Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
Type:
Grant
Filed:
January 7, 2015
Date of Patent:
December 29, 2015
Assignee:
Naktar Therapeutics
Inventors:
Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
Abstract: Provided herein are water-soluble polymer conjugates and polymer-based compositions of antimicrobial agents. Also provided are methods for synthesizing and administering such conjugates and compositions.
Abstract: Dispersibility of a respirable powder, administrable by inhalation, is increased by including a pharmaceutically acceptable water-soluble polypeptide.
Type:
Grant
Filed:
August 15, 2000
Date of Patent:
June 24, 2003
Assignee:
Naktar Therapeutics
Inventors:
Mohammad Eljamal, John S. Patton, Linda C. Foster, Robert M. Platz