Patents Assigned to National University Corporation Kanazawa University
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Patent number: 8300912Abstract: Using nature that a pixel value in a lung of a chest X-ray moving image varies due to heart beat, the variation information on the pixel value is effectively used for diagnosis such as of a lung embolism or a heart disease, considering the variation information as lung blood flow information. A continuous X-ray image screening examination device receives a chest X-ray moving image from an X-ray detector and receives an electrocardiogram to become original information on a heart beat variation from an electrocardiogram recording apparatus. From the dynamic state of the heart wall measured by the electrocardiograph or the chest X-ray moving image, the heart dynamic state during the cardiac chamber systolic and diastolic phases is grasped, and information such as the variation of the pixel value of the chest X-ray moving image due to increase (lung blood flow increase) of the blood flow from the heart to the lung during the cardiac chamber systolic phase is generated.Type: GrantFiled: January 5, 2007Date of Patent: October 30, 2012Assignee: National University Corporation Kanazawa UniversityInventors: Shigeru Sanada, Rie Tanaka, Nobuo Okazaki
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Patent number: 8282936Abstract: The object of the present invention is to provide an edible vaccine which is effective for human papilloma virus (HPV) type 16 and available in large amounts inexpensively. An edible human papilloma virus vaccine obtained by culturing a transformant of an avirulent fission yeast host, wherein the transformant carries a gene encoding an antigenic protein of human papilloma virus introduced therein and accumulates the expressed antigenic protein in it.Type: GrantFiled: May 7, 2008Date of Patent: October 9, 2012Assignees: Asahi Glass Company, Ltd., National University Corporation Kanazawa UniversityInventors: Toshiyuki Sasagawa, Hideki Tohda, Yuko Hama
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Patent number: 8227378Abstract: An arsenic sorbent includes monohydrocalcite that has been precipitated by mixing an aqueous solution of a soluble carbonate or a carbonate with an aqueous solution that includes an Mg2+ ion and a Ca2+ ion in a ratio “Mg/Ca” of 0.3 or more, the monohydrocalcite having a molar ratio “Mg/(Ca+Mg)” of 0.1 or less. The arsenic sorbent exhibits a high arsenic sorption ability, and can stably retain a sorbate. A purification method using the same is also disclosed.Type: GrantFiled: July 28, 2011Date of Patent: July 24, 2012Assignee: National University Corporation Kanazawa UniversityInventors: Keisuke Fukushi, Minoru Sakai, Takashi Munemoto
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Patent number: 8222004Abstract: The invention relates to a method for screening a pharmaceutical for treating or preventing a neurodevelopmental disorder or a psychiatric disorder accompanied by an abnormality of oxytocin system by using an increase in expression or enzymatic activity of CD38 as an index, and a diagnosis of a predisposition to a neurodevelopmental disorder or a psychiatric disorder accompanied by an abnormality of oxytocin system by using a mutation present in a CD38 gene region as an index.Type: GrantFiled: November 15, 2007Date of Patent: July 17, 2012Assignees: National University Corporation Kanazawa University, Tohoku UniversityInventor: Haruhiro Higashida
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Patent number: 8217367Abstract: A scanner device is provided which enables high-frequency scanning and can increase the speed of a scanning probe microscope. A scanner device (1) used for a scanning probe microscope includes a Z actuator (7) which scans an object to be scanned in a scanning direction, and a Z actuator holder (11) which holds the Z actuator (7). The Z actuator holder (11) holds the Z actuator (7) at a plurality of holding line parts which extend in the scanning direction and are separated from each other. For example, the Z actuator (7) has a rectangular cross-section, and the four edges of the Z actuator (7) are held by the Z actuator holder (11). The Z actuator (7) is pressed into a holding hole (29) of the Z actuator holder (11).Type: GrantFiled: May 29, 2009Date of Patent: July 10, 2012Assignee: National University Corporation Kanazawa UniversityInventors: Takeshi Fukuma, Toshio Ando, Yasutaka Okazaki
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Publication number: 20120012532Abstract: An arsenic sorbent includes monohydrocalcite that has been precipitated by mixing an aqueous solution of a soluble carbonate or a carbonate with an aqueous solution that includes an Mg2+ ion and a Ca2+ ion in a ratio “Mg/Ca” of 0.3 or more, the monohydrocalcite having a molar ratio “Mg/(Ca+Mg)” of 0.1 or less. The arsenic sorbent exhibits a high arsenic sorption ability, and can stably retain a sorbate. A purification method using the same is also disclosed.Type: ApplicationFiled: July 28, 2011Publication date: January 19, 2012Applicant: National University Corporation Kanazawa UniversityInventors: Keisuke FUKUSHI, Minoru SAKAI, Takashi MUNEMOTO
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Patent number: 8065908Abstract: Provided is an atomic force microscope capable of increasing the phase detection speed of a cantilever vibration. The cantilever (5) is excited and the cantilever (5) and a sample are relatively scanned. Displacement of the cantilever (5) is detected by a sensor. An oscillator (27) generates an excitation signal of the cantilever (5) and generates a reference wave signal having a frequency based on the excitation signal and a fixed phase. According to vibration of the cantilever (5), a trigger pulse generation circuit (41) generates a trigger pulse signal having a pulse position changing in accordance with the vibration of the cantilever (5). According to the reference wave signal and the trigger pulse signal, a phase signal generation circuit (43) generates a signal corresponding to the level of the reference wave signal at the pulse position as a phase signal of vibration of the cantilever (5). As the reference wave signal, a saw tooth wave is used.Type: GrantFiled: December 12, 2006Date of Patent: November 29, 2011Assignee: National University Corporation Kanazawa UniversityInventors: Takayuki Uchihashi, Toshio Ando, Hayato Yamashita
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Patent number: 8000481Abstract: A speaker array, includes a plurality of speakers which are linearly arranged at a predetermined interval; and one-dimensional digital filters which are provided to correspond to the speakers respectively, in which predetermined filter coefficients are set previously, and which apply a filtering process to input sound data in response to the filter coefficients to output. Sound data derived by applying a digital conversion to input sound signals are supplied to respective one-dimensional digital filters. Sound signals derived by applying an analog conversion to the sound data output from respective one-dimensional digital filters are supplied to corresponding speakers to output a sound in response to the sound signals.Type: GrantFiled: October 12, 2006Date of Patent: August 16, 2011Assignees: Yamaha Corporation, National University Corporation, Kanazawa UniversityInventor: Kiyoshi Nishikawa
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Patent number: 7975315Abstract: There is provided an atomic force microscope (AFM) with increase the speed and sensitivity of detection of the resonant frequency shift in a cantilever. An AFM (1) extracts a reference signal and a phase shift signal from a detection signal from a displacement sensor of the cantilever. The reference signal is restrained from a phase change in accordance with the resonant frequency shift. The phase shift signal has a phase shifted in accordance with the resonant frequency shift. The AFM (1) determines the phase difference of the phase shift signal from the reference signal, as the resonant frequency shift. The AFM (1) may detect the phase difference between a plus-minus inversion point on the reference signal and a corresponding plus-minus inversion point on the phase shift signal. The AFM (1) may adjust phase before phase detection. The phase adjustment may move the detection point for the resonant frequency shift defined on the oscillation waveforms to the plus-minus inversion point.Type: GrantFiled: July 27, 2007Date of Patent: July 5, 2011Assignee: National University Corporation Kanazawa UniversityInventors: Toshio Ando, Takayuki Uchihashi, Noriyuki Kodera, Naohisa Takahashi
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Patent number: 7975314Abstract: There is provided a scanning probe microscope that allows active damping to be advantageously carried out. A Z scan control section functions as a driving control section to control a Z scanner that is a controlled object. Driving control is performed by supplying the controlled object with a driving signal processed by an adjustment function. The adjustment function adjusts the driving signal by using a simulated transfer function that simulates an actual transfer function indicative of an actual frequency characteristic of the controlled object so that executing processing of the simulated transfer function on the adjusted driving signal results in decrease of vibration of an output signal from the simulated transfer function.Type: GrantFiled: July 27, 2007Date of Patent: July 5, 2011Assignee: National University Corporation Kanazawa UniversityInventor: Toshio Ando
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Patent number: 7958565Abstract: A driving laser unit (11) irradiates a laser beam on a cantilever (5) to cause thermal expansion deformation. A driving-laser control unit (13) performs feedback control for the cantilever (5) by controlling intensity of the laser beam on the basis of displacement of the cantilever (5) detected by a sensor (9). A thermal-response compensating circuit (35) has a constitution equivalent to an inverse transfer function of a heat transfer function of the cantilever (5) and compensates for a delay in a thermal response of the cantilever (5) to the light irradiation. Moreover, the cantilever (5) may be excited by controlling the intensity of the laser beam. By controlling light intensity, a Q value of a lever resonance system is also controlled. It is possible to increase scanning speed of an atomic force microscope.Type: GrantFiled: May 26, 2006Date of Patent: June 7, 2011Assignee: National University Corporation Kanazawa UniversityInventors: Toshio Ando, Takayuki Uchihashi, Noriyuki Kodera, Hayato Yamashita
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Patent number: 7954165Abstract: A scanning probe microscope is provided, which can be stably used for a long time even if excitation efficiency varies during scan. A cantilever (5) is excited, and the cantilever (5) and a sample are subjected to relative scanning. A second-harmonic component detection circuit (31) detects second-harmonic component amplitude of oscillation of the cantilever (5) as integral-multiple component amplitude. The second-harmonic component amplitude is amplitude of a second-harmonic component having a frequency twice as high as excitation frequency. An excitation intensity adjustment circuit (33) controls excitation intensity based on the detected second-harmonic component amplitude such that the second-harmonic component amplitude is kept constant.Type: GrantFiled: October 12, 2006Date of Patent: May 31, 2011Assignee: National University Corporation Kanazawa UniversityInventors: Toshio Ando, Mitsuru Sakashita, Takayuki Uchihashi
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Publication number: 20110112264Abstract: A production process of a polymerization catalyst of an alkylene oxide, comprising a step of contacting an alumoxane compound with a compound having a hydroxyl group; a production process of a pre-polymerized polymerization catalyst thereof, comprising a step of pre-polymerizing an alkylene oxide in the presence of the above polymerization catalyst; and a production process of a poly(alkylene oxide), comprising a step of polymerizing an alkylene oxide in the presence of the above polymerization catalyst or pre-polymerized polymerization catalyst.Type: ApplicationFiled: October 26, 2010Publication date: May 12, 2011Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, National University Corporation Kanazawa UniversityInventors: Shigeyoshi KANOH, Masaaki NABIKA
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Patent number: 7939307Abstract: Modified CueO having excellent enzymatic activity and a composition for dyeing keratin fiber which contains the enzyme. A recombinant protein having an enzymatic activity for oxidizing p-phenylenediamine, the protein is obtained by removing from CueO at least one member selected from the group consisting of helix 5, helix 6, and helix 7; and the composition for dyeing keratin fiber containing the recombinant protein and an oxidation dye.Type: GrantFiled: April 14, 2006Date of Patent: May 10, 2011Assignees: National University Corporation Kanazawa University, Mandom CorporationInventors: Kaori Otsuka, Yoshio Tsujino, Yusuke Konno, Shinji Kurose, Kunishige Kataoka, Takeshi Sakurai
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Publication number: 20100161021Abstract: This invention relates to a myocardial pad used in cardioversion, pacing, or the like and to a myocardial lead and a therapeutic apparatus for cardiac disease comprising the same. The myocardial pad of this invention is bondable to epicardia and has conductivity, biocompatibility, and biodegradability. Using this pad, the myocardial lead can be immobilized onto the atrium without suture. Thus, bleeding from the atrium, which is a lethal complication, caused by lead removal can be prevented.Type: ApplicationFiled: June 7, 2007Publication date: June 24, 2010Applicants: National University Corporation Kanazawa University, Japan Advanced Institute Of Science And TechnologyInventors: Kenji Iino, Go Watanabe, Nobuhiko Yui, Tooru Ooya, Ryoji Kawabata
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Publication number: 20100024082Abstract: There is provided an atomic force microscope (AFM) with increase the speed and sensitivity of detection of the resonant frequency shift in a cantilever. An AFM (1) extracts a reference signal and a phase shift signal from a detection signal from a displacement sensor of the cantilever. The reference signal is restrained from a phase change in accordance with the resonant frequency shift. The phase shift signal has a phase shifted in accordance with the resonant frequency shift. The AFM (1) determines the phase difference of the phase shift signal from the reference signal, as the resonant frequency shift. The AFM (1) may detect the phase difference between a plus-minus inversion point on the reference signal and a corresponding plus-minus inversion point on the phase shift signal. The AFM (1) may adjust phase before phase detection. The phase adjustment may move the detection point for the resonant frequency shift defined on the oscillation waveforms to the plus-minus inversion point.Type: ApplicationFiled: July 27, 2007Publication date: January 28, 2010Applicant: National University Corporation Kanazawa UniversityInventors: Toshio Ando, Takayuki Uchihashi, Noriyuki Kodera, Naohisa Takahashi
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Publication number: 20090313729Abstract: A driving laser unit (11) irradiates a laser beam on a cantilever (5) to cause thermal expansion deformation. A driving-laser control unit (13) performs feedback control for the cantilever (5) by controlling intensity of the laser beam on the basis of displacement of the cantilever (5) detected by a sensor (9). A thermal-response compensating circuit (35) has a constitution equivalent to an inverse transfer function of a heat transfer function of the cantilever (5) and compensates for a delay in a thermal response of the cantilever (5) to the light irradiation. Moreover, the cantilever (5) may be excited by controlling the intensity of the laser beam. By controlling light intensity, a Q value of a lever resonance system is also controlled. It is possible to increase scanning speed of an atomic force microscope.Type: ApplicationFiled: May 26, 2006Publication date: December 17, 2009Applicant: National University Corporation Kanazawa UniversityInventors: Toshio Ando, Takayuki Uchihashi, Noriyuki Kodera, Hayato Yamashita
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Patent number: 7620083Abstract: A semiconductor laser drive system and a semiconductor laser driving method where both internal noise and optical feedback noise can be simultaneously reduced are provided at low cost and low power consumption.Type: GrantFiled: August 31, 2006Date of Patent: November 17, 2009Assignee: National University Corporation Kanazawa UniversityInventor: Minoru Yamada
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Publication number: 20090215685Abstract: The present invention aims to provide a method for inhibiting hair depigmentation and a method for inhibiting hair loss, in which hair depigmentation and hair loss are inhibited by collagen XVII.Type: ApplicationFiled: February 22, 2008Publication date: August 27, 2009Applicant: National University Corporation Kanazawa UniversityInventors: Emi Nishimura, Hiroshi Shimizu, Shintaro Tanimura, Yuko Tadokoro, Daisuke Sawamura, Wataru Nishie
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Publication number: 20090133168Abstract: A scanning probe microscope is provided, which can be stably used for a long time even if excitation efficiency varies during scan. A cantilever (5) is excited, and the cantilever (5) and a sample are subjected to relative scanning. A second-harmonic component detection circuit (31) detects second-harmonic component amplitude of oscillation of the cantilever (5) as integral-multiple component amplitude. The second-harmonic component amplitude is amplitude of a second-harmonic component having a frequency twice as high as excitation frequency. An excitation intensity adjustment circuit (33) controls excitation intensity based on the detected second-harmonic component amplitude such that the second-harmonic component amplitude is kept constant.Type: ApplicationFiled: October 12, 2006Publication date: May 21, 2009Applicant: National University Corporation Kanazawa UniversityInventors: Toshio Ando, Mitsuru Sakashita, Takayuki Uchihashi