Patents Assigned to National Research Council of Canada
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Patent number: 11966076Abstract: An optical fiber transducer usable in environments of extreme operating temperature features a stationary support, a movable body displaceable back and forth relative thereto, and an optical fiber connected between the support and the movable body. The fiber has a Fiber Bragg Grating in an intermediate region thereof between the support and movable body. To accommodate varying coefficients of thermal expansion (CTEs) among these components, one or more tubes close circumferentially around the fiber. Each tube has a CTE that is greater than that of the fiber, and less than that of the constituent material of the support and movable body. The fiber is bonded to an interior of the tube(s), while an exterior of the tube(s) is bonded to the support and movable body.Type: GrantFiled: February 19, 2021Date of Patent: April 23, 2024Assignee: National Research Council of CanadaInventors: Richard Green, Lixue Wu, Michael Bakaic
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Patent number: 11958048Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.Type: GrantFiled: February 27, 2022Date of Patent: April 16, 2024Assignee: National Research Council of CanadaInventors: Ryan Denomme, Lidija Malic, Daniel Brassard, Keith Morton, Teodor Veres
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Patent number: 11955172Abstract: An atomic orbital based memory storage is provided that includes a plurality of surface atoms forming dangling bonds (DBs) and a subset of the plurality of surface atoms passivated with spatial control to form covalent bonds with hydrogen, deuterium, or a combination thereof. The atomic orbital based data storage that can be rewritten and corrected as needed. The resulting data storage is also archival and capable of high data densities than any known storage as the data is retained in a binary storage or a given orbital being passivated or a dangling bond (DB). A method of forming and reading the atomic orbital data storage is also provided. The method including selectively removing covalent bonds to form dangling bonds (DBs) extending from a surface atom by hydrogen lithography and imaging the covalent bonds spatially to read the atomic orbital data storage.Type: GrantFiled: November 28, 2022Date of Patent: April 9, 2024Assignees: National Research Council of Canada, Quantum Silicon Inc., The Governors of the University of AlbertaInventors: Roshan Achal, Robert A. Wolkow, Jason Pitters, Martin Cloutier, Mohammad Rashidi, Marco Taucer, Taleana Huff
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Patent number: 11945858Abstract: The present disclosure concerns antibodies specific for the Na v.7 polypeptides which are capable of antagonizing the biological activity of the Na v.7 polypeptide. The anti-Na v.7 antibodies can be used for alleviating the symptoms of pain and/or for treating or alleviating the symptoms of an hyperproliferative disease. The presence disclosure also concerns immunogens and methods for making antibodies, such as the anti-Na v.7 antibodies, comprising a single-domain antibody.Type: GrantFiled: May 17, 2019Date of Patent: April 2, 2024Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Marzia Martina, Balu Chakravarthy, Yves Durocher, Mehdi Arbabi-Ghahroudi, Anne Marcil, Danica Stanimirovic, Traian Sulea, Maria Moreno, Umberto Banderali
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Publication number: 20240101641Abstract: The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-?) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.Type: ApplicationFiled: August 29, 2023Publication date: March 28, 2024Applicant: National Research Council of CanadaInventors: Anne E.G. LENFERINK, John C. Zwaagstra, Traian Sulea, Maureen D. O'Connor-McCourt
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Patent number: 11939614Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.Type: GrantFiled: March 10, 2022Date of Patent: March 26, 2024Assignees: National Research Council of Canada, University of SaskatchewanInventors: Jonathan E. Page, Steve Gagne
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Publication number: 20240076406Abstract: The present disclosure relates to a single domain antibody that specifically binds to the epitope in the catalytic domain of carbonic anhydrase IX (CA-IX). The single domain antibody has a dissociation constant (KD) of 1×10?7 or lower for a monomeric form of human CA-IX and/or a dimeric form of human CA-IX.Type: ApplicationFiled: January 21, 2022Publication date: March 7, 2024Applicant: National Research Council of CanadaInventors: Anne EG LENFERINK, Mehdi ARBABI GHAHROUDI, Nazanin ROHANI LARIJANI, Scott MCCOMB
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Publication number: 20240076389Abstract: AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.Type: ApplicationFiled: June 27, 2023Publication date: March 7, 2024Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Kevin HENRY, Maria Luz JARAMILLO, Colin Roger MACKENZIE, Anne MARCIL
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Publication number: 20240053300Abstract: Described are various embodiments of an ultrasonic structural health monitoring device, system and method. In one embodiment, an ultrasonic structural health monitoring device is described to monitor a structure. The device comprises a bottom electrode disposable on the structure; a piezoelectric medium disposed on the bottom electrode; a top electrode disposed on the piezoelectric medium; an acoustic insulation layer; and a connector to bring electrical excitation for the piezoelectric medium and to collect a generated electric response therefrom representative of structural health.Type: ApplicationFiled: August 20, 2021Publication date: February 15, 2024Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Silvio Elton KRUGER, David ROCHELEAU, Zhigang SUN, Kuo-Ting WU
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Publication number: 20240010686Abstract: Methods and compositions for increasing the production of large amounts of empty capsids of the foot-and-mouth disease virus (FMDV) in a stable manner in mammalian cells by regulating the expression of FMDV 3C protease. The instant methods and compositions are based on the fact that a decreased expression of 3C protease results in a reduced cell toxicity and an increased synthesis of viral capsid proteins, as well as production of recombinant empty capsids. The invention provides recombinant plasmids that direct the expression of P1, 3C, and the use of the plasmids for producing new stable cell lines capable of generating high titers of FMDV empty capsids. The invention provides methods for regulating the expression of the FMDV 3C protease gene at a transcriptional and translational level in order to achieve the required process level of 3C protease for the selection process, as well as the production process.Type: ApplicationFiled: November 9, 2021Publication date: January 11, 2024Applicants: Instituto Nacional de Tecnologia Agropecuaria, National Research Council of CanadaInventors: Ana Clara Mignaqui, Andres Wigodorovitz, Yves Durocher
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Patent number: 11867320Abstract: In a polymeric microfluidic valve, an adhesion control surface with discrete micro- or nano-scale structured surfaces are separated by fluid filled voids at an interface between an elastomeric membrane seals against a substrate layer. The structured surfaces reduce adhesion between the membrane layer and the substrate layer and prevent permanent bonding, while at the same time providing a good balance of adhesion at the valve seat to provide a sealing engagement. Microstructured adhesion control surfaces on and around valve bodies permit opening the valve, by reducing contact surface area.Type: GrantFiled: March 4, 2019Date of Patent: January 9, 2024Assignee: National Research Council of CanadaInventors: Kebin Li, Keith Morton, Teodor Veres
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Patent number: 11866481Abstract: The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-?) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.Type: GrantFiled: March 1, 2018Date of Patent: January 9, 2024Assignee: National Research Council of CanadaInventors: Anne E. G. Lenferink, John C. Zwaagstra, Traian Sulea, Maureen D. O'Connor-McCourt
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Publication number: 20240001565Abstract: The use of an unctuous sealing material (high viscosity liquid bordering on, or having, solid behavior at low shear forces) for sealing open pore, highly crushable suction cups allows for increased surface conformation for fast secure vacuum gripping, and maintenance of the pressure differential with lower energy in view of the seal. Furthermore, fast grasping is demonstrated if the unctuous sealing material protrudes from the lip.Type: ApplicationFiled: December 2, 2021Publication date: January 4, 2024Applicant: National Research Council of CanadaInventors: Charles VIDAL, Alexis GERARD, Martin DE MONTIGNY, Bruno MONSARRAT, Iraj MANTEGH, Bruno CHAPDELAINE
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Patent number: 11845234Abstract: A vacuum bag system (VBS) for forming pre-consolidated composite blanks has a blank enclosure for sealing around a periphery of the blank, while leaving a second side of the blank exposed, an articulated forming caul (AFC) with at least two facets, each facet effectively jointedly coupled to an adjacent facet, and having a respective, independently controlled, heater integrated with, or coupled to the facet. The VBS further has a forming enclosure for sealing around a periphery of a tool. The blank enclosure brings the blank and the facets into uniform thermal contact resistance and mechanical contact; and permits the articulated AFC to distribute thermal and mechanical load across the blank during forming, even as the facets move to align to faces of the mold.Type: GrantFiled: January 24, 2020Date of Patent: December 19, 2023Assignee: National Research Council of CanadaInventors: Ali Yousefpour, Drazen Djokic, Simon Hind, Meysam Rahmat, Steven Roy, Marc-Andre Octeau, Jihua Chen
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Patent number: 11837681Abstract: An avalanche photodiode with a diffused junction and the method for its fabrication are disclosed. The method comprising forming, on a substrate, a first high-doped region and a low-doped region; performing selective area growth (SAG) with in-situ etchant on the low-doped region to grow a SAG structure; and diffusing through the SAG structure to form a second high-doped region in the low-doped region.Type: GrantFiled: December 9, 2019Date of Patent: December 5, 2023Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Oliver Pitts, Omid Salehzadeh Einabad
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Patent number: 11820975Abstract: An in vitro population of human brain endothelial cells (hBECs) expressing claudin-5, occludin, ZO-1 and GLUT-1 and expressing one or more of FZD7, WNT7A, WNT7B, APCDD1, STRA6 and ZO-3 is provided. A blood brain barrier (BBB) comprising the hBECs and use of the BBB for analyzing permeability characteristics of a test agent are provided.Type: GrantFiled: December 9, 2015Date of Patent: November 21, 2023Assignee: National Research Council of CanadaInventors: Mahmud Bani, Danica Stanimirovic, Maria Ribecco-Lutkiewicz
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Patent number: 11819021Abstract: Novel activators of the APC complex and methods and uses of these activators are provided. In particular, the activators are used for increasing resistance to stress and/or increasing lifespan in a plant or mammalian cell, in a plant or mammalian embryo or in a plant or subject. The activators are also used for treating cancer in a subject.Type: GrantFiled: April 4, 2018Date of Patent: November 21, 2023Assignee: University of Saskatchewan & National Research Council of CanadaInventors: Troy Harkness, Terra Gayle Arnason, Pankaj Bhowmik
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Publication number: 20230357566Abstract: Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer matrix comprising a first polymer material and a second polymer material that are immiscible with each other, and a plurality of piezoelectric particles located in at least a portion of the polymer matrix. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.Type: ApplicationFiled: March 22, 2022Publication date: November 9, 2023Applicants: XEROX CORPORATION, NATIONAL RESEARCH COUNCIL OF CANADAInventors: Sarah J. VELLA, Alexandros VASILEIOU, Yujie ZHU, Edward G. ZWARTZ, Chantal PAQUET, Silvio E. KRUGER, Mohammad RAFIEE, Yujie ZHANG, Thomas LACELLE, Derek ARANGUREN VAN EGMOND, Claudie ROY
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Publication number: 20230361637Abstract: An electrical machine, which may be a motor and/or a generator has a rotor mounted to rotate about an axis. A plurality of magnetic poles are spaced circumferentially around the rotor in the bore. The rotor comprises a shell shaped to provide a toroidal bore centered on the axis. A slit extends circumferentially around the rotor. The slit penetrates through the shell into the bore. The electrical machine also includes a stator that is supported in the bore by one or more supports extending through the slit of the rotor. The stator carries plural windings that are spaced apart around the bore.Type: ApplicationFiled: September 16, 2021Publication date: November 9, 2023Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Maged IBRAHIM, Fabrice BERNIER, Jean-Michel LAMARRE
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Patent number: 11795190Abstract: Heptose-1-monophosphate-7-derivatives are modifiable immunomodulators that can be used to prepare clinically active conjugate compounds. Such conjugate compounds are useful in modulating an immune response in a subject.Type: GrantFiled: December 29, 2018Date of Patent: October 24, 2023Assignees: NATIONAL RESEARCH COUNCIL OF CANADA, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Janelle Sauvageau, Andrew Cox, Xinyi Guo, Scott Gray-Owen