Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film. The invention further relates to edible multi-layer films that dissolve in water. In particular, the edible multi-layer films have a first water-soluble film layer and one or more additional water-soluble film layers in at least partial face-to-face engagement with the first film layer.
Type:
Application
Filed:
January 9, 2018
Publication date:
May 24, 2018
Applicant:
MonoSol Rx, LLC
Inventors:
Richard C. Fuisz, Joseph M. Fuisz, Garry L. Myers
Abstract: The present invention relates to rapid dissolve thin film drug delivery compositions for the oral administration of active components. The active components are provided as taste-masked or controlled-release coated particles uniformly distributed throughout the film composition. The compositions may be formed by wet casting methods, where the film is cast and controllably dried, or alternatively by an extrusion method.
Type:
Grant
Filed:
February 21, 2017
Date of Patent:
April 3, 2018
Assignee:
MonoSol Rx, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
Abstract: Methods and packages for storing film strips while reducing or eliminating stress cracking during storage, including use of packages having an inner surface made from polymeric materials exhibiting various physical properties and including films and pouches that are annealed.
Abstract: The present invention relates to water-soluble films incorporating anti-tacking agents and methods of their preparation. Anti-tacking agents may improve the flow characteristics of the compositions and thereby reduce the problem of film adhering to a user's mouth or to other units of film. In particular, the present invention relates to edible water-soluble delivery systems in the form of a film composition including a water-soluble polymer, an active component selected from cosmetic agents, pharmaceutical agents, vitamins, bioactive agents and combinations thereof and at least one anti-tacking agent.
Type:
Grant
Filed:
February 21, 2017
Date of Patent:
January 2, 2018
Assignee:
MonoSol Rx, LLC
Inventors:
Garry L. Myers, Pradeep Sanghvi, Andrew Philip Verrall, Vimala Francis, Laura Brooks
Abstract: Methods and packages for storing film strips while reducing or eliminating stress cracking during storage, including use of packages having an inner surface made from polymeric materials exhibiting various physical properties and including films and pouches that are annealed.
Abstract: The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent.
Type:
Application
Filed:
March 14, 2016
Publication date:
February 9, 2017
Applicant:
MonoSol Rx, LLC
Inventors:
Garry L. MYERS, Samuel D. HILBERT, Bill J. BOONE, B. Arlie BOGUE, Pradeep SANGHVI, Madhusudan HARIHARAN
Abstract: The present invention relates to a method for forming a pharmaceutical product, such as a dissolvable film dosage form, onto a surface. Particularly, the present invention relates to a method of forming a pharmaceutical product directly onto the surface of a substrate.
Type:
Grant
Filed:
January 15, 2015
Date of Patent:
February 7, 2017
Assignee:
MonoSol Rx, LLC
Inventors:
Garry L. Myers, Beuford A. Bogue, Greg Slominski, Kevin Davidson, Laura Miloshoff
Abstract: The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent.
Abstract: The present invention relates to water-soluble films incorporating anti-tacking agents and methods of their preparation. Anti-tacking agents may improve the flow characteristics of the compositions and thereby reduce the problem of film adhering to a user's mouth or to other units of film. In particular, the present invention relates to edible water-soluble delivery systems in the form of a film composition including a water-soluble polymer, an active component selected from cosmetic agents, pharmaceutical agents, vitamins, bioactive agents and combinations thereof and at least one anti-tacking agent.
Type:
Application
Filed:
May 2, 2016
Publication date:
November 3, 2016
Applicant:
MonoSol Rx, LLC
Inventors:
Garry L. Myers, Pradeep Sanghvi, Andrew Philip Verrall, Vimala Francis, Laura Moss
Abstract: Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.
Type:
Grant
Filed:
October 8, 2013
Date of Patent:
October 25, 2016
Assignees:
MONOSOL RX, LLC, MIDATECH LIMITED
Inventors:
Phillip Williams, Thomas Rademacher, Alexander Mark Schobel, Eric Dadey
Abstract: Methods and packages for storing film strips while reducing or eliminating stress cracking during storage, including use of packages having an inner surface made from polymeric materials exhibiting various physical properties and including films and pouches that are annealed.
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film. The invention further relates to edible multi-layer films that dissolve in water. In particular, the edible multi-layer films have a first water-soluble film layer and one or more additional water-soluble film layers in at least partial face-to-face engagement with the first film layer.
Type:
Application
Filed:
March 1, 2016
Publication date:
September 1, 2016
Applicant:
MonoSol Rx, LLC
Inventors:
Richard C. Fuisz, Joseph M. Fuisz, Garry L. Myers
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
Abstract: Methods and packages for storing film strips while reducing or eliminating stress cracking during storage, including use of packages having an inner surface made from polymeric materials exhibiting various physical properties and including films and pouches that are annealed.
Abstract: The invention relates to a process for drying a wet film including the steps of: a) determining a desired loss on drying (LOD) for the wet film; b) determining a relationship between LOD and a rate of temperature rise of the wet film or a rate of change of the rate of temperature rise of the wet film; c) drying a wet film with continuous monitoring of the temperature of the wet film; and d) continuously adjusting one or more drying parameters to maintain the rate of temperature rise of the wet film or the rate of change of the rate of temperature rise of the wet film that produces the desired LOD.