Patents Assigned to National Institutes for Quantum and Radiological Science and Technology
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Publication number: 20240083893Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.Type: ApplicationFiled: May 8, 2023Publication date: March 14, 2024Applicant: National Institutes for Quantum and Radiological Science and TechnologyInventors: Makoto HIGUCHI, Tetsuya SUHARA, Masahiro MARUYAMA, Meiei CHO, Hitoshi SHIMADA
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Patent number: 11913910Abstract: A measuring device for measuring an inspection target on the basis of vibration generated when the inspection target has been irradiated with laser light includes a condensing position deriving portion configured to derive an amount of adjustment of a distance between condensing lenses of a laser condensing unit configured to condense the laser light on the basis of a distance between a laser device configured to radiate the laser light and an irradiation location of the laser light and a communicating portion configured to transmit control information including information representing the amount of adjustment to the laser condensing unit.Type: GrantFiled: April 17, 2023Date of Patent: February 27, 2024Assignee: National Institutes for Quantum and Radiological Science and TechnologyInventors: Katsuhiro Mikami, Toshiyuki Kitamura, Shuji Kondo, Hajime Okada, Tetsuya Kawachi, Yoshinori Shimada, Shinri Kurahashi, Masaharu Nishikino, Noboru Hasegawa
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Patent number: 11737705Abstract: An implant installation strength evaluation method includes a step of vibrating an implant, a step of measuring time series data of the number of vibrations and vibration strengths of the implant vibrated in the vibrating step, and a step of deriving information indicating an index of an installation strength of the implant based on the time series data of the number of vibrations and vibration strengths of the implant.Type: GrantFiled: September 13, 2018Date of Patent: August 29, 2023Assignees: KEIO UNIVERSITY, NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGYInventors: Daisuke Nakashima, Takeo Nagura, Masaharu Nishikino, Noboru Hasegawa, Katsuhiro Mikami, Toshiyuki Kitamura, Shuji Kondo, Hajime Okada, Yoshinori Shimada
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Patent number: 11674933Abstract: A measuring device for measuring an inspection target on the basis of vibration generated when the inspection target has been irradiated with laser light includes a condensing position deriving portion configured to derive an amount of adjustment of a distance between condensing lenses of a laser condensing unit configured to condense the laser light on the basis of a distance between a laser device configured to radiate the laser light and an irradiation location of the laser light and a communicating portion configured to transmit control information including information representing the amount of adjustment to the laser condensing unit.Type: GrantFiled: March 27, 2019Date of Patent: June 13, 2023Assignee: National Institutes for Quantum and Radiological Science and TechnologyInventors: Masaharu Nishikino, Noboru Hasegawa, Katsuhiro Mikami, Toshiyuki Kitamura, Shuji Kondo, Hajime Okada, Tetsuya Kawachi, Yoshinori Shimada, Shinri Kurahashi
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Patent number: 11667628Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.Type: GrantFiled: September 16, 2021Date of Patent: June 6, 2023Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGYInventors: Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Meiei Cho, Hitoshi Shimada
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Patent number: 11150252Abstract: Disclosed is a method for measuring phosphorylated tau protein in a biological sample collected from a subject, comprising the steps of: preparing a measurement sample containing a non-capture bead and a capture bead to which an immune complex is bound, by forming the immune complex of the phosphorylated tau protein in the biological sample, a capture antibody and a detection antibody on the capture bead, in the presence of the non-capture bead; and detecting a signal derived from the immune complex in the measurement sample.Type: GrantFiled: July 30, 2018Date of Patent: October 19, 2021Assignees: SYSMEX CORPORATION, National Institutes for Quantum and Radiological Science and TechnologyInventors: Takahiko Tokuda, Harutsugu Tatebe
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Publication number: 20210275696Abstract: The purpose of the present invention is to provide a technique for imaging the brain of a live animal and application of the technique. A radiolabeled dibenzoazepine derivative, which shows excellent brain parmeability, high receptor selectivity and high quantitativity, is used for imaging a live animal body. A dibenzoazepine derivative is used for treating a disease in which hM4D receptor or hM3D receptor participates. Further, a radiolabeled dibenzoazepine derivative is used for imaging an axonal end which is innervated by a nerve cell.Type: ApplicationFiled: June 21, 2019Publication date: September 9, 2021Applicant: National Institutes for Quantum and Radiological Science and TechnologyInventors: Takafumi MINAMIMOTO, Yuji NAGAI, Bin JI, Naohisa MIYAKAWA, Makoto HIGUCHI, Tetsuya SUHARA
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Publication number: 20210128089Abstract: An analysis apparatus according to an embodiment includes an extraction unit, a calculation unit, and an evaluation unit. The extraction unit extracts a detection value in a tumor region, a blood region, and a muscle region from a nuclear medicine image of a subject administered with a drug containing a radiolabeled anticancer drug that works by accumulating in a tumor. The calculation unit calculates a first comparison value that is a comparison result between the detection value in the blood region and the detection value in the tumor region, and a second comparison value that is a comparison result between the detection value in the muscle region and the detection value in the tumor region. The evaluation unit evaluates an accumulation of the drug in the tumor, based on the first comparison value and the second comparison value calculated by the calculation unit.Type: ApplicationFiled: October 27, 2020Publication date: May 6, 2021Applicants: CANON MEDICAL SYSTEMS CORPORATION, National Institutes for Quantum and Radiological Science and Technology, General Incorporated Association The Japan-Multinational Trial OrganizationInventors: Shunsuke FUJIWARA, Yasuo SAKURAI, Ming-Rong ZHANG, Lin XIE, Masayuki FUJINAGA, Masayuki HANYU, Cheng-Long HUANG, Masakazu FUKUSHIMA, Hiromi WADA
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Patent number: 10942235Abstract: PET or SPECT insert for MRI or MRS system with medium (3 T for example) to ultra high (7 T for example) magnetic field is provided. RF shielded radiation detector modules are separately disposed in a form of full or partial ring shape. The RF shielded radiation detector modules are electric ground conductors for microstrip transmission line coil RF array. Decoupling circuits in between grounded shield and/or in between microstrip conductors make electric isolation between coil elements.Type: GrantFiled: March 28, 2019Date of Patent: March 9, 2021Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGYInventors: Md Shahadat Hossain Akram, Takayuki Obata, Taiga Yamaya
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Publication number: 20210038125Abstract: The concentration of substance in blood is measured non-invasively, with high accuracy and with simple configuration. Laser light 100 generated by a light source 10 is locally irradiated on the body epithelium F of a subject, and the resulting diffused reflected light 200 is detected by a light detector 40. The laser light 100 has a wavelength of 9.26 ?m. The laser light 100 is generated by converting and amplifying pulsed excitation light 101 from an excitation light source 11 to a long wavelength. A plate-shaped window 300 that is transparent to mid-infrared light is brought in close contact with the body epithelium F. The glucose concentration in interstitial fluid can be calculated using normalized light intensity calculated from a signal ratio of signals from a monitoring light detector 16 and light detector 40.Type: ApplicationFiled: September 29, 2020Publication date: February 11, 2021Applicant: National Institutes for Quantum and Radiological Science and TechnologyInventor: Koichi YAMAKAWA
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Publication number: 20200396824Abstract: A control method for an accelerator according to the present embodiment is a control method for an accelerator that supplies a current generating a magnetic field to a plurality of deflection electromagnets based on a current-value instruction signal. The method includes providing a flat region that makes a current value of the deflection electromagnet constant in a case of an acceleration cycle involving emission of the charged particles, not providing the flat region in the current-value instruction signal in a case of an acceleration cycle, smoothing time change of a current value in a transition of the current value to the flat region or a transition from the flat region, and determining a time required for the smoothing based on a predetermined energy for extracting the charged particles or a difference between energies before and after change to the predetermined extraction energy.Type: ApplicationFiled: September 1, 2020Publication date: December 17, 2020Applicants: TOSHIBA ENERGY SYSTEMS & SOLUTIONS CORPORATION, NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGYInventors: Munemichi Matsumoto, Takuji Furukawa, Kota Mizushima, Katsushi Hanawa
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Publication number: 20200360544Abstract: This radioactive antitumor agent comprises a radioactive dithiosemicarbazone-copper complex as an active ingredient, and is characterized by being used in such a way that the radioactive dithiosemicarbazone-copper complex is administered multiple times to an organism requiring tumor treatment, at a radioactive dose that avoids dose-limiting toxicity, as determined on the basis of hematological parameters. The multiple administration preferably consists of intermittent administration at time intervals allowing the hematological parameters to return to a normal range.Type: ApplicationFiled: October 26, 2018Publication date: November 19, 2020Applicant: National Institutes for Quantum and Radiological Science and TechnologyInventors: Yukie YOSHII, Hiroki MATSUMOTO
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Patent number: 10806385Abstract: The concentration of substance in blood is measured non-invasively, with high accuracy and with simple configuration. Laser light generated by a light source is locally irradiated on the body epithelium of a subject, and the resulting diffused reflected light is detected by a light detector. The laser light has a wavelength of 9.26 ?m. The laser light is generated by converting and amplifying pulsed excitation light from an excitation light source to a long wavelength. A plate-shaped window that is transparent to mid-infrared light is brought in close contact with the body epithelium. The glucose concentration in interstitial fluid can be calculated using normalized light intensity calculated from a signal ratio of signals from a monitoring light detector and light detector.Type: GrantFiled: January 19, 2016Date of Patent: October 20, 2020Assignee: National Institutes for Quantum and Radiological Science and TechnologyInventor: Koichi Yamakawa
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Patent number: 10792516Abstract: A beam irradiation target verification apparatus includes an X-ray switching emission process unit that causes a vertical X-ray emitting unit to emit at least two types of X-rays using an energy-level switching unit, a vertical X-ray detection unit that detects an X-ray emitted from the vertical X-ray emitting unit, a pre-therapy verification image generation process unit, a reference image acquisition unit that acquires a reference image obtained at a therapy planning stage, a comparison process unit. The pre-therapy verification image generation process unit to generate pre-therapy verification images based on detection information of at least two types of X-rays obtained by the vertical X-ray detection unit. The comparison process unit makes comparisons between the pre-therapy verification images and the reference image, and the result output unit outputs a comparison result obtained by the comparison process unit.Type: GrantFiled: June 10, 2015Date of Patent: October 6, 2020Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGYInventors: Taku Inaniwa, Takuji Furukawa, Koji Noda
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Publication number: 20200231924Abstract: Provided are a substrate for test use that is preferable for use in a test such as a culture test, and a method for manufacturing the substrate for test use. The substrate for test use, in which a solution retaining part for retaining water or an aqueous solution, is formed at a surface of a substrate of polydimethylsiloxane (PDMS). The solution retaining part is a concave part having a hydrophilic surface layer. The surface layer has a maximum thickness of 1 ?m or larger.Type: ApplicationFiled: May 17, 2018Publication date: July 23, 2020Applicants: IWASAKI ELECTRIC CO., LTD., NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGYInventors: Shinobu KINOSHITA, Takashi IDE, Tomoko OYAMA, Mitsumasa TAGUCHI, Bin Jeremiah Duenas BARBA
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Publication number: 20200205730Abstract: An implant installation strength evaluation method includes a step of vibrating an implant, a step of measuring time series data of the number of vibrations and vibration strengths of the implant vibrated in the vibrating step, and a step of deriving information indicating an index of an installation strength of the implant based on the time series data of the number of vibrations and vibration strengths of the implant.Type: ApplicationFiled: September 13, 2018Publication date: July 2, 2020Applicants: KEIO UNIVERSITY, NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGYInventors: Daisuke NAKASHIMA, Takeo NAGURA, Masaharu NISHIKINO, Noboru HASEGAWA, Katsuhiro MIKAMI, Toshiyuki KITAMURA, Shuji KONDO, Hajime OKADA, Yoshinori SHIMADA
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Patent number: 10689766Abstract: The disclosure relates to recovering Li ions in a raw liquid into a recovery liquid at a high recovery speed. A lithium selective permeable membrane is constituted of a selective permeable membrane main body constituted of a lithium ion superconductor (ion conductor) having a particularly high ion conductivity and a Li adsorption layer formed as a thin layer on a raw liquid side (a first electrode) thereof. As a material constituting the selective permeable membrane main body, specifically, lanthanum lithium titanium oxide can be used. The Li adsorption layer is formed as a thin layer on a surface of the selective permeable membrane main body by carrying out a chemical treatment on the selective permeable membrane main body.Type: GrantFiled: January 26, 2017Date of Patent: June 23, 2020Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGYInventor: Tsuyoshi Hoshino
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Patent number: 10627466Abstract: A PET/MRI device includes an MRI device that has a measurement port, a PET detector that can be inserted into the measurement port, and a mechanism that can slide the PET detector into and out of the MRI measurement port. Thereby, the PET/MRI device allows MRI measurement during PET measurement.Type: GrantFiled: January 11, 2017Date of Patent: April 21, 2020Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGYInventors: Taiga Yamaya, Takayuki Obata
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Patent number: 10604516Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and ??[Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.Type: GrantFiled: December 21, 2012Date of Patent: March 31, 2020Assignee: National Institutes for Quantum and Radiological Science and TechnologyInventors: Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Meiei Cho, Hitoshi Shimada
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Patent number: 10533130Abstract: Provided are a charged particle radiation measuring method and a charged particle radiation measuring device using a scintillator comprising a phosphor in which the main component is a SiAlON phosphor.Type: GrantFiled: May 17, 2019Date of Patent: January 14, 2020Assignees: Denka Company Limited, National University Corporation Gunma University, National Institutes For Quantum And Radiological Science And TechnologyInventors: Wataru Kada, Kenta Miura, Osamu Hanaizumi, Tomihiro Kamiya, Takahiro Satoh, Junichi Susaki, Suzuya Yamada