Abstract: The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products.
Type:
Application
Filed:
December 12, 2014
Publication date:
November 12, 2015
Applicant:
MITOMICS INC.
Inventors:
Andrew Harbottle, Gabriel Dakubo, Ryan L. Parr, Jennifer Creed, Brian Reguly, Kerry Robinson
Abstract: The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
Type:
Application
Filed:
September 17, 2014
Publication date:
January 1, 2015
Applicant:
MITOMICS INC.
Inventors:
Ryan Parr, Jennifer Creed, Kerry Robinson, Andrea Maggrah, Katrina Maki, Gabriel Dakubo, Brian Reguly, Andrew Harbottle, Jude Alexander
Abstract: The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and the resulting translation products (proteins) for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided.
Type:
Grant
Filed:
March 29, 2010
Date of Patent:
May 6, 2014
Assignee:
Mitomics Inc.
Inventors:
Ryan Parr, Gabriel Dakubo, Andrew Harbottle, Brian Reguly, Jennifer Creed, Kerry Robinson, Daniel Klein
Abstract: The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying a mtDNA mutation in the sample and comparing the level of the mtDNA mutation present in the sample with a reference value The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes Further, said methods may be also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
Abstract: The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and the resulting translation products (proteins) for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided.
Type:
Application
Filed:
March 29, 2010
Publication date:
March 7, 2013
Applicant:
MITOMICS INC.
Inventors:
Ryan Parr, Andrew Harbottle, Brian Reguly, Jennifer Creed, Kerry Robinson, Daniel Klein
Abstract: Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melonoma skin cancer are provided.
Type:
Application
Filed:
August 30, 2011
Publication date:
March 8, 2012
Applicant:
MITOMICS INC.
Inventors:
Ryan Parr, Robert Thayer, Gabriel Dakubo, Jennifer Maki, Kerry Robinson, Andrea Maggrah, Brian Reguly, Andrew Harbottle, Mark Birch-Machin
Abstract: Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melanoma skin cancer are provided.
Type:
Grant
Filed:
October 18, 2007
Date of Patent:
August 30, 2011
Assignee:
Mitomics Inc.
Inventors:
Ryan Parr, Robert Thayer, Gabriel Dakubo, Jennifer Maki, Kerry Robinson, Andrea Maggrah, Brian Reguly, Andrew Harbottle, Mark Birch-Machin
Abstract: The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photoageing, ultraviolet radiation (UVR) damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
Type:
Application
Filed:
October 14, 2008
Publication date:
August 18, 2011
Applicant:
MITOMICS INC.
Inventors:
Ryan PARR, Mark BIRCH-MACHIN, Andrew HARBOTTLE, Robert THAYER, Jennifer CREED, Andrea MAGGRAH, Kerry ROBINSON, Gabriel DAKUBO, Brian REGULY, Katrina MAKI
Abstract: The present invention provides novel mitochondrial fusion transcripts and the parent mutated mtDNA molecules that are useful for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided.
Type:
Application
Filed:
March 27, 2009
Publication date:
July 14, 2011
Applicant:
MITOMICS INC.
Inventors:
Ryan Parr, Brian Reguly, Gabriel Dakubo, Jennifer Creed, Kerry Robinson