Patent number: 6204259
Abstract: The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula:
wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, R′4, R5, R′5, R6, R′6, R7, R′7, R8, R′8, R9, R′10, R10 and R′10, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, myocardial infarction, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
Type:
Grant
Filed:
January 14, 1993
Date of Patent:
March 20, 2001
Assignee:
Monsanto Company
Inventors:
Dennis P. Riley, Randy H. Weiss, William L. Neumann, Anil S. Modak, Patrick J. Lennon, Karl W. Aston