Patents Assigned to National Institute for Pharmaceutical Research
  • PYRROLO-AROMATIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
    Publication number: 20200062749
    Abstract: The present invention relates to pyrrolo-aromatic heterocyclic compounds, a preparation method therefor and medical use thereof. Particularly, the present invention relates to a compound represented by formula I, a preparation method therefor, a pharmaceutical composition comprising the compound, and use of the compound as a BTK kinase inhibitor. The compound and the pharmaceutical composition comprising same can be used for the treating diseases associated with BTK kinase activity, such as inflammations, autoimmune disorders, and cancers. The definition of each substituent in formula I is the same as that in the description.
    Type: Application
    Filed: December 26, 2017
    Publication date: February 27, 2020
    Applicant: The National Institutes of Pharmaceutical Research and Development (NIP)
    Inventors: Huijun YIN, Xu YAN, Libin ZONG, Weixue TIAN, Li ZHENG, Haoshuai DOU, Yan YANG
  • Phytodrug for management of peptic ulcer and methods of preparing and using same
    Patent number: 6365201
    Abstract: A phytochemical composition for management of peptic ulcer conditions in humans is provided. The composition is a hot water extract of powdered Indigofera arrecta plant leaves. The extract may be prepared by contacting the powdered leaves with hot water for a period of time, filtering the extraction mixture, concentrating the filtrate in vacuo and freeze drying the concentrated filtrate. The extract is admixed with magnesium carbonate, dried maize starch, talc and magnesium stearate to form a homogenous mass which is filled into capsules. The capsules are ingested orally to provide an analgesic effect. Also described are methods for making the extract and the methodology for using the extract.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: April 2, 2002
    Assignee: National Institute for Pharmaceutical Research and Development
    Inventors: Charles O. N. Wambebe, Shingu K. Gamaniel, Peter Akah, Dogara S. Fumen, Hafsatu Shittu
  • Phytodrug for management of peptic ulcer and methods of preparing and using same
    Patent number: 6086882
    Abstract: A phytochemical composition for management of peptic ulcer conditions in humans is provided. The composition is a hot water extract of powdered Indigofera arrecta plant leaves. The extract may be prepared by contacting the powdered leaves with hot water for a period of time, filtering the extraction mixture, concentrating the filtrate in vacuo and freeze drying the concentrated filtrate. The extract is admixed with magnesium carbonate, dried maize starch, talc and magnesium stearate to form a homogenous mass which is filled into capsules. The capsules are ingested orally to provide an analgesic effect. Also described are methods for making the extract and the methodology for using the extract.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: July 11, 2000
    Assignee: National Institute for Pharmaceutical Research
    Inventors: Charles O. N. Wambebe, Shingu K. Gamaniel, Peter Akah, Dogara S. Fumen, Hafsatu Shittu
  • Phytodrug for management of peptic ulcer and methods of preparing and using same
    Patent number: 6083509
    Abstract: A phytochemical composition for management of peptic ulcer conditions in humans is provided. The composition is a hot water extract of powdered Indigofera arrecta plant leaves. The extract may be prepared by contacting the powdered leaves with hot water for a period of time, filtering the extraction mixture, concentrating the filtrate in vacuo and freeze drying the concentrated filtrate. The extract is admixed with magnesium carbonate, dried maize starch, talc and magnesium stearate to form a homogenous mass which is filled into capsules. The capsules are ingested orally to provide an analgesic effect. Also described are methods for making the extract and the methodology for using the extract.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: July 4, 2000
    Assignee: National Institute for Pharmaceutical Research and Development
    Inventors: Charles O. N. Wambebe, Shingu K. Gamaniel, Peter Akah, Dogara S. Fumen, Hafsatu Shittu
  • Phytodrug for treating skin fungal infections and methods of preparing and using same
    Patent number: 5840310
    Abstract: A phytochemical composition for treating skin fungal infections is provided. The composition is an organic solvent extract of dried, coarsely ground Mitra villosus plant leaves. The extract may be prepared using a hot soxhlet extraction process using hexane as the extraction solvent. The extract is admixed with an excipient base to form an ointment and the ointment is applied topically to areas of skin which are infected with fungal infection. Also described are methods for making the extract and methods for using the extract.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: November 24, 1998
    Assignee: National Institute For Pharmaceutical Research and Development
    Inventors: Charles O. N. Wambebe, Nkechi M. Enwerem, Ibrahim Kolo, Shingu K. Gamaniel
  • Piper guineense, pterocarpus osun, eugenia caryophyllata, and sorghum bicolor extracts for treating sickle cell disease
    Patent number: 5800819
    Abstract: A phytochemical composition for treating sickle cell disease is provided. The composition is a cold water extraction product of a mixture containing Piper guineenses seeds, Pterocarpus osum stem, Eugenia caryophyllum fruit, Sorghum bicolor leaves and potash.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: September 1, 1998
    Assignee: National Institute for Pharmaceutical Research and Development Federal Ministry of Science and Technology
    Inventors: Charles Wambebe, P. O. Ogunyale, K. S. Gamaniel, R. N. Nasipuri, J. I. Okogun, Babatunde Samuel, Akin Olusola, Abayomi Orisadipe