 to 15 carbon atoms or may represent the group --NR.sub.2 R.sub.3, with the proviso that when R.sub.4 represents the group --NR.sub.2 R.sub.3, R.sub.1 can be hydrogen, and wherein R.sub.
    Type: Grant
    Filed: December 31, 1992
    Date of Patent: May 30, 1995
    Assignee: Miles Inc.
    Inventor: John E. Dewhurst
  • Patent number: 5419906
    Abstract: The effects of Cohn-Oncley cold alcohol fractionation on infectivity of two prototype retroviruses, mouse xenotropic type C and the LAV strain of AIDS retrovirus result in a significant reduction in retrovirus titer. At least a 100,000-fold reduction of LAV was obtained when fractionating plasma to fraction II. Adjustment to pH 4.0 at filtrate III was as effective for viral inactivation as was precipitation of fraction II from filtrate III with 25% ethanol. Liquid immunoglobulin preparations spiked with LAV and incubated at 27.degree. C. for 3 days resulted in an additional 1,000-10,000-fold reduction of LAV titer. Our results support the clinical and epidemiological evidence that therapeutic immunoglobulin preparations prepared by Cohn-Oncley cold ethanol processing (at least about 18% v/v alcohol, pH.ltoreq.5.4) and then stored at a pH equal to or less than about 5.4 and a temperature of at least 27.degree. C. for at least 3 days, do not transmit retroviruses such as the LAV strain of the AIDS virus.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: May 30, 1995
    Assignee: Miles Inc.
    Inventors: Gautam Mitra, Milton M. Mozen, Robert E. Louie
  • Patent number: 5417880
    Abstract: The present invention is directed to an isocyanate reactive mixture of specified amounts of a) a polyether polyol having a hydroxyl functionality of from 4 to 8 and having a hydroxyl number of from about 300 to about 450, b) a polyether polyol having a hydroxyl functionality of from 4 to 8 and having a hydroxyl number of from about 50 to about 200, and wherein at least 75% of the hydroxyl groups are primary hydroxyl groups, c) an adduct of a mono-, di-, or trialkanolamine and propylene oxide, said adduct having a hydroxyl number of from about 100 to about 800, and d) a polyoxyalkylene polyamine having a molecular weight of from about 2000 to about 5000, and containing from 2 to 3 primary amino groups. The invention is also directed to water-blown, energy absorbing foams made from the isocyanate reactive mixture.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: May 23, 1995
    Assignee: Miles Inc.
    Inventors: Charles M. Milliren, Ronald Zibert
  • Patent number: 5415802
    Abstract: A novel isocyanate reactive mixture is described which allows for the preparation of energy absorbing foams which meet Chrysler specification DC-640. The reactive mixture contains a) a filled polyol, b) a propylene oxide adduct of a mono-, di-, or trialkanolamine and c) a polyoxyalkylene polyamine. Foams prepared from the reactive mixture are also described.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: May 16, 1995
    Assignee: Miles Inc.
    Inventors: Charles M. Milliren, Ronald Zibert
  • Patent number: 5414054
    Abstract: A thermoplastic copolycarbonate resin having improved low temperature impact strength and a process for the preparation of the resin are disclosed. Accordingly the structure of the copolycarbonate contains(i) units of the formula ##STR1## wherein D is a divalent residue of a dihydroxy compound, and (ii) units of the formula ##STR2## wherein m is 1-90, n is 5-300, R is an alkyl or a phenyl radical p is 2-12 and q is 2-20. The preparation of the copolycarbonate entails reactive blending of polycarbonate with a suitable lactone siloxane copolymer in the presence of a transesterification catalyst.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: May 9, 1995
    Assignee: Miles Inc.
    Inventors: Erik H. Jonsson, Rick L. Archey, Robert J. Kumpf, Aaron D. Meltzer, Harald Pielartzik, Raymond A. Yourd
  • Patent number: D359357
    Type: Grant
    Filed: August 23, 1993
    Date of Patent: June 13, 1995
    Assignee: Miles Inc.
    Inventors: William E. Bigler, David L. Boger, James F. Caruso, Kenneth D. Collister, Lester W. Doyle, Cynthia S. Postma, Ralph G. Priddy, Bryce Rutter, Robert L. Terry, Raymond M. Werner