Patents Assigned to National Cancer Center
  • Patent number: 11905565
    Abstract: This invention provides a kit or device for detection of prostate cancer and a method for detecting prostate cancer. This invention provides a kit or device for detection of prostate cancer comprising a nucleic acid capable of specifically binding to an miRNA in a sample from a subject or a complementary strand thereof and a method for detecting prostate cancer comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: November 17, 2022
    Date of Patent: February 20, 2024
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Makiko Yoshimoto, Hiroko Sudo, Atsuko Miyano, Satoko Kozono, Takahiro Ochiya, Hiroyuki Fujimoto, Fumihiko Urabe, Juntaro Matsuzaki
  • Publication number: 20240052429
    Abstract: It is intended to provide a kit or device for the detection of liver cancer and a method for detecting liver cancer. The present invention relates to a kit or device for the detection of liver cancer, comprising a nucleic acid capable of specifically binding to miRNA in a sample of a subject, and a method for detecting liver cancer, comprising measuring the miRNA in vitro.
    Type: Application
    Filed: October 20, 2023
    Publication date: February 15, 2024
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi KONDOU, Hitoshi NOBUMASA, Satoko KOZONO, Hiroko SUDO, Junpei KAWAUCHI, Atsushi OCHIAI, Motohiro KOJIMA
  • Patent number: 11897954
    Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: February 13, 2024
    Assignees: Astellas Pharma Inc., National Cancer Center
    Inventors: Yoshiyuki Tenda, Masatoshi Yuri, Daisuke Yamajuku, Takeshi Tsutsumi, Yuko Kusuzaki, Hiroki Sasaki, Fumiko Chiwaki, Masayuki Komatsu
  • Patent number: 11901043
    Abstract: Disclosed is a sequence analysis method for analyzing nucleic acid sequence, the sequence analysis method including: obtaining a plurality of read sequences read from the nucleic acid sequence; and determining each nucleic acid sequence by aligning each read sequence with reference to a single reference sequence, wherein the reference sequence includes at least a first rearrangement sequence and a second rearrangement sequence that is different from the first rearrangement sequence.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: February 13, 2024
    Assignees: National Cancer Center, Mitsui Knowledge Industry Co., Ltd., Sysmex Corporation
    Inventors: Mamoru Kato, Hideya Kuwabara, Tomohiro Sakuma, Fumio Inoue, Kenichiro Suzuki
  • Publication number: 20240027455
    Abstract: Provided is a method of assisting breast cancer diagnosis, comprising: a measuring step for measuring an amount of laminin 5 or laminin ?3 in a specimen; and an information-providing step for providing information for breast cancer diagnosis based on the amount of laminin 5 or laminin ?3 thus measured. Provided is a test kit for breast cancer comprising an anti-laminin 5 antibody or an anti-laminin ?3 antibody.
    Type: Application
    Filed: December 6, 2021
    Publication date: January 25, 2024
    Applicants: NATIONAL CANCER CENTER, SHIMADZU CORPORATION, DAI NIPPON TORYO CO., LTD.
    Inventors: Kenji TAMURA, Kazuki SUDO, Takahisa MATSUDA, Taiki YAMAJI, Koji OKAMOTO, Makoto WATANABE, Hirotaka FUJIMOTO, Taka-Aki SATO, Yuta MIYAZAWA
  • Patent number: 11880003
    Abstract: Disclosed is an apparatus for measuring the distribution of radiation dose emitted from a brachytherapy insertion tool, the apparatus including a housing having defined therein a measurement space in which the brachytherapy insertion tool is located, a fluorescent member disposed at the housing, the fluorescent member being configured to react with radiation emitted to the measurement space and to emit light, a camera disposed in the housing, and a cover coupled to one surface of the housing, the cover being configured to cover the fluorescent member. The portion of the fluorescent member to which radiation from a radiation source of the brachytherapy insertion tool is applied reacts with the radiation and generates light, brightness of the light varies depending on distribution of the radiation, and the position at which the light is bright is calculated to measure the direction in which the brachytherapy insertion tool has no shielding.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: January 23, 2024
    Assignees: THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC), CHUNGNAM NATIONAL UNIVERSITY HOSPITAL, NATIONAL CANCER CENTER, KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Ui-Jung Hwang, Young Kyung Lim, Sang Hyoun Choi, Youngmoon Goh, Ki Hwan Kim
  • Publication number: 20240018224
    Abstract: An object of the present invention is to provide: an anti-GPC3 antibody that recognizes an epitope different from that for existing antibodies (e.g., GC33 and GC199) and can specifically bind, even in the form of single chain antibody, to GPC3 localized on a cell membrane; CAR comprising the anti-GPC3 single chain antibody; an immunocompetent cell expressing the CAR; a gene of the anti-GPC3 antibody or a gene of the CAR; a vector comprising the anti-GPC3 antibody gene or the CAR gene; a host cell in which the vector has been introduced; a method for specifically detecting GPC3; and a kit for specifically detecting GPC3. An antibody comprising particular heavy chain CDR1 to CDR3 and particular light chain CDR1 to CDR3 defined in claim 1, and specifically binding to a human-derived GPC3 polypeptide specifically binds to GPC3 localized on a cell membrane. CAR-immunocompetent cells prepared on the basis of CAR comprising such single chain antibody are useful for cancer immunotherapy.
    Type: Application
    Filed: June 15, 2023
    Publication date: January 18, 2024
    Applicants: Yamaguchi University, National Cancer Center, Noile-Immune Biotech, Inc.
    Inventors: Koji TAMADA, Yukimi SAKODA, Tetsuya NAKATSURA, Keigo SAITO
  • Publication number: 20240011104
    Abstract: This invention provides a kit or a device for the detection of pancreatic cancer, comprising a nucleic acid(s) capable of specifically binding to a miRNA(s) in a sample from a subject, and a method for detecting pancreatic cancer, comprising measuring the miRNA(s) in vitro.
    Type: Application
    Filed: September 7, 2023
    Publication date: January 11, 2024
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Junpei KAWAUCHI, Hitoshi NOBUMASA, Satoko KOZONO, Satoshi KONDOU, Hiroko SUDO, Atsushi OCHIAI, Motohiro KOJIMA
  • Patent number: 11869193
    Abstract: A method includes: inputting an image of a target to each of a first model for estimating a region of an annular face of the target, a second model for estimating a region in an outer circumference of the annular face and a third model for estimating a region in an inner circumference of the annular face, and outputting a region image, as an estimated region of the annular face, the region image being obtained by synthesizing first, second, and third elements. The first element is a region outputted as a result of the first model for calculating a sum set in the synthesizing, the second element is a region outputted as a result of the second model for calculating a sum set in the synthesizing, and the third element is a region outputted as a result of the third model for calculating a difference set in the synthesizing.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: January 9, 2024
    Assignees: Fujitsu Limited, RIKEN, NATIONAL CANCER CENTER
    Inventors: Akira Sakai, Masaaki Komatsu, Kanto Shozu
  • Patent number: 11859256
    Abstract: Disclosed is a kit or a device for the detection of stomach cancer and a method for detecting stomach cancer, and provides a kit or a device for the detection of stomach cancer, including a nucleic acid(s) capable of specifically binding to a miRNA(s) in a sample from a subject, and a method for detecting stomach cancer, including measuring the miRNA(s) in vitro.
    Type: Grant
    Filed: September 20, 2022
    Date of Patent: January 2, 2024
    Assignees: TORAY INDUSTRIES, LTD., NATIONAL CANCER CENTER
    Inventors: Satoko Kozono, Hitoshi Nobumasa, Satoshi Kondou, Hiroko Sudo, Junpei Kawauchi, Atsushi Ochiai, Motohiro Kojima
  • Patent number: 11859255
    Abstract: It is intended to provide a kit or a device for the detection of breast cancer and a method for detecting breast cancer. The present invention provides a kit or a device for the detection of breast cancer, comprising nucleic acid(s) capable of specifically binding to a miRNA in a sample of a subject, and a method for detecting breast cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: September 14, 2022
    Date of Patent: January 2, 2024
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi Kondou, Hitoshi Nobumasa, Satoko Kozono, Hiroko Sudo, Junpei Kawauchi, Takahiro Ochiya, Nobuyoshi Kosaka, Makiko Ono, Kenji Tamura
  • Publication number: 20230419517
    Abstract: A display processing unit causes a display device to display an endoscopic image of a living tissue in a somatic cavity captured by an endoscope. An operation reception unit receives a user operation that is performed so as to set an area of interest in the endoscopic image. An area-of-interest setting unit sets the area of interest in the endoscopic image based on the user operation. A three-dimensional information acquisition unit acquires three-dimensional shape information of the living tissue captured by the endoscope. A virtual surface derivation unit derives three-dimensional shape information of a virtual surface in the area of interest from three-dimensional shape information of an area different from the area of interest. A size information identification unit identifies information concerning a size of the virtual surface from the three-dimensional shape information of the virtual surface.
    Type: Application
    Filed: September 11, 2023
    Publication date: December 28, 2023
    Applicants: OLYMPUS CORPORATION, NATIONAL CANCER CENTER
    Inventors: Tatsuya NAKAMURA, Daichi WATANABE, Kazunari HANANO, Keigo MATSUO, Taku SAKAMOTO, Ichiro ODA
  • Publication number: 20230390344
    Abstract: A method for enhancing immunity, including administering a composition containing a Prevotella stercorea strain or a culture solution thereof to a subject in need thereof. A method for increasing an anticancer effect, including administering a composition containing a Prevotella stercorea strain or a culture solution thereof to a subject in need thereof. A method for treating cancer, including administering a composition containing a Prevotella stercorea strain or a culture solution thereof, and an immune checkpoint inhibitor to a subject in need thereof.
    Type: Application
    Filed: October 27, 2021
    Publication date: December 7, 2023
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION, NATIONAL CANCER CENTER
    Inventor: Sook Ryun PARK
  • Patent number: 11827941
    Abstract: It is intended to provide a kit or device for the detection of liver cancer and a method for detecting liver cancer. The present invention relates to a kit or device for the detection of liver cancer, comprising a nucleic acid capable of specifically binding to miRNA in a sample of a subject, and a method for detecting liver cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: October 21, 2022
    Date of Patent: November 28, 2023
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi Kondou, Hitoshi Nobumasa, Satoko Kozono, Hiroko Sudo, Junpei Kawauchi, Atsushi Ochiai, Motohiro Kojima
  • Publication number: 20230371921
    Abstract: The present invention relates to a method for analyzing ultrasound data obtained by passing through multiple layers, comprising the steps of: reducing noise in the ultrasound data; identifying an interface between layers by identifying the peak of the ultrasound data after removal of the noise; and differentiating each layer by identifying an attenuation coefficient of the ultrasound data after removal of the noise.
    Type: Application
    Filed: October 19, 2021
    Publication date: November 23, 2023
    Applicant: NATIONAL CANCER CENTER
    Inventors: Dae Woo PARK, Dong Chan PARK
  • Patent number: 11819710
    Abstract: The present invention relates to a method, a device, and a program for calculating a brachytherapy plan, and a brachytherapy apparatus. The method comprises: a step in which a computer obtains the number of radiation irradiation spots on the basis of radiation irradiation information (a radiation irradiation spot number obtaining step (S200)); a step in which the computer obtains target area information from a body model of a patient generated on the basis of medical image data of the patient (a target area information obtaining step (S400)); and a therapy plan calculating step (S600) in which the computer calculates, on the basis of the radiation irradiation information and the target area information, the radiation irradiation spots to which radiation is irradiated and the time length of irradiation to each radiation irradiation spot.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: November 21, 2023
    Assignees: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION, NATIONAL CANCER CENTER, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Ho Jin Kim, Jung Won Kwak, Byung Chul Cho, Sang Wook Lee, Chi Young Jeong, Young Kyung Lim, Ui Jung Hwang, Sang Hyoun Choi
  • Publication number: 20230365988
    Abstract: The present invention relates to a mouse model for bio-imaging of inflammation, a preparation method therefor and a use thereof. Particularly, by using the mouse model, which is made by crossing a mouse model with a mouse expressing Cre recombinase specifically in certain tissues and cells, certain tissue- and cell-specific inflammatory signals desired by a researcher can be evaluated in vitro and the progress of inflammatory changes over time without the autopsy of living animals can be identified, and thus the present invention can be used throughout the field of life science research including experimental animal science, molecular biology and the like, and can also be used as a model for efficacy evaluation of anti-inflammatory candidates in the industrial area such as new drug or health functional food development and the like.
    Type: Application
    Filed: November 11, 2021
    Publication date: November 16, 2023
    Applicants: KOREA MOUSE PHENOTYPING CENTER, NATIONAL CANCER CENTER, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Je Kyung Seong, Ho Lee, Seung Hyun Oh, Min Woo Kim, Yoon Jeon
  • Publication number: 20230364163
    Abstract: To provide a pharmaceutical composition capable of enhancing the effect of an immune checkpoint inhibitor against tumor or cancer in a subject. Provided is a pharmaceutical composition that comprises bacterial cells, a culture supernatant, a metabolite, and/or a bacterial cell extract of Ruminococcaceae enterobacterium, and is administered in combination with an immune checkpoint inhibitor.
    Type: Application
    Filed: September 29, 2021
    Publication date: November 16, 2023
    Applicants: NATIONAL CANCER CENTER, RIKEN
    Inventors: Hiroyoshi Nishikawa, Shota Fukuoka, Yoshimi Benno, Yuko Shigeno
  • Patent number: 11813332
    Abstract: The present invention relates to a conjugate for photodynamic diagnosis or treatment in which a peptide binds with a photosensitizer via an intracellularly degradable linkage, and to a composition for photodynamic diagnosis or treatment including the same.
    Type: Grant
    Filed: July 4, 2017
    Date of Patent: November 14, 2023
    Assignee: NATIONAL CANCER CENTER
    Inventors: Yong-Doo Choi, Ji-Su Kim
  • Publication number: 20230346835
    Abstract: An antibody specifically binding to BCMA (B-cell maturation antigen) or fragment thereof, including: a heavy chain variable region including a CDR1 region represented by the amino acid sequence of SEQ ID NO: 1, a CDR2 region represented by the amino acid sequence of SEQ ID NO: 2, and a CDR3 region represented by the amino acid sequence of SEQ ID NO: 3; and a light chain variable region including a CDR1 region represented by the amino acid sequence of SEQ ID NO: 4, a CDR2 region represented by the amino acid sequence of SEQ ID NO: 5, and a CDR3 region represented by the amino acid sequence of SEQ ID NO: 6.
    Type: Application
    Filed: May 28, 2021
    Publication date: November 2, 2023
    Applicants: NATIONAL CANCER CENTER, PROTANBIO INC.
    Inventors: Sangjin LEE, Hyeonseok EOM, Eunjung PARK, Bumkyu CHOI, Soyoun RO, Seongwon HONG, Chungyong HAN, Jeyoel CHO, Hyejin SUNG, Siyoung CHOI