Patents Assigned to Momenta Pharmaceuticals, Inc.
  • SACCHARIDE STRUCTURES AND METHODS OF MAKING AND USING SUCH STRUCTURES
    Publication number: 20140200339
    Abstract: Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and methods of making and using such oligosaccharides are also described.
    Type: Application
    Filed: November 8, 2013
    Publication date: July 17, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Sucharita Roy, Takashi K. Kishimoto, Ganesh Kaundinya
  • Evaluation of copolymer diethylamide
    Patent number: 8765911
    Abstract: Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: July 1, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Cuihua Liu, Shiming Dong, Xiao-Jin Xu, Jonathan C. Lansing, Yanjie Jiang
  • Evaluation of copolymer diethylamide
    Patent number: 8759484
    Abstract: Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: June 24, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Cuihua Liu, Shiming Dong, Xiao-Jin Xu, Jonathan C. Lansing, Yanjie Jiang
  • Copolymer assay
    Patent number: 8753833
    Abstract: The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: June 17, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Josephine S. D'Alessandro, Takashi Kei Kishimoto, Aileen Healy
  • CELL CULTURE PROCESS
    Publication number: 20140142286
    Abstract: A method for producing recombinant polypeptides, including antibodies, having targeted levels of carboxyl terminal (C-terminal) lysine or arginine residues is presented. The method involves culturing cells expressing said polypeptides in cell culture medium having sufficient levels of lysine, arginine, and/or agents that change intracellular pH. Culturing the cells under such conditions does not affect cell growth, cell viability, or titer.
    Type: Application
    Filed: July 6, 2012
    Publication date: May 22, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventor: Holly Prentice
  • Characterization of -linked glycans
    Patent number: 8729241
    Abstract: The present disclosure provides methods for analyzing structure and/or composition of glycoproteins and glycans of glycoproteins. Such methods can include subjecting a glycoprotein preparation to a condition that removes at least one O-linked glycan from the glycoprotein. Such methods can include subjecting a glycoprotein preparation to a condition that releases an N-glycan from the glycoprotein, e.g., prior to subjecting the glycoprotein to a condition that releases an O-glycan from the glycoprotein.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: May 20, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Cuihua Liu, Xiao-Jin Xu, Shiming Dong, Guy Dellorusso
  • CHARACTERIZATION OF N-GLYCAN MIXTURES BY NUCLEAR MAGNETIC RESONANCE
    Publication number: 20140127735
    Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.
    Type: Application
    Filed: January 14, 2014
    Publication date: May 8, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Becatti, Scott Bailey, Carlos J. Bosques
  • Analysis of sulfated polysaccharides
    Patent number: 8715953
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: May 6, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ganesh Kaundinya, Zachary Shriver, Mallikarjun Sundaram, Yi-wei Qi, Ram Sasisekharan
  • CELL CULTURE PROCESS
    Publication number: 20140120583
    Abstract: Polypeptides having target levels of C-terminal variants are described.
    Type: Application
    Filed: January 8, 2014
    Publication date: May 1, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventor: Holly Prentice
  • MODIFIED GLYCOPROTEINS
    Publication number: 20140112910
    Abstract: Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described.
    Type: Application
    Filed: May 18, 2012
    Publication date: April 24, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Brian Edward Collins, Maurice Gaston Hains, Nathaniel J. Washburn, James Meador, Sean Smith, Naveen Bhatnagar
  • EVALUATING HEPARIN PREPARATIONS
    Publication number: 20140114056
    Abstract: Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature, wherein, e.g., the structural signature is indicative of the methods used to make the heparin preparation.
    Type: Application
    Filed: February 21, 2012
    Publication date: April 24, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Nur Sibel Gunay, Miroslaw Lech, Sucharita Roy, John Schaeck, Jennifer Ozug, Daniela Beccati, Ishan Capila
  • Multi-dimensional chromatographic methods for separating N-glycans
    Patent number: 8703498
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: April 22, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
  • GLYCOSYL TRANSFERASE FROM CHINESE HAMSTER AND RELATED METHODS
    Publication number: 20140087392
    Abstract: A glycosyl transferase from Chinese hamster and related methods are described.
    Type: Application
    Filed: November 6, 2013
    Publication date: March 27, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventor: James W. Meador, III
  • ANALYSIS OF AMINO ACID COPOLYMER COMPOSITIONS
    Publication number: 20140065652
    Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.
    Type: Application
    Filed: September 5, 2013
    Publication date: March 6, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
  • MULTI-DIMENSIONAL CHROMATOGRAPHIC METHODS FOR SEPARATING N-GLYCANS
    Publication number: 20140065716
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Application
    Filed: November 8, 2013
    Publication date: March 6, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
  • Characterization of N-glycan mixtures by nuclear magnetic resonance
    Patent number: 8663999
    Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: March 4, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Becatti, Scott Bailey, Carlos J. Bosques
  • ANALYSIS OF SULFATED POLYSACCHARIDES
    Publication number: 20140057358
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Application
    Filed: November 1, 2013
    Publication date: February 27, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Ganesh Kaundinya, Zachary Shriver, Mallikarjun Sundaram, Yi-wei Qi, Ram Sasisekharan
  • In-Process Control for the Manufacture of Glatiramer Acetate
    Publication number: 20140051830
    Abstract: The present disclosure provides methods for manufacturing or producing glatiramer acetate having a Mp of 5000-9000 Da.
    Type: Application
    Filed: October 28, 2013
    Publication date: February 20, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Mani S. Iyer, Harper Kaminski
  • EVALUATION OF COPOLYMER DIETHYLAMIDE
    Publication number: 20140045204
    Abstract: Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
    Type: Application
    Filed: September 6, 2013
    Publication date: February 13, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Cuihua Liu, Shiming Dong, Xiao-Jin Xu, Jonathan C. Lansing, Yanjie Jiang
  • GAL ALPHA 1-3GAL-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS
    Publication number: 20140045212
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Application
    Filed: October 17, 2013
    Publication date: February 13, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos J. Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu