Patents Assigned to National University of Corporation Hiroshima University
  • Patent number: 10626141
    Abstract: The present invention provides a method for specifically cleaving a C?-C bond of a peptide backbone and/or a side chain of a protein and a peptide, and a method for determining amino acid sequences of protein and peptide. A method for specifically cleaving a C?-C bond of a peptide backbone and/or a side chain bond of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of at least one hydroxynitrobenzoic acid selected from the group consisting of 3-hydroxy-2-nitrobenzoic acid, 4-hydroxy-3-nitrobenzoic acid, 5-hydroxy-2-nitrobenzoic acid, 3-hydroxy-5-nitrobenzoic acid, and 4-hydroxy-2-nitrobenzoic acid. A method for determining an amino acid sequence of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of the above specific hydroxynitrobenzoic acid to specifically cleave a C?-C bond of a peptide backbone and/or a side chain bond, and analyzing generated fragment ions by mass spectrometry.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: April 21, 2020
    Assignees: SHIMADZU CORPORATION, NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITY
    Inventors: Shunsuke Izumi, Koichi Tanaka, Yuko Fukuyama
  • Patent number: 10461669
    Abstract: A wind power generation system including a power generation unit having an elastically deformable base material in a shape of a longitudinal flat plate and a piezoelectric element disposed on the base material, and which generates electricity as the power generation unit is vibrated; the piezoelectric element is repeatedly bent and deformed by the vibration and stacked on the base material, the wind power generation system being configured to include a tension adjusting device that, when a wind speed is increased, moves the movable member to increase a tensile force that pulls the power generation unit in the longitudinal direction, and the tension adjusting device being a lift generating member that is formed integrally with the movable member so as to be extended and to have wing shape to both sides of the movable member and that moves the movable member based on lift generated according to the wind speed.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: October 29, 2019
    Assignees: TOYODA IRON WORKS CO., LTD., NATIONAL UNIVERSITY CORPORATION HIROSHIMA UNIVERSITY
    Inventors: Hidenobu Takao, Yasuhiro Sone, Hidemi Mutsuda, Yoshikazu Tanaka
  • Publication number: 20190115434
    Abstract: Semiconductor devices each include: a semiconductor substrate that contains beta-gallium oxide and has a first conductivity type; a first semiconductor region that contains beta-gallium oxide, has the first conductivity type, and is provided on an upper side of the semiconductor substrate; a second semiconductor region that contains beta-gallium oxide, has a second conductivity type, and is provided on an upper side of a part of the first semiconductor region; and a third semiconductor region that contains beta-gallium oxide, has the first conductivity type, and is provided on an upper side of a part of the second semiconductor region. When the first conductivity type is an n-type and the second conductivity type is a p-type, the second semiconductor region further contains a band gap control element. The band gap control element is selected from a group of boron, aluminum, and indium.
    Type: Application
    Filed: October 15, 2018
    Publication date: April 18, 2019
    Applicants: Yazaki Corporation, National University Corporation Hiroshima University
    Inventors: Naotake SAKUMOTO, Yoshinori MATSUSHITA, Hiroki ISHIHARA, Tatsuo SUNAYAMA, Misako AIDA, Yoriko TOMINAGA, Dai AKASE
  • Patent number: 10075103
    Abstract: A power generation device for a mobile body includes power generating units and a holding member. Each power generating unit includes an elastically deformable base member and a piezoelectric film, which are laminated alternately. The holding member holds the power generating units. Each power generating unit has an elongated flat-plate shape. Opposite ends of the power generating unit in a longitudinal direction are held by the holding member such that the power generating unit is in an orientation in which a longitudinal axis is substantially perpendicular to the flow direction of the external fluid. A fixing member is provided at each of the opposite ends in the longitudinal direction of each power generating unit. The power generating units are arranged in the holding member via the fixing members to pivot in accordance with the flow of the external fluid.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: September 11, 2018
    Assignees: TOYODA IRON WORKS CO., LTD., NATIONAL UNIVERSITY CORPORATION HIROSHIMA UNIVERSITY
    Inventors: Hidenobu Takao, Yasuhiro Sone, Hidemi Mutsuda, Yoshikazu Tanaka
  • Patent number: 9453846
    Abstract: The present invention provides a mass spectrometry method using a matrix that is capable of easily and efficiently improving ionization efficiency in mass spectrometry without modifying a molecule to be analyzed, and a matrix for mass spectrometry. A mass spectrometry method using, as a matrix, a 2,4,6-trihydroxyalkylphenone represented by the following general formula (I): where R is an alkyl group having 4 to 12 carbon atoms. The mass spectrometry method as described above, wherein an analysis object is a hydrophobic compound, particularly, a hydrophobic peptide.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: September 27, 2016
    Assignees: SHIMADZU CORPORATION, NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITY
    Inventors: Yuko Fukuyama, Shunsuke Izumi
  • Patent number: 9312491
    Abstract: A photoelectric conversion element has a structure where a hole transport layer, a photoelectric conversion layer, and an electron transport layer are held between a first electrode and a second electrode. The photoelectric conversion layer is a bulk heterojunction layer, and fullerene or a fullerene derivative is used as an n-type organic semiconductor. As a p-type organic semiconductor, a polymer represented by the following Expression is used. In the Expression, R1, R2, R3, and R4 each independently represent any one of a branched alkyl group, a linear alkyl group, an alkyl ester group, a carboxy alkyl group, and an alkoxy group. Independently, X is any one of S, O, and N.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: April 12, 2016
    Assignees: JX NIPPON OIL & ENERGY CORPORATION, NATIONAL UNIVERSITY CORPORATION OF HIROSHIMA UNIVERSITY
    Inventors: Seunghun Eu, Tsuyoshi Asano, Itaru Osaka, Kazuo Takimiya
  • Patent number: 9209409
    Abstract: A naphthobisthiadiazole derivative is represented by Formula 1. In Formula 1, Z is selected from a hydrogen atom, a boronic acid group, a boronic acid ester group, a trifluoroborate salt group and a triolborate salt group, and at least one Z is a boronic acid group, a boronic acid ester group, a trifluoroborate salt group or a triolborate salt group. The naphthobisthiadiazole derivative is an organoboron compound, and can be converted to various compounds by a Suzuki-Miyaura coupling reaction; thus, is applicable as a precursor of complex compounds. Using the naphthobisthiadiazole derivative, research, development, and practical applications of low molecular weight compounds and high-molecular compounds useful for various organic semiconductor materials and the like can be ensured.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: December 8, 2015
    Assignees: National University of Corporation Hiroshima University, Sankyo Kasei Co., Ltd.
    Inventors: Kazuo Takimiya, Itaru Osaka, Kazuaki Kawashima
  • Patent number: 9018398
    Abstract: An intermediate for an acenedichalcogenophene derivative is expressed by formula (1) or formula (2). In the formulae (1) and (2), Ar1 represents any one ring of a benzene ring, a naphthalene ring, or an anthracene ring having at least one of hydrogen thereof is substituted with a boronic acid group or a boronate ester group; Y represents an oxygen atom, a sulfur atom, or a selenium atom; and Z represents a substituent group. This intermediate for the acenedichalcogenophene derivative is capable of easily deprotecting the boronic acid group or the boronate ester group and allowing a substitution with a desired functional group, such that a desired synthesis of acenedichalcogenophene derivative, and further a desired synthesis of oligomers and polymers using this obtained acenedichalcogenophene derivative can be achieved.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: April 28, 2015
    Assignee: National University of Corporation Hiroshima University
    Inventors: Kazuo Takimiya, Itaru Osaka
  • Patent number: 8921836
    Abstract: An object of the present invention is to provide a polymer compound providing high charge mobility. The polymer compound of the present invention has a repeating unit represented by the formula (1): wherein Ar1 and Ar2 are each an aromatic hydrocarbon ring, a heterocycle, or a fused ring of an aromatic hydrocarbon ring and a heterocycle; and R1, R2, R3 and R4 each represent a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an aryl group, an aryloxy group, an arylthio group, an arylalkyl group, an arylalkoxy group, an arylalkylthio group, a substituted silyl group, an unsubstituted or substituted carboxyl group, a monovalent heterocyclic group, a cyano group or a fluorine atom.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: December 30, 2014
    Assignees: Sumitomo Chemical Company, Limited, National University of Corporation Hiroshima University
    Inventors: Kazuo Takimiya, Itaru Osaka, Kenji Kohiro, Kenichiro Ohya, Kunihito Miyake
  • Patent number: 8771983
    Abstract: A method is disclosed for releasing the transcriptional regulation caused by a repeated sequence in a gene, a kit therefor and so on to thereby establish a system capable of producing a protein in a large amount.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: July 8, 2014
    Assignee: National University of Corporation Hiroshima University
    Inventor: Noriaki Shimizu
  • Publication number: 20140000716
    Abstract: A photoelectric conversion element has a structure where a hole transport layer, a photoelectric conversion layer, and an electron transport layer are held between a first electrode and a second electrode. The photoelectric conversion layer is a bulk heterojunction layer, and fullerene or a fullerene derivative is used as an n-type organic semiconductor. As a p-type organic semiconductor, a polymer represented by the following Expression is used. In the Expression, R1, R2, R3, and R4 each independently represent any one of a branched alkyl group, a linear alkyl group, an alkyl ester group, a carboxy alkyl group, and an alkoxy group. Independently, X is any one of S, O, and N.
    Type: Application
    Filed: September 3, 2013
    Publication date: January 2, 2014
    Applicants: National University Corporation of Hiroshima University, JX Nippon Oil & Energy Corporation
    Inventors: Seunghun EU, Tsuyoshi Asano, Itaru Osaka, Kazuo Takimiya
  • Patent number: 8372596
    Abstract: The present invention provides a prompt and easy asbestos detection method and a method for screening a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor. It is possible to quickly and easily detect asbestos in a sample by finding a protein capable of binding specifically to asbestos, allowing the protein or a fusion protein of the protein and a reporter protein to bind to asbestos in the sample, and then detecting the protein or the fusion protein having been bound to asbestos. A substance inhibiting the binding of actin to asbestos, which has been found out as a protein capable of binding specifically to asbestos, is a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: February 12, 2013
    Assignee: National University of Corporation Hiroshima University
    Inventors: Akio Kuroda, Kazutaka Nomura
  • Publication number: 20120305899
    Abstract: An object of the present invention is to provide a polymer compound providing high charge mobility. The polymer compound of the present invention has a repeating unit represented by the formula (1): wherein Ar1 and Ar2 are each an aromatic hydrocarbon ring, a heterocycle, or a fused ring of an aromatic hydrocarbon ring and a heterocycle; and R1, R2, R3 and R4 each represent a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an aryl group, an aryloxy group, an arylthio group, an arylalkyl group, an arylalkoxy group, an arylalkylthio group, a substituted silyl group, an unsubstituted or substituted carboxyl group, a monovalent heterocyclic group, a cyano group or a fluorine atom.
    Type: Application
    Filed: December 22, 2010
    Publication date: December 6, 2012
    Applicants: NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITY, SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Kazuo Taki, Itaru Osaka, Kenji Kohiro, Kenichiro Ohya, Kunihito Miyake
  • Patent number: 8084624
    Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-erffect mobility and high on/off current ratio required for organic semiconductor materials.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: December 27, 2011
    Assignee: National University of Corporation Hiroshima University
    Inventors: Kazuo Takimiya, Yoshihito Kunugi, Yasushi Konda
  • Patent number: 7960312
    Abstract: Disclosed is a method for immobilizing a target protein to the surface of silicon oxide-containing substance such as glass without modifying the surface of silicon oxide-containing substance by using a protein binding strongly to silicon oxide-containing substance. A protein capable binding strongly to silicon oxide-containing substance such as glass has been found, and thus a target protein can be directly bound and immobilized to the surface of silicon oxide-containing substance via the found protein. In addition, a fusion protein of the found protein and a target protein can be bound and immobilized to silicon oxide-containing substance.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: June 14, 2011
    Assignee: National University of Corporation Hiroshima University
    Inventors: Akio Kuroda, Kazutaka Nomura
  • Patent number: 7871548
    Abstract: A method and means for determining a critical elongation strain rate of a polymer melt, which make it possible to subject a polymer melt to elongation to prepare a bulk oriented melt, are established, and a process for producing bulk polymer oriented crystals and polymer oriented crystals are provided. In the critical elongation strain rate determination process or critical elongation strain rate determining method, a polymer melt (3) in a disc shape having a radius x0 and a thickness of ?z0 is held between transparent plates (an upper transparent plate (1) and a lower transparent plate (2)). The polymer melt (3) is cooled to a supercooled state and is press in a thickness direction at a constant rate v by using the transparent plates. The critical point radius x*, at which the polymer melt (3) is turned to an oriented crystal, is measured, and the critical elongation strain rate ? is calculated by equation ?*=ax*3 wherein ?=v/(2?z0x03).
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: January 18, 2011
    Assignee: National University of Corporation Hiroshima University
    Inventors: Masamichi Hikosaka, Kaori Watanabe
  • Patent number: 7867732
    Abstract: In one embodiment of the present application, a polypeptide capable of binding to a sugar chain is disclosed, particularly a high-mannose-type sugar chain bound to an antibody, more preferably a sugar chain bound to a chicken antibody. Also disclosed is a method for the purification of an antibody (specifically a chicken antibody) as a representative application of the polypeptide. Further disclosed is means for the purification. The polypeptide, BML-17, is a novel lectin made of 168 amino acid residues isolated from Bryopsis maxima. By using BML-17, it becomes possible to purify an antibody (e.g., a chicken antibody) readily and with high efficiency.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: January 11, 2011
    Assignee: National University of Corporation Hiroshima University
    Inventors: Kanji Hori, Haruo Matsuda
  • Patent number: 7834198
    Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-effect mobility and high on/off current ratio required for organic semiconductor materials.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: November 16, 2010
    Assignee: National University of Corporation Hiroshima University
    Inventors: Kazuo Takimiya, Yoshihito Kunugi, Yasushi Konda
  • Patent number: 7537748
    Abstract: A hydrogen storage matter contains at least a nano-structured and organized lithium imide compound precursor complex. In the hydrogen stroge matter, the lithium imide compound precursor complex has been nano-structured and organized by mixing fine powder lithium amide with fine powder lithium hydride at a predetermined ratio to prepare a mixture as a starting material, and then processing the mixture by a predetermined complex formation processing method.
    Type: Grant
    Filed: February 9, 2006
    Date of Patent: May 26, 2009
    Assignees: National University Corporation, Hiroshima University, Taiheiyo Cement Corporation
    Inventors: Hironobu Fujii, Takayuki Ichikawa, Haiyan Leng, Shigehito Isobe, Nobuko Hanada, Toyoyuki Kubokawa, Kazuhiko Tokoyoda, Keisuke Okamoto, Shinkichi Tanabe, Shigeru Matsuura, Kenji Ogawa
  • Publication number: 20090118142
    Abstract: Disclosed is a method for immobilizing a target protein to the surface of silicon oxide-containing substance such as glass without modifying the surface of silicon oxide-containing substance by using a protein binding strongly to silicon oxide-containing substance. A protein capable binding strongly to silicon oxide-containing substance such as glass has been found, and thus a target protein can be directly bound and immobilized to the surface of silicon oxide-containing substance via the found protein. In addition, a fusion protein of the found protein and a target protein can be bound and immobilized to silicon oxide-containing substance.
    Type: Application
    Filed: November 9, 2006
    Publication date: May 7, 2009
    Applicant: National University of Corporation Hiroshima University
    Inventors: Akio Kuroda, Kazutaka Momura