Abstract: Particles in a mobile solid phase for chromatographic separation of sample components are disclosed. These particles comprise a core and a coating, wherein said core interacts with at least one analyte and said coating essentially prevents flocculation or aggregation. The core is preferably a polymer and the analyte is preferably detected with a mass analyzer with an angled ionization source.
Abstract: The invention describes a new integrated separation and analysis system for analysis and separation of at least one sample component, comprising a mass sensitive detector (1) with ionization source (2), at least one mobile solid phase (3), at least one sample component (4), one transport system (5) where the mobile solid phase and the sample component are transported, and at least one transport fluid (6). The sample component is separated at the interface between the transport and the mass sensitive detector. Also, a method for analysis and separation of sample components is included, utilizing the mentioned integrated separation and analysis system. According to the method, the mobile solid phase and the sample are separated before the mass analyzer, and the sample components are transported towards the mass analyzer.
Type:
Grant
Filed:
May 30, 2003
Date of Patent:
June 21, 2005
Assignee:
Nanosep AB
Inventors:
Staffan Nilsson, Peter Spégel, Peter Viberg, Leif Schweitz