Abstract: The invention provides a replicable genetic package displaying a cyclic peptide having at least one intramolecular bond between amino acid side chains. Also provided are a method of preparing such a genetic package displaying cyclic peptides having at least one intramolecular bond. Further provided is a library of replicable genetic packages displaying cyclic peptides each having at least one intramolecular cyclic bond between amino acid side chains; and a method of producing such a library.

Abstract: An immobilizer device is provided for preventing the travel of a wheel, particularly the wheel of a vehicle. The immobilizer device utilizes an elongated pin to pass through a portion or aperture of the wheel, and the immobilizer device prevents travel of the wheel by acting as a chock. Some embodiments of the immobilizer device comprise an indexing feature to guide the elongated pin into an aperture and a receiver tube to guide the elongated pin into another aperture. Then the elongated pin may be placed in a locked position to secure the immobilizer device to the wheel.

Abstract: The present invention concerns a sealing system for a tool holder of a fluid-assisted axial machining or milling machine, including:—at least first and second seals contributing to define a space for the flow of fluid to at least one inner channel of the tool, one of the seals being applied to the tool or an optional adapter carrying the tool and the other seal a) being applied to the tool or to the adapter carrying the tool or b) being applied to a surface spaced apart from the tool and rotating with same, with 0.3?Do/Djmax for Do in the interval [1; 3] in mm and 0.5?Do/Djmax for Do in the interval [3; 20] in mm, where Do is the diameter of the tool facing this other seal and Djmax is the internal diameter of this seal.

Abstract: A machining method for at least one shaping machining operation can include carrying out a machining operation over a first distance using a cutting tool which is subjected to axial oscillations as it moves forward, then reducing the amplitude of the axial oscillations while continuing to drive the cutting tool in terms of rotation.

Abstract: The invention provides a replicable genetic package displaying a cyclic peptide having at least one intramolecular bond between amino acid side chains. Also provided are a method of preparing such a genetic package displaying cyclic peptides having at least one intramolecular bond. Further provided is a library of replicable genetic packages displaying cyclic peptides each having at least one intramolecular cyclic bond between amino acid side chains; and a method of producing such a library.

Abstract: The present invention relates to a microneedle, to a mould for producing same, and to a production method for same. More specifically, the present invention concerns a microneedle for causing a skin-beautifying substance or drug to be absorbed via the skin, to a plastic mould for producing same, and to a production method for same.

Abstract: The present invention provides an axial machining device comprising a tool-carrier spindle rotatable in a housing, the housing housing a transmission system causing the spindle to advance automatically relative to the housing under the effect of the tool-carrier spindle being driven in rotation, the transmission system including an advance gearwheel screwed onto the spindle, the device including a resilient return member urging the advance gearwheel in a first axial direction opposite to the advance direction of the spindle, and also including a first rolling bearing having rolling members rolling on an undulating raceway having an axial component, thereby periodically urging the advance gearwheel to move in a second direction opposite to the first, such that rotation of the spindle is accompanied by axial vibratory motion.

Abstract: A machining method for at least one shaping machining operation can include carrying out a machining operation over a first distance using a cutting tool which is subjected to axial oscillations as it moves forward, then reducing the amplitude of the axial oscillations while continuing to drive the cutting tool in terms of rotation

Abstract: The present invention provides an axial machining device comprising a tool-carrier spindle rotatable in a housing, the housing housing a transmission system causing the spindle to advance automatically relative to the housing under the effect of the tool-carrier spindle being driven in rotation, the transmission system including an advance gearwheel screwed onto the spindle, the device including a resilient return member urging the advance gearwheel in a first axial direction opposite to the advance direction of the spindle, and also including a first rolling bearing having rolling members rolling on an undulating raceway having an axial component, thereby periodically urging the advance gearwheel to move in a second direction opposite to the first, such that rotation of the spindle is accompanied by axial vibratory motion.

Abstract: The present invention relates to a microneedle cap system to be mounted to a container containing an active substance. The system comprises a container cap unit and a microneedle unit, which, among others, allows the active substance to be delivered in a desired amount.

Abstract: A microneedle drug delivery system comprises: a housing having an opening formed in the bottom wall thereof; a microneedle device seated in the opening of the housing in such a fashion as to be hermetically sealed with the bottom wall of the housing; a drug-containing capsule mounted in the housing 1 in such a fashion as to be positioned spaced apart from the microneedle device. With this system, an active agent (or drug) can be effectively delivered into a subject in need.

Abstract: A lancet block comprises a lancet comprising a cam projection and a lancet housing receiving the lancet in such a fashion that the lancet can be vertically moved relatively with respect to the lancet housing. A top wall of the lancet housing and a side wall of the lancet housing corresponding to the cam projection of the lancet are formed of a thin membrane made of a material capable of being easily disrupted and a bottom wall of the lancet housing is formed of a thin membrane made of a material capable of being easily disrupted by a tip of the needle of the lancet. With this lancet block, it is possible to, e.g., provide convenient and sanitary use of a lancet, avoid a risk of any injury by a needle tip, prevent bacterial infection due to such injury, and reduce manufacturing costs.

Abstract: The present invention relates to a microneedle for delivering active agent or agents. The microneedle comprises a body a body having a base at one end thereof and a tip portion at the other end thereof; a pair of projections connected to a side of the body and having a base at one end thereof and a tip portion at the other end thereof; and a vertical groove defined by the body and the pair of projections. The distance between outer edges of the pair of projections is formed to become smaller towards the tip portion than the distance between outer edges of the body, and the upper end of each of the pair of projections is shorter than that of the body such that a free space is formed between the outer edges of the body and the pair of projections.

Abstract: A container for transdermal delivery of an active agent or agents using microneedles includes a reservoir adapted to receive a substance containing an active agent or agents; and a cover member adapted to cover an entrance of the reservoir, the cover member comprising one or more through-holes formed therein and one or more microneedles formed thereon. With the container, transdermal delivery can be made conveniently, easily, and effectively.

Abstract: A microneedle-replaceable roller and stamp comprises a main body having a handle portion and a microneedle plate or sheet that is detachably mounted to the main body. According to the roller and stamp, inexpensive and sanitary application can be ensured.

Abstract: A stimuli-responsive polymer derivative utilizing keto-enol tautomerization. Also disclosed are a simple process for producing an N-acyl(meth)acrylamide derivative which can be used as a monomer for the stimuli-responsive polymer, a process for the production of an intermediate thereof, and an intermediate thus produced.

Abstract: Methods and systems for supplying supplemental oxygen to patients for use in sub-acute care which maintains healthy blood oxygen content in the patients by controlled dosing of oxygen with a measured response to the patient's actual blood oxygen content are disclosed. The dosing can be provided by simple ON/OFF control over the delivery of oxygen or the amount of oxygen delivered to the patient with each inhalation can be varied in response to the patient's need as determined by a more sophisticated control scheme, such as a PID loop control algorithm, that utilizes the difference between the patient's actual blood oxygen content and a target blood oxygen content and/or trends in the blood oxygen content. The systems and methods are particularly directed at patients receiving supplemental oxygen in a sub-acute care environment.

Abstract: A two-piece vehicle immobilizing device adapted for removable interconnection to a vehicle wheel assembly. The vehicle immobilizing device utilizes an outer arm, an inner arm with inner and outer indexing stops, an engagement dome, and a securing mechanism that provides engagement to the vehicle wheel assembly to prevent unauthorized removal.

Abstract: The present invention is adapted to immobilize a vehicle by utilizing a pair of selectively interconnected chocks that are placed fore and aft of a tire. The chocks are preferably used to secure aircraft and/or aircraft ground support equipment from unauthorized motion in airport parking areas.