Abstract: The invention provides topical formulations and methods comprising charged bioactive agents complexed with amphipol polymers for dermal and transdermal delivery, optionally further including TJ-modulating peptides.
Abstract: The invention provides topical formulations and methods comprising charged bioactive agents complexed with amphipol polymers for dermal and transdermal delivery, optionally further including TJ-modulating peptides.
Abstract: Improved chemodenervation agents are provided comprising polypeptide ?-neurotoxins having high binding specificity and selectivity for the human muscular ?1 nAChR instead of the human neuronal ?7 nAChR, along with pharmaceutical compositions and methods of use.