Patents Assigned to National Biomedical Research Foundation
  • Publication number: 20190252050
    Abstract: This invention concerns an integrated method for providing individuals with current assessments of genetic risk based on genetic tests and genomic research. While existing genetic tests can provide an estimate of genetic risk for many common diseases, genomic research is expected to provide a large number of new genetic test that will enable more definitive assessments of an individual's risk of disease. The invention provides an integrated method and systems for providing individuals with a current assessment of their genetic risk based on such advances. This method has utility in enabling individuals and healthcare professions to use genetic tests in important healthcare and lifestyle decisions.
    Type: Application
    Filed: September 13, 2018
    Publication date: August 15, 2019
    Applicant: National Biomedical Research Foundation
    Inventor: Fred David Ledley
  • Publication number: 20170076037
    Abstract: This invention describes a method and site for providing genetic testing using the Internet which enables individuals to access genetic testing as well as methods that ensure privacy in the selection of genetic tests, payment, performance of tests, delivery of results, interpretation of results, and genetic counseling. These methods will increase the utilization of genetic testing by individuals.
    Type: Application
    Filed: August 19, 2016
    Publication date: March 16, 2017
    Applicant: National BioMedical Research Foundation
    Inventor: Fred D. Ledley
  • Patent number: 8483966
    Abstract: This invention describes a method and site for providing genetic testing using the Internet which enables individuals to access genetic testing as well as methods that ensure privacy in the selection of genetic tests, payment, performance of tests, delivery of results, interpretation of results, and genetic counseling. These methods will increase the utilization of genetic testing by individuals.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: July 9, 2013
    Assignee: National Biomedical Research Foundation
    Inventor: Fred David Ledley
  • Patent number: 8438042
    Abstract: This invention provides an instrument for obtaining consent for a genetic test that comprises three or more integrated elements including an information element for conveying information to an individual concerning a genetic test, and instruction element for use by a practitioner in instructing individuals on the genetic test and use of the instrument, a collection element for collecting an individual's medical and family history, a assessment element for assessing the individual's retention and understanding of information concerning a genetic test, a certification element for certifying the individual's consent to said tests, as well as housekeeping elements useful for recording a medical record, labeling a sample, and billing. Also provided is a method for obtaining informed consent for a genetic test using an integrated instrument. The instruments and methods disclosed have utility in obtaining informed consent for genetic tests.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: May 7, 2013
    Assignee: National Biomedical Research Foundation
    Inventor: Fred David Ledley
  • Patent number: 5335683
    Abstract: A non-slip support shoe for attachment to the end of any crutch or other walking aid comprises an attachment cylinder for attaching the shoe to the bottom of the crutch or walking aid; a pair of strip leaf springs, at least one of which is connected to the attachment cylinder; and a rubber sole provided on the bottom surface of a lower one of the strip leaf springs. In operation, when the maximum weight of a body is exerted on the crutch or walking aid, the strip leaf springs change configuration (i.e., flatten) so that the entire sole located on the lower strip leaf spring contacts the ground, thereby preventing slippage during use of the crutch or walking aid. Once the maximum weight of the body is removed, the strip leaf springs return to their original configuration so as not to interfere with the angled forward and backward positions of the crutch during use.
    Type: Grant
    Filed: June 3, 1993
    Date of Patent: August 9, 1994
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: 5296846
    Abstract: A cursor control device for use with a three-dimensional stereoscopic image display system comprises a housing defining a volume corresponding to a displayed three-dimensional volume, and a joystick operable by the user for moving and positioning a cursor in the displayed three-dimensional volume. The joystick has a knob which is movable within the volume defined by the housing so as to designate desired positioning and movement of the cursor within the displayed three-dimensional volume. There is, at any given time, both positional and movement congruency between the position and movement of the knob and position and movement, respectively, of the cursor.
    Type: Grant
    Filed: October 5, 1992
    Date of Patent: March 22, 1994
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: 4821728
    Abstract: A three-dimensional imaging system for obtaining a three-dimensional image of an object being scanned ultrasonically comprises a source arrangement for sequentially transmitting ultrasonic energy toward the object in successive directions in a first scanning plane, followed by sequential transmission of ultrasonic energy toward the object in successive directions in successive scanning planes parallel to the first scanning plane, a detector arrangement for receiving reflected energy and converting the reflected energy to electrical signals, and a processor for processing the electrical signals to develop reconstructed image data of the object, the reconstructed image data comprising forward projections of the object into a left image plane and a right image plane to form left and right images, respectively, the left and right images forming a stereo pair for composite display by a display unit.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: April 18, 1989
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: 4817119
    Abstract: An array of radiation detectors is rotated about one or more sources of fan-shaped substantially planar radiation beams which are, in turn, rotated in the opposite direction about a three-dimensional body such that substantially parallel paths are defined between given individual detectors of the array and the radiation sources during the course of their oppositely directed movements. Radiation absorption measurements are taken along thusly defined plural intersecting sets of substantially parallel paths within a desired cross-section of the three-dimensional body to provide data for use in computing and displaying a constructed visual image of structures having different radiation absorption coefficients within the cross-section.
    Type: Grant
    Filed: August 25, 1977
    Date of Patent: March 28, 1989
    Assignee: National Biomedical Research Foundation
    Inventors: Robert S. Ledley, James B. Wilson
  • Patent number: 4798210
    Abstract: A three-dimensional imaging system for obtaining a three-dimensional image of an object being scanned ultrasonically comprises a source arrangement for sequentially transmitting ultrasonic energy toward the object in successive directions in a first scanning plane, followed by sequential transmission of ultrasonic energy toward the object in successive directions in successive scanning planes, a detector arrangement for receiving reflected energy and converting the reflected energy to electrical signals, and a processor for processing the electrical signals to develop reconstructed image data of the object, the reconstructed image data comprising forward projections of the object into a left image plane and a right image plane to form left and right images, respectively, the left and right images forming a stereo pair for composite display by a display unit. In one embodiment, each successive scanning plane is parallel to the first scanning plane.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: January 17, 1989
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: 4769698
    Abstract: A system and method for interactively displaying magnified images of an object having different respective magnifications is disclosed. The system comprises a microscope stage for holding the object, an optical arrangement for magnifying an image of the object in accordance with different respective magnifications so as to produce first and second optical outputs in corresponding first and second optical paths with different respective magnifications in each path, first and second cameras disposed in the first and second paths, and display units for displaying the first and second images of the object magnified in accordance with the different respective magnifications.
    Type: Grant
    Filed: March 16, 1987
    Date of Patent: September 6, 1988
    Assignee: National Biomedical Research Foundation
    Inventors: Robert S. Ledley, Thomas J. Golab
  • Patent number: 4724485
    Abstract: Television (TV) scanning with improved resolution is obtained by implementation into a conventional TV scanning arrangement of a vertical drive signal modifying circuit which modifies vertical drive signals prior to their being provided as an input to the conventional TV scanning arrangement. Processing of the vertical drive signals results in the generation of various time delay signals which, when logically combined in accordance with the present invention, result in the generation of modified vertical drive signals. As a result of application of the modified vertical drive signals to the conventional TV scanner arrangement, the number of fields making up the conventional interlace pattern is multiplied by an integral factor greater than one.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: February 9, 1988
    Assignee: National Biomedical Research Foundation
    Inventors: Thomas J. Golab, Robert S. Ledley
  • Patent number: 4673973
    Abstract: A split-image, multi-power microscopic image display system and method wherein the image of an object positioned on a slide is split into two optical paths, and is magnified to a varying degree in each optical path, the resulting respective magnifications being displayed on respective monitor devices. The initial optical path includes an objective and a splitter; the path of lower magnification includes a converging lens, diverging lens, reduction lens, bending prism, TV camera and TV monitor; the path of higher magnification includes a trinocular microscope head, TV camera, and TV monitor.
    Type: Grant
    Filed: February 4, 1985
    Date of Patent: June 16, 1987
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: 4656594
    Abstract: An operator-interactive automated chromosome analysis system is employed by an operator to locate and identify acceptable metaphase spreads, form a karyotype by rearranging the identified metaphase spreads in accordance with a predetermined arrangement of the twenty-three pairs of chromosomes naturally occurring in human beings, and display the karyotype on a display or a hardcopy printout, or both.
    Type: Grant
    Filed: May 6, 1985
    Date of Patent: April 7, 1987
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: 4651200
    Abstract: A split-image, multi-power microscopic image display system and method wherein the image of an object positioned on a slide is split into two optical paths, and is magnified to a varying degree in each optical path, the resulting respectively magnified images being displayed on respective monitor devices. The initial optical path includes an objective and a splitter; the paths of lower magnification and higher magnification each include a TV camera and a TV monitor, and may include various optical elements in accordance with the four disclosed embodiments.
    Type: Grant
    Filed: October 4, 1985
    Date of Patent: March 17, 1987
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: 4563173
    Abstract: A pump-actuated sequencing valve for sequentially administering, to a patient, two fluids contained in separate respective reservoirs, wherein the fluid is pumped from a first one of the two reservoirs by means of a pump associated therewith. The valve comprises a first portion connected to the first reservoir, a second portion connected to the second reservoir, and a third portion connected between the first and second portions, on the one hand, and the patient, on the other hand. The second portion includes a ball valve which is pressure-responsive to operation of the pump for blocking flow of fluid to and from the second reservoir, thus blocking both forward flow from the second reservoir and backflow from the sequencing valve toward the second reservoir.
    Type: Grant
    Filed: April 19, 1983
    Date of Patent: January 7, 1986
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: 4229797
    Abstract: A method and system for whole picture image processing achieves automatic texture and color analysis in a rapid and economical manner. The method involves the generation of texture parameters as a result of processing image data for a whole picture at a time. The system comprises a plurality of image memories for storing digital image data, and a high speed video processor which obtains whole picture image data and processes same so as to analyze such whole picture image data at high speeds. The system also includes a video crossbar switch, master and slave timing control units, and a transformation unit associated with each image memory.
    Type: Grant
    Filed: September 6, 1978
    Date of Patent: October 21, 1980
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: RE33883
    Abstract: A split-image, multi-power microscopic image display system and method wherein the image of an object positioned on a slide is split into two optical paths, and is magnified to a varying degree in each optical path, the resulting respective magnifications being displayed on respective monitor devices. The initial optical path includes an objective and a splitter; the path of lower magnification includes a converging lens, diverging lens, reduction lens, bending prism, TV camera and TV monitor; the path of higher magnification includes a trinocular microscope head, TV camera, and TV monitor.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: April 14, 1992
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: RE34566
    Abstract: A three-dimensional imaging system for obtaining a three-dimensional image of an object being scanned ultrasonically comprises a source arrangement for sequentially transmitting ultrasonic energy toward the object in successive directions in a first scanning plane, followed by sequential transmission of ultrasonic energy toward the object in successive directions in successive scanning planes parallel to the first scanning plane, a detector arrangement for receiving reflected energy and converting the reflected energy to electrical signals, and a processor for processing the electrical signals to develop reconstructed image data of the object, the reconstructed image data comprising forward projections of the object into a left image plane and a right image plane to form left and right images, respectively, the left and right images forming a stereo pair for composite display by a display unit.
    Type: Grant
    Filed: November 1, 1989
    Date of Patent: March 22, 1994
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley
  • Patent number: RE34622
    Abstract: A split-image, multi-power microscopic image display system and method wherein the image of an object positioned on a slide is split into two optical paths, and is magnified to a varying degree in each optical path, the resulting respectively magnified images being displayed on respective monitor devices. The initial optical path includes an objective and a splitter; the paths of lower magnification and higher magnification each include a TV camera and a TV monitor, and may include various optical elements in accordance with the four disclosed embodiments.
    Type: Grant
    Filed: March 16, 1989
    Date of Patent: May 31, 1994
    Assignee: National Biomedical Research Foundation
    Inventor: Robert S. Ledley