Abstract: Methods for treating metabolic diseases are described for intranasal delivery of an exenatide, comprising an aqueous mixture of exendin, and a delivery enhancer selected from the group consisting of a solubilizer, a chelator, and a surfactant, and the pharmaceutical formulations used therein.
Type:
Application
Filed:
May 20, 2008
Publication date:
September 25, 2008
Applicant:
NASTECH PHARMACEUTICAL COMPANY INC.
Inventors:
Steven C. Quay, Alexis Kays Leonard, Henry R. Costantino
Abstract: What is described is an aqueous pharmaceutical formulation for intranasal delivery of PTH, consisting essentially of PTH(1-34) and sorbitol; or PTH(1-34), sorbitol, and a surface active agent; or PTH(1-34), sorbitol, and halogenated alkyl alcohol; or PTH(1-34), sorbitol, a surface active agent, and a halogenated alkyl alcohol.
Type:
Application
Filed:
July 6, 2007
Publication date:
May 22, 2008
Applicant:
NASTECH PHARMACEUTICAL COMPANY INC.
Inventors:
Henry R. Costantino, Ching-Yuan Li, Kristin B. Prinn
Abstract: Compositions and methods are provided for intranasal delivery of interferon-? yielding improved pharmacokinetic and pharmacodynamic results. In certain aspects of the invention, the interferon-? is delivered to the intranasal mucosa along with one or more intranasal delivery-enhancing agent(s) to yield substantially increased absorption and/or bioavailability of the interferon-? and/or a substantially decreased time to maximal concentration of interferon-? in a tissue of a subject as compared to controls where the interferon-? is administered to the same intranasal site alone or formulated according to previously disclosed reports. The enhancement of intranasal delivery of interferon-? according to the methods and compositions of the present invention allows for the effective pharmaceutical use of these agents to treat a variety of diseases and conditions in mammalian subjects.
Type:
Application
Filed:
December 10, 2007
Publication date:
May 15, 2008
Applicant:
Nastech Pharmaceutical Company Inc.
Inventors:
Steven Quay, Malini Gupta, Jorge de Meireles, Mohammed Abd El-Shafy
Abstract: Trp cage binding domains polypeptides are disclosed. The Trp cage binding domains have the generic formulae of SEQ ID NO: 2, 7, 10 or 11. They can be efficiently produced and screened using phage display technology.
Type:
Application
Filed:
December 12, 2007
Publication date:
April 24, 2008
Applicant:
NASTECH PHARMACEUTICAL COMPANY INC.
Inventors:
Steven Quay, Douglas Badders, Richard Herman, Michael Houston, Paul Johnson
Abstract: Dicer substrate RNA peptide conjugates comprising a double stranded ribonucleic acid (dsRNA) having a sense strand and an antisense strand, and a peptide, wherein the dicer substrate RNA is conjugated to the peptide, and compositions and methods of use thereof.
Type:
Application
Filed:
August 10, 2007
Publication date:
March 27, 2008
Applicant:
NASTECH PHARMACEUTICAL COMPANY INC.
Inventors:
Steven C. Quay, Paul Hickok Johnson, Michael E. Houston, Roger C. Adami, Renata Fam
Abstract: Trp cage binding domain polypeptides are disclosed. The Trp cage binding domains have the generic formulas of SEQ ID NO: 2, 7, 10 or 11. They can be efficiently produced and screened using phage display technology.
Type:
Grant
Filed:
October 29, 2004
Date of Patent:
February 12, 2008
Assignee:
Nastech Pharmaceutical Company Inc.
Inventors:
Steven C. Quay, Douglas L. Badders, Richard E. Herman, Michael E. Houston, Jr., Paul Hickok Johnson
Abstract: What is described is a means for creating bimodal particle size distribution that targets both nasal cavity and pulmonary regions for drug delivery.
Type:
Application
Filed:
July 6, 2007
Publication date:
February 7, 2008
Applicant:
NASTECH PHARMACEUTICAL COMPANY INC.
Inventors:
Henry R. Costantino, Roger C. Adami, Connie Sau-Kuen Kwok
Abstract: Pharmaceutical compositions and methods of use of a composition containing a double-stranded RNA (dsRNA), cationic lipids, non-cationic lipids, and lipophilic delivery-enhancing compounds.
Abstract: A composition of an interfering RNA comprising a double-stranded RNA (dsRNA) molecule having a double-stranded region of from about 15 to about 40 base pairs, a peptide having a hydrophobic region and a cationic region, and a non-cationic phospholipid, and uses thereof.
Type:
Application
Filed:
May 2, 2007
Publication date:
December 6, 2007
Applicant:
NASTECH PHARMACEUTICAL COMPANY INC.
Inventors:
Kunyuan Cui, Dong Liang, David S. Sweedler
Abstract: What is described is a stable double stranded (ds) nucleic acid molecule composition, comprising a dsRNA molecule complexed with an organic cation.
Type:
Application
Filed:
February 16, 2007
Publication date:
November 29, 2007
Applicant:
NASTECH PHARMACEUTICAL COMPANY INC.
Inventors:
David S. Sweedler, Roger C. Adami, Henry R. Costantino, Steven C. Quay
Abstract: What is described is a composition for delivery of a RNA molecule to a cell, comprising: a double stranded RNA (dsRNA) molecule of about 15 to about 40 base pairs; and a polynucleotide delivery-enhancing peptide, comprising a region of alternating lysine and histidine residues, or of alternating D and L forms of arginine.
Type:
Application
Filed:
February 16, 2007
Publication date:
November 29, 2007
Applicant:
NASTECH PHARMACEUTICAL COMPANY INC.
Inventors:
Lishan Chen, Michael E. Houston, Roger C. Adami, James Anthony McSwiggen, Sasha J. Mayer, Steven C. Quay
Abstract: What is described is a composition for delivery of a RNA molecule to a cell, comprising: a double stranded RNA (dsRNA) molecule of about 15 to about 40 base pairs; and a cationic polymer peptide comprising at least two cysteine residues and at least one tryptophan residues with one or more repeats consisting of between about five to about 20 positively charged residues, a method for producing such composition, a method of using such composition to deliver dsRNA to a cell, and a method of using such composition to inhibit expression of a target gene.
Type:
Application
Filed:
May 18, 2007
Publication date:
November 22, 2007
Applicants:
NASTECH PHARMACEUTICAL COMPANY INC., UNIVERSITY OF IOWA RESEARCH FOUNDATION
Abstract: Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.
Type:
Application
Filed:
May 4, 2007
Publication date:
October 18, 2007
Applicant:
NASTECH PHARMACEUTICAL COMPANY INC.
Inventors:
Steven Quay, Henry Costantino, Mary Kleppe, Ching-Yuan Li
Abstract: What is described is an aqueous Y2 receptor-binding peptide formulation for enhanced intranasal delivery of a Y2 receptor-binding peptide, comprising said Y2 receptor-binding peptide, a buffer salt, and having a pH between about 3.0 and about 6.0, wherein said buffer salt comprises a net single ionogenic moiety with a pKa within two pH units of the pH of the formulation.
Type:
Application
Filed:
December 19, 2006
Publication date:
October 4, 2007
Applicant:
Nastech Pharmaceutical Company Inc.
Inventors:
Henry Costantino, Mary Kleppe, Annemarie Cohen, Anthony Sileno
Abstract: Double stranded siRNA molecules for combating a respiratory virus, wherein the strands of an siRNA molecule may be from about 15 to about 60 nucleotides, and uses thereof. One strand of an siRNA molecule can be a nucleic acid sequence identical to a conserved site, or a variant thereof, within the nucleic acid sequence of the respiratory virus.
Abstract: A formulation for intranasal delivery of a neuroprotective peptide, comprising an aqueous mixture of a peptide having the sequence NAPVSIPQ or a pharmaceutically acceptable salt thereof, a solubilizing agent, a chelator, and a surface active agent. The formulation can contain a peptide salt or mucosal delivery-enhancing agent which increases the amount of neuroprotective peptide reaching the therapeutic target.
Abstract: A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1.
Type:
Grant
Filed:
February 26, 2004
Date of Patent:
June 12, 2007
Assignee:
Nastech Pharmaceutical Company Inc.
Inventors:
Steven C. Quay, Peter C. Aprile, Zenaida O. Go, Anthony P. Sileno
Abstract: Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
Type:
Grant
Filed:
February 17, 2004
Date of Patent:
June 12, 2007
Assignee:
Nastech Pharmaceutical Company Inc.
Inventors:
Steven C. Quay, Gordon Brandt, Mary S. Kleppe, Conor J. MacEvilly
Abstract: Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
Type:
Grant
Filed:
December 23, 2003
Date of Patent:
March 6, 2007
Assignee:
Nastech Pharmaceutical Company Inc.
Inventors:
Steven C. Quay, Gordon Brandt, Mary S. Kleppe, Conor J. MacEvilly
Abstract: Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.