Abstract: The invention relates to polysaccharide derivatives comprising a) at least one hydrophobic and b) at least one nitrogen-containing substituent; in particular, the derivative is a cellulose ether which, as substituent a), has a trialkylsilyl and, as substituent b), an aminoalkyl group. Furthermore, it relates to a process for immobilizing biomolecules on a coated sheet-like carrier material in which the biomolecules are attached at or in the coating and the coated sheet-like carrier material comprises within or outside the coating at least one such polysaccharide derivative. Additionally, in the process for preparing the mixed cellulose ether a solution of trialkylsilylcellulose in an organic solvent is admixed with a reactive aminoalkane derivative which is insoluble or only sparingly soluble in this solvent, the reaction is carried out and the end product is isolated.

Abstract: The invention relates to methods for the base sequencing of deoxyribonucleic acid or ribonucleic acid, comprising the following steps: (1) immobilising DNA or RNA single strands on a planar support; (2) focussing a laser beam on a single, immobilised single strand; (3) producing DNA or RNA complimentary strand of said immobilised, focused single strand by adding a solution containing (i) at least one luminescence-tagged nucleotide on the bases of adenine, cytosine, guanine and thymine for producing a DNA or RNA complementary strand or at least one luminescence-tagged nucleotide of the bases adenine, cytosine, guanine and uracil for producing an RNA complementary strand and (ii) a polymerase, each insertion of a luminescence-tagged nucleotide into the complementary strand being detected with a single-molecule detector and the luminescence signal of the previous luminescence-tagged nucleotide being deleted before the next luminescence-tagged nucleotide is inserted.

Abstract: The invention relates to a method for screening target-ligand interactions while using a chemical library of ligands, to the chemical library of ligands as such, to a method for producing the chemical library, as well as to the use of the chemical library for developing active agents and for developing molecular sensors. The screening method comprises the following steps: (a) measuring at least one fluorescence property of a locally addressable chemical library of ligands that is immobilized on a solid phase, whereby a molecular fluorescence sensor is bound to each ligand; (b) adding the target, and (c) measuring the same fluorescence property/properties of the chemical library as described in step (a).

Abstract: The invention relates to multiple-container systems and to the use of same for optical assays. The invention relates in particular to a multiple-container system comprising a container wall matrix (1) with continuous cavities and one or more optically transparent base plates (2) joined to the container wall matrix.aid system is characterized in that the base plates are coated with a film (3) having functional groups suitable for the covalent immobilization of molecules. The film on the base plate is preferably a Langmuir-Blodgett film, and preferably a Langmuir-Blodgett film on cellulose basis. The invention further relates to multiple-container systems comprising a container wall matrix with continuos cavities and one or more optically transparent base plates joined to the wall matrix. Said systems are characterized in that the base plates are coated with a film derivatized with receptor molecules or molecules presenting low non-specific protein adsorption.