Abstract: The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective effects of ischemic preconditioning. The compounds are used to reduce injury associated with ischemia and reperfusion of cardiac tissue. Further, the compounds may be used in solutions preserving the viability of an isolated organ.
Type:
Grant
Filed:
December 31, 2003
Date of Patent:
January 1, 2008
Assignee:
Mount Cook Biosciences, Inc.
Inventors:
Kwen-Jen Chang, William Pendergast, Peter J. Gengo, Xin Ma
Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
Type:
Application
Filed:
April 5, 2007
Publication date:
July 26, 2007
Applicant:
MOUNT COOK BIOSCIENCES, INC.
Inventors:
Kwen-Jen Chang, Klim King, Kestutis Biciunas, Robert McNutt, William Pendergast, Shyi-Tai Jan
Abstract: (?)3-((S)-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)(3-thienyl)methyl)phenol and pharmaceutically acceptable esters or salts thereof, in essentially enantiomerically pure form have utility as a cardioprotection agent.