Abstract: The invention discloses an instant hand-protection antibacterial gel, a method for preparing the same and use of the same, and belongs to the technical field of antibacterial disinfection. The instant hand-protection antibacterial gel of the present invention comprises: hydrolyzed sodium hyaluronate 0.01-0.5%, keratin care agent 0.01%-5%, thickener 0.1-0.5%, emollient 1-10%, pH regulator 0.1-0.5%, ethanol 56-75%, and the balance is water; and an average molecular weight of the hydrolyzed sodium hyaluronate is one or more of 500-20000 Daltons.