Abstract: The invention provides a method to prepare a graft comprising a recellularized extracellular matrix of a mammalian liver, liver lobe or portion thereof, and a method of using the recellularized extracellular matrix of a mammalian liver, liver lobe or portion thereof.
Abstract: The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.
Type:
Grant
Filed:
September 6, 2017
Date of Patent:
March 22, 2022
Assignees:
Mayo Foundation for Medical Education and Research, Miromatrix Medical Inc.
Inventors:
Jeffrey Ross, Anne Young, Allie Haarstad, Scott Nyberg
Abstract: The invention provides for methods and materials to decellularize a solid organ and to recellularize such a decellularized organ to thereby generate a solid organ.
Abstract: The invention provides for methods and materials to decellularize a solid organ and to recellularize such a decellularized organ to thereby generate a solid organ.
Abstract: A method to provide an inflated decellularized extracellular matrix of a mammalian organ or a vascularized portion thereof, or a mammalian vascularized tissue or a vascularized portion thereof, an inflated decellularized extracellular matrix of a mammalian organ or a vascularized portion thereof, or a mammalian vascularized tissue or a vascularized portion thereof, and uses thereof, are provided.
Type:
Grant
Filed:
March 24, 2016
Date of Patent:
May 22, 2018
Assignee:
Miromatrix Medical Inc.
Inventors:
Aleksandr Katane, Dominique Seetapun, Jeffrey Ross
Abstract: The invention provides a method for preparing a perfusion based 3D cell culture system, a recellularized matrix culture system, and methods of using the culture system.