Patents Assigned to Naeja Pharmaceutical Inc.
  • Bicyclic compounds and their use as antibacterial agents and ?-lactamase inhibitors
    Patent number: 8877743
    Abstract: A compound of formula (I): wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; and R1 and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: November 4, 2014
    Assignee: Naeja Pharmaceutical Inc.
    Inventors: Samarendra N. Maiti, Dai Nguyen, Jehangir Khan, Rong Ling
  • BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETALACTAMASE INHIBITORS
    Publication number: 20140221341
    Abstract: A compound of formula (I): wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR1 or NR2R3, and R1, R2, R3 and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.
    Type: Application
    Filed: April 15, 2014
    Publication date: August 7, 2014
    Applicant: NAEJA PHARMACEUTICAL INC.
    Inventors: Samarendra N. MAITI, Dai NGUYEN, Jehangir KHAN, Rong LING
  • Bicyclic compounds and their use as antibacterial agents and ?-lactamase inhibitors
    Patent number: 8796257
    Abstract: A compound of formula (I): wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR1 or NR2R3, and R1, R2, R3 and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: August 5, 2014
    Assignee: Naeja Pharmaceutical Inc.
    Inventors: Samarendra N. Maiti, Dai Nguyen, Jehangir Khan, Rong Ling
  • NEW BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETA-LACTAMASE INHIBITORS
    Publication number: 20130225554
    Abstract: A compound of formula (I): wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR1 or NR2R3, and R1, R2, R3 and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.
    Type: Application
    Filed: November 30, 2012
    Publication date: August 29, 2013
    Applicant: NAEJA PHARMACEUTICAL INC.
    Inventor: Naeja Pharmaceutical Inc.
  • NOVEL FUSED BRIDGED BICYCLIC HETEROARYL SUBSTITUTED 6-ALKYLIDENE PENEMS AS POTENT BETA-LACTAMASE INHIBITORS
    Publication number: 20110288063
    Abstract: A compound of formula (I) or formula (Ia) Wherein R1, Ra, R2, X, R3, Y1, Y2, A, B and C are as defined herein. Also, pharmaceutical compositions comprising such compounds and excipients, methods of treating bacterial infections comprising administering such compounds, methods for making such compounds and hydrates of such compounds.
    Type: Application
    Filed: May 19, 2011
    Publication date: November 24, 2011
    Applicant: Naeja Pharmaceutical Inc.
    Inventors: Samarendra N. MAITI, Rong Ling, Judy Yip, Chuanjun Gao, Dai Nguyen, Biswajeet Ganguli, Hong Liang, Jehangir Khan, Andhe V. Narender Reddy
  • Cysteine protease inhibitors
    Patent number: 6635621
    Abstract: This invention relates to derivatives of alpha-amino acid amides, to pharmaceutical compositions containing such compounds, and to their use in medicine as inhibitors of cysteine proteases, particularly the cathepsins. A compound of formula (I) is described or a pharmaceutically acceptable salt, hydrate or solvate thereof. Pharmaceutically acceptable salts of the compounds of this invention include the sodium, potassium, magnesium, calcium, hydrogen chloride, tartaric acid, succinic acid, fumaric acid and p-toluenesulfonic acid salts.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: October 21, 2003
    Assignee: Naeja Pharmaceutical Inc.
    Inventors: Rajeshwar Singh, Nian Zhou, Andhe V. N. Reddy, George Thomas, Qizhu Ding, Jadwiga Kaleta, Ronald George Micetich, Mark Whittaker
  • Substituted azetidin-2-ones as cysteine protease inhibitors
    Patent number: 6569847
    Abstract: This invention relates to substituted azetidin-2-ones and to pharmaceutical compositions containing such compounds. Their use in medicine as inhibitors of cysteine proteases, particularly the cathepsins is also described. The invention includes a compound of formula (I), Y represents —C(O)— or —S(O2)—; R represents an allyl (ie CH2═CHCH2—) group or a radical. R1 represents —OCOR5, —OR5, —SR5, —S(O)R5, or —S(O)2R5; R2 represents a radical. R3 represents —OR5 or R5; or a pharmaceutically acceptable salt, hydrate or solvate thereof.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: May 27, 2003
    Assignee: NAEJA Pharmaceuticals Inc.
    Inventors: Rajeshwar Singh, Andhe V. Narender Reddy, Jadwiga Kaleta, Ronald G. Micetich, Mark Whittaker, Philip Huxley
  • Substituted amino bicyclic-&bgr;-lactam penam and cepham derivatives as cysteine protease inhibitors
    Patent number: 6232305
    Abstract: The present invention provides substituted amino bicyclic-&bgr;-lactam penam derivatives and substituted amino bicyclic-&bgr;-lactam cepham derivatives and their diastereoisomers of formula I, as well as compositions, methods of making, and methods of using, which exhibit excellent cysteine protease inhibitory activity and which may be used for treatment of different diseases such as cancer (including cancer metastasis), osteoporosis, rheumatoid arthritis.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: May 15, 2001
    Assignee: Naeja Pharmaceutical Inc.
    Inventors: Rajeshwar Singh, Nian Zhou, Deqi Guo, Ronald G. Micetich