Abstract: The invention provides the art with a powerful diagnostic method of distinguishing relapse-remitting MS subjects from progressive MS subjects, based on the measurement of serum concentrations of N-acetylglucosamine (GlcNAc,), for the first time enabling rapid diagnosis of the progressive form of MS. GlcNAc serum concentration can also be used to assess neurodegenerative status and MS progression in subjects suffering from MS or other neurological conditions. The methods of the invention also allow for the identification of new therapeutics for MS and other neurological conditions and also enables the personalized efficacy assessment of a potential therapy for an MS subject.
Type:
Grant
Filed:
January 29, 2016
Date of Patent:
December 3, 2019
Assignees:
The Regents of the University of California, Charite-Universitatsmedizin Berlin, Mt. Sinai Hospital
Inventors:
Michael Demetriou, Alexander Brandt, Friedmann Paul, James Dennis
Abstract: The invention relates to polypeptides and polynucleotides associated with trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, and uses of same in the prevention, diagnosis and treatment of conditions requiring regulation of trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover. In particular aspects, diagnostic methods are disclosed for evaluating conditions such as preeclampsia utilizing matador polypeptides and polynucleotides encoding same.
Type:
Application
Filed:
February 28, 2013
Publication date:
February 6, 2014
Applicant:
MT. SINAI HOSPITAL
Inventors:
Isabella Caniggia, Martin Post, Nima Soleymanlou, Andrea Jurisicova
Abstract: The invention relates to nucleic acid molecules, kallikrein-like proteins encoded by such nucleic acid molecules; and use of the proteins and nucleic acid molecules.
Abstract: The invention relates to nucleic acid molecules, kallikrein-like proteins encoded by such nucleic acid molecules; and use of the proteins and nucleic acid molecules.
Type:
Grant
Filed:
March 9, 2000
Date of Patent:
April 4, 2006
Assignee:
Mt. Sinai Hospital
Inventors:
George M. Yousef, Eleftherios P. Diamandis