Patents Assigned to Molecular BioQuest, Inc.
  • Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production
    Patent number: 5441746
    Abstract: This invention describes an electromagnetic wave-absorbing surface modified magnetic particle for use in medical applications. The magnetic particles are coated with an amphipathic organic compound and an amphipathic vesicle forming lipid. These particles may be used in a method of treatment of cancer, as well as for the treatment of infectious disease. For cancer treatment the invention comprises providing a patient said coated particles, absorbing the coated particle intracellularly into the cancer cell, and subjecting the patient to an alternating electromagnetic field to inductively heat the magnetic core particle along with the cancer cells. The inductive heating of the magnetic core particle is then continued so as to achieve an increase in intracellular temperature which selectively kills the cancer cells.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: August 15, 1995
    Assignee: Molecular BioQuest, Inc.
    Inventor: Mark S. Chagnon
  • Solid care therapeutic compositions and methods for making same
    Patent number: 5389377
    Abstract: A liposome composition which comprises a substantially uniform sized inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid. Also disclosed are novel phenyl lipid compounds which serve as the amphipathic vesicle forming lipid and methods are described for delivering a drug for slow release into the blood stream, and for targeting a selected tissue or cells with the inorganic core liposome compositions.
    Type: Grant
    Filed: October 7, 1992
    Date of Patent: February 14, 1995
    Assignee: Molecular Bioquest, Inc.
    Inventors: Mark S. Chagnon, John R. Ferris, Tracy J. Hamilton, Edwin A. Rudd, Michelle J. Carter
  • Biodegradable magnetic microclusters and methods for making them
    Patent number: 5382468
    Abstract: Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The magnetic microcluster can be used as contrast agents in NMR imaging for the production of images suitable for use in diagnosis, for in vivo delivery and targeting of drugs, as in vivo, biodegradable agents for the sequestering of free metal ions in the treatment of metal driven disease.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: January 17, 1995
    Assignee: Molecular Bioquest, Inc.
    Inventors: Mark S. Chagnon, John R. Ferris, Barry L. Fiore, Michelle J. Carter, Tracy J. Hamilton
  • Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer
    Patent number: 5225282
    Abstract: Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The magnetic microcluster can be used as contrast agents in NMR imaging for the production of images suitable for use in diagnosis, for in vivo delivery and targeting of drugs, as in vivo, biodegradable agents for the sequestering of free metal ions in the treatment of metal driven disease.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: July 6, 1993
    Assignee: Molecular BioQuest, Inc.
    Inventors: Mark S. Chagnon, John R. Ferris, Barry L. Fiore, Michelle J. Carter, Tracy J. Hamilton