Patents Assigned to Mutual Pharmaceutical Co., Inc.
  • Stable solid dosage forms of amino acids and processes for producing same
    Patent number: 7056951
    Abstract: Pharmaceutical formulations, and processes for making same, comprising an amino acid which is liable to formation of an undesirable lactam, and a stabilizer comprising a volatile alcohol; a non-volatile alcohol; a water immiscible liquid or solid; a liquid with a relatively low dielectric constant; a liquid surface active agent; a solid surface active agent; an antioxidant; a ketone; an aldehyde; a solid polyethylene glycol of high molecular weight; polyvinylpyrrolidone; a derived cellulose; silicon dioxide; or a combination thereof.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: June 6, 2006
    Assignee: Mutual Pharmaceutical Co., Inc.
    Inventor: Spiridon Spireas
  • Stabilization of solid drug formulations
    Patent number: 6979462
    Abstract: Pharmaceutical formulations and dosage forms are provided having improved stability to moisture-induced degradation when compared with conventional dosage forms, especially tablets. The invention features low compression forms of drugs known to be susceptible to moisture-induced degradation together with excipients, preferably in encapsulated forms. In other embodiments, relatively non-volatile oils can be admixed with the drug and/or the excipients to stabilize the formulations toward moisture-induced degradation. Hydrophobic powders are also optionally added to the formulations.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: December 27, 2005
    Assignee: Mutual Pharmaceutical Co., Inc.
    Inventor: Spiridon Spireas
  • Stabilization of solid drug formulations
    Publication number: 20050249801
    Abstract: Pharmaceutical formulations and dosage forms are provided having improved stability to moisture-induced degradation when compared with conventional dosage forms, especially tablets. The invention features low compression forms of drugs known to be susceptible to moisture-induced degradation together with excipients, preferably in encapsulated forms. In other embodiments, relatively non-volatile oils can be admixed with the drug and/or the excipients to stabilize the formulation toward moisture-induced degradation. Hydrophobic powders are also optionally added to the formulations.
    Type: Application
    Filed: July 19, 2005
    Publication date: November 10, 2005
    Applicant: Mutual Pharmaceutical Co., Inc.
    Inventor: Spiridon Spireas
  • Stabilization of solid thyroid drug formulations
    Patent number: 6855333
    Abstract: Pharmaceutical formulations and dosage forms are provided having improved stability to moisture-induced degradation when compared with conventional dosage forms, especially tablets. The invention features low compression forms of thyroid drugs together with excipients, preferably in encapsulated forms. In other embodiments, relatively non-volatile oils can be admixed with the drug and/or the excipients to stabilize the formulation toward moisture-induced degradation. Hydrophobic powders are also optionally added to the formulations.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: February 15, 2005
    Assignee: Mutual Pharmaceutical Co., Inc.
    Inventor: Spiridon Spireas
  • Stable formulations of ACE inhibitors, and methods for preparation thereof
    Patent number: 6764694
    Abstract: The present invention provides stable formulations of ACE inhibitors, especially enalapril maleate, that can be manufactured in a time efficient, cost effective manner. Such formulations can be prepared simply and on a large industrial scale. The present invention also provides methods for the preparation of stable formulations of ACE inhibitors, especially enalapril maleate.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: July 20, 2004
    Assignee: Mutual Pharmaceutical Co., Inc.
    Inventor: Spiridon Spireas
  • Stable formulations of ACE inhibitors, and methods for preparation thereof
    Patent number: 6555551
    Abstract: The present invention provides stable formulations of ACE inhibitors, especially enalapril maleate, that can be manufactured in a time efficient, cost effective manner. Such formulations can be prepared simply and on a large industrial scale. The present invention also provides methods for the preparation of stable formulations of ACE inhibitors, especially enalapril maleate.
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: April 29, 2003
    Assignee: Mutual Pharmaceutical Co., Inc.
    Inventor: Spiridon Spireas