Patents Assigned to National University of Corporation Hiroshima University
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Patent number: 10626141Abstract: The present invention provides a method for specifically cleaving a C?-C bond of a peptide backbone and/or a side chain of a protein and a peptide, and a method for determining amino acid sequences of protein and peptide. A method for specifically cleaving a C?-C bond of a peptide backbone and/or a side chain bond of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of at least one hydroxynitrobenzoic acid selected from the group consisting of 3-hydroxy-2-nitrobenzoic acid, 4-hydroxy-3-nitrobenzoic acid, 5-hydroxy-2-nitrobenzoic acid, 3-hydroxy-5-nitrobenzoic acid, and 4-hydroxy-2-nitrobenzoic acid. A method for determining an amino acid sequence of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of the above specific hydroxynitrobenzoic acid to specifically cleave a C?-C bond of a peptide backbone and/or a side chain bond, and analyzing generated fragment ions by mass spectrometry.Type: GrantFiled: May 12, 2017Date of Patent: April 21, 2020Assignees: SHIMADZU CORPORATION, NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITYInventors: Shunsuke Izumi, Koichi Tanaka, Yuko Fukuyama
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Patent number: 10461669Abstract: A wind power generation system including a power generation unit having an elastically deformable base material in a shape of a longitudinal flat plate and a piezoelectric element disposed on the base material, and which generates electricity as the power generation unit is vibrated; the piezoelectric element is repeatedly bent and deformed by the vibration and stacked on the base material, the wind power generation system being configured to include a tension adjusting device that, when a wind speed is increased, moves the movable member to increase a tensile force that pulls the power generation unit in the longitudinal direction, and the tension adjusting device being a lift generating member that is formed integrally with the movable member so as to be extended and to have wing shape to both sides of the movable member and that moves the movable member based on lift generated according to the wind speed.Type: GrantFiled: April 16, 2015Date of Patent: October 29, 2019Assignees: TOYODA IRON WORKS CO., LTD., NATIONAL UNIVERSITY CORPORATION HIROSHIMA UNIVERSITYInventors: Hidenobu Takao, Yasuhiro Sone, Hidemi Mutsuda, Yoshikazu Tanaka
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Publication number: 20190115434Abstract: Semiconductor devices each include: a semiconductor substrate that contains beta-gallium oxide and has a first conductivity type; a first semiconductor region that contains beta-gallium oxide, has the first conductivity type, and is provided on an upper side of the semiconductor substrate; a second semiconductor region that contains beta-gallium oxide, has a second conductivity type, and is provided on an upper side of a part of the first semiconductor region; and a third semiconductor region that contains beta-gallium oxide, has the first conductivity type, and is provided on an upper side of a part of the second semiconductor region. When the first conductivity type is an n-type and the second conductivity type is a p-type, the second semiconductor region further contains a band gap control element. The band gap control element is selected from a group of boron, aluminum, and indium.Type: ApplicationFiled: October 15, 2018Publication date: April 18, 2019Applicants: Yazaki Corporation, National University Corporation Hiroshima UniversityInventors: Naotake SAKUMOTO, Yoshinori MATSUSHITA, Hiroki ISHIHARA, Tatsuo SUNAYAMA, Misako AIDA, Yoriko TOMINAGA, Dai AKASE
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Patent number: 10075103Abstract: A power generation device for a mobile body includes power generating units and a holding member. Each power generating unit includes an elastically deformable base member and a piezoelectric film, which are laminated alternately. The holding member holds the power generating units. Each power generating unit has an elongated flat-plate shape. Opposite ends of the power generating unit in a longitudinal direction are held by the holding member such that the power generating unit is in an orientation in which a longitudinal axis is substantially perpendicular to the flow direction of the external fluid. A fixing member is provided at each of the opposite ends in the longitudinal direction of each power generating unit. The power generating units are arranged in the holding member via the fixing members to pivot in accordance with the flow of the external fluid.Type: GrantFiled: July 14, 2014Date of Patent: September 11, 2018Assignees: TOYODA IRON WORKS CO., LTD., NATIONAL UNIVERSITY CORPORATION HIROSHIMA UNIVERSITYInventors: Hidenobu Takao, Yasuhiro Sone, Hidemi Mutsuda, Yoshikazu Tanaka
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Patent number: 9453846Abstract: The present invention provides a mass spectrometry method using a matrix that is capable of easily and efficiently improving ionization efficiency in mass spectrometry without modifying a molecule to be analyzed, and a matrix for mass spectrometry. A mass spectrometry method using, as a matrix, a 2,4,6-trihydroxyalkylphenone represented by the following general formula (I): where R is an alkyl group having 4 to 12 carbon atoms. The mass spectrometry method as described above, wherein an analysis object is a hydrophobic compound, particularly, a hydrophobic peptide.Type: GrantFiled: March 4, 2014Date of Patent: September 27, 2016Assignees: SHIMADZU CORPORATION, NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITYInventors: Yuko Fukuyama, Shunsuke Izumi
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Patent number: 9312491Abstract: A photoelectric conversion element has a structure where a hole transport layer, a photoelectric conversion layer, and an electron transport layer are held between a first electrode and a second electrode. The photoelectric conversion layer is a bulk heterojunction layer, and fullerene or a fullerene derivative is used as an n-type organic semiconductor. As a p-type organic semiconductor, a polymer represented by the following Expression is used. In the Expression, R1, R2, R3, and R4 each independently represent any one of a branched alkyl group, a linear alkyl group, an alkyl ester group, a carboxy alkyl group, and an alkoxy group. Independently, X is any one of S, O, and N.Type: GrantFiled: September 3, 2013Date of Patent: April 12, 2016Assignees: JX NIPPON OIL & ENERGY CORPORATION, NATIONAL UNIVERSITY CORPORATION OF HIROSHIMA UNIVERSITYInventors: Seunghun Eu, Tsuyoshi Asano, Itaru Osaka, Kazuo Takimiya
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Patent number: 9209409Abstract: A naphthobisthiadiazole derivative is represented by Formula 1. In Formula 1, Z is selected from a hydrogen atom, a boronic acid group, a boronic acid ester group, a trifluoroborate salt group and a triolborate salt group, and at least one Z is a boronic acid group, a boronic acid ester group, a trifluoroborate salt group or a triolborate salt group. The naphthobisthiadiazole derivative is an organoboron compound, and can be converted to various compounds by a Suzuki-Miyaura coupling reaction; thus, is applicable as a precursor of complex compounds. Using the naphthobisthiadiazole derivative, research, development, and practical applications of low molecular weight compounds and high-molecular compounds useful for various organic semiconductor materials and the like can be ensured.Type: GrantFiled: February 27, 2013Date of Patent: December 8, 2015Assignees: National University of Corporation Hiroshima University, Sankyo Kasei Co., Ltd.Inventors: Kazuo Takimiya, Itaru Osaka, Kazuaki Kawashima
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Patent number: 9018398Abstract: An intermediate for an acenedichalcogenophene derivative is expressed by formula (1) or formula (2). In the formulae (1) and (2), Ar1 represents any one ring of a benzene ring, a naphthalene ring, or an anthracene ring having at least one of hydrogen thereof is substituted with a boronic acid group or a boronate ester group; Y represents an oxygen atom, a sulfur atom, or a selenium atom; and Z represents a substituent group. This intermediate for the acenedichalcogenophene derivative is capable of easily deprotecting the boronic acid group or the boronate ester group and allowing a substitution with a desired functional group, such that a desired synthesis of acenedichalcogenophene derivative, and further a desired synthesis of oligomers and polymers using this obtained acenedichalcogenophene derivative can be achieved.Type: GrantFiled: December 12, 2012Date of Patent: April 28, 2015Assignee: National University of Corporation Hiroshima UniversityInventors: Kazuo Takimiya, Itaru Osaka
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Patent number: 8921836Abstract: An object of the present invention is to provide a polymer compound providing high charge mobility. The polymer compound of the present invention has a repeating unit represented by the formula (1): wherein Ar1 and Ar2 are each an aromatic hydrocarbon ring, a heterocycle, or a fused ring of an aromatic hydrocarbon ring and a heterocycle; and R1, R2, R3 and R4 each represent a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an aryl group, an aryloxy group, an arylthio group, an arylalkyl group, an arylalkoxy group, an arylalkylthio group, a substituted silyl group, an unsubstituted or substituted carboxyl group, a monovalent heterocyclic group, a cyano group or a fluorine atom.Type: GrantFiled: December 22, 2010Date of Patent: December 30, 2014Assignees: Sumitomo Chemical Company, Limited, National University of Corporation Hiroshima UniversityInventors: Kazuo Takimiya, Itaru Osaka, Kenji Kohiro, Kenichiro Ohya, Kunihito Miyake
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Patent number: 8771983Abstract: A method is disclosed for releasing the transcriptional regulation caused by a repeated sequence in a gene, a kit therefor and so on to thereby establish a system capable of producing a protein in a large amount.Type: GrantFiled: August 14, 2007Date of Patent: July 8, 2014Assignee: National University of Corporation Hiroshima UniversityInventor: Noriaki Shimizu
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Publication number: 20140000716Abstract: A photoelectric conversion element has a structure where a hole transport layer, a photoelectric conversion layer, and an electron transport layer are held between a first electrode and a second electrode. The photoelectric conversion layer is a bulk heterojunction layer, and fullerene or a fullerene derivative is used as an n-type organic semiconductor. As a p-type organic semiconductor, a polymer represented by the following Expression is used. In the Expression, R1, R2, R3, and R4 each independently represent any one of a branched alkyl group, a linear alkyl group, an alkyl ester group, a carboxy alkyl group, and an alkoxy group. Independently, X is any one of S, O, and N.Type: ApplicationFiled: September 3, 2013Publication date: January 2, 2014Applicants: National University Corporation of Hiroshima University, JX Nippon Oil & Energy CorporationInventors: Seunghun EU, Tsuyoshi Asano, Itaru Osaka, Kazuo Takimiya
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Patent number: 8372596Abstract: The present invention provides a prompt and easy asbestos detection method and a method for screening a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor. It is possible to quickly and easily detect asbestos in a sample by finding a protein capable of binding specifically to asbestos, allowing the protein or a fusion protein of the protein and a reporter protein to bind to asbestos in the sample, and then detecting the protein or the fusion protein having been bound to asbestos. A substance inhibiting the binding of actin to asbestos, which has been found out as a protein capable of binding specifically to asbestos, is a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor.Type: GrantFiled: November 8, 2006Date of Patent: February 12, 2013Assignee: National University of Corporation Hiroshima UniversityInventors: Akio Kuroda, Kazutaka Nomura
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Publication number: 20120305899Abstract: An object of the present invention is to provide a polymer compound providing high charge mobility. The polymer compound of the present invention has a repeating unit represented by the formula (1): wherein Ar1 and Ar2 are each an aromatic hydrocarbon ring, a heterocycle, or a fused ring of an aromatic hydrocarbon ring and a heterocycle; and R1, R2, R3 and R4 each represent a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an aryl group, an aryloxy group, an arylthio group, an arylalkyl group, an arylalkoxy group, an arylalkylthio group, a substituted silyl group, an unsubstituted or substituted carboxyl group, a monovalent heterocyclic group, a cyano group or a fluorine atom.Type: ApplicationFiled: December 22, 2010Publication date: December 6, 2012Applicants: NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITY, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Kazuo Taki, Itaru Osaka, Kenji Kohiro, Kenichiro Ohya, Kunihito Miyake
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Patent number: 8084624Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-erffect mobility and high on/off current ratio required for organic semiconductor materials.Type: GrantFiled: October 5, 2010Date of Patent: December 27, 2011Assignee: National University of Corporation Hiroshima UniversityInventors: Kazuo Takimiya, Yoshihito Kunugi, Yasushi Konda
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Patent number: 7960312Abstract: Disclosed is a method for immobilizing a target protein to the surface of silicon oxide-containing substance such as glass without modifying the surface of silicon oxide-containing substance by using a protein binding strongly to silicon oxide-containing substance. A protein capable binding strongly to silicon oxide-containing substance such as glass has been found, and thus a target protein can be directly bound and immobilized to the surface of silicon oxide-containing substance via the found protein. In addition, a fusion protein of the found protein and a target protein can be bound and immobilized to silicon oxide-containing substance.Type: GrantFiled: November 9, 2006Date of Patent: June 14, 2011Assignee: National University of Corporation Hiroshima UniversityInventors: Akio Kuroda, Kazutaka Nomura
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Patent number: 7871548Abstract: A method and means for determining a critical elongation strain rate of a polymer melt, which make it possible to subject a polymer melt to elongation to prepare a bulk oriented melt, are established, and a process for producing bulk polymer oriented crystals and polymer oriented crystals are provided. In the critical elongation strain rate determination process or critical elongation strain rate determining method, a polymer melt (3) in a disc shape having a radius x0 and a thickness of ?z0 is held between transparent plates (an upper transparent plate (1) and a lower transparent plate (2)). The polymer melt (3) is cooled to a supercooled state and is press in a thickness direction at a constant rate v by using the transparent plates. The critical point radius x*, at which the polymer melt (3) is turned to an oriented crystal, is measured, and the critical elongation strain rate ? is calculated by equation ?*=ax*3 wherein ?=v/(2?z0x03).Type: GrantFiled: August 31, 2006Date of Patent: January 18, 2011Assignee: National University of Corporation Hiroshima UniversityInventors: Masamichi Hikosaka, Kaori Watanabe
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Patent number: 7867732Abstract: In one embodiment of the present application, a polypeptide capable of binding to a sugar chain is disclosed, particularly a high-mannose-type sugar chain bound to an antibody, more preferably a sugar chain bound to a chicken antibody. Also disclosed is a method for the purification of an antibody (specifically a chicken antibody) as a representative application of the polypeptide. Further disclosed is means for the purification. The polypeptide, BML-17, is a novel lectin made of 168 amino acid residues isolated from Bryopsis maxima. By using BML-17, it becomes possible to purify an antibody (e.g., a chicken antibody) readily and with high efficiency.Type: GrantFiled: February 27, 2006Date of Patent: January 11, 2011Assignee: National University of Corporation Hiroshima UniversityInventors: Kanji Hori, Haruo Matsuda
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Patent number: 7834198Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-effect mobility and high on/off current ratio required for organic semiconductor materials.Type: GrantFiled: January 18, 2006Date of Patent: November 16, 2010Assignee: National University of Corporation Hiroshima UniversityInventors: Kazuo Takimiya, Yoshihito Kunugi, Yasushi Konda
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Patent number: 7537748Abstract: A hydrogen storage matter contains at least a nano-structured and organized lithium imide compound precursor complex. In the hydrogen stroge matter, the lithium imide compound precursor complex has been nano-structured and organized by mixing fine powder lithium amide with fine powder lithium hydride at a predetermined ratio to prepare a mixture as a starting material, and then processing the mixture by a predetermined complex formation processing method.Type: GrantFiled: February 9, 2006Date of Patent: May 26, 2009Assignees: National University Corporation, Hiroshima University, Taiheiyo Cement CorporationInventors: Hironobu Fujii, Takayuki Ichikawa, Haiyan Leng, Shigehito Isobe, Nobuko Hanada, Toyoyuki Kubokawa, Kazuhiko Tokoyoda, Keisuke Okamoto, Shinkichi Tanabe, Shigeru Matsuura, Kenji Ogawa
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Publication number: 20090118142Abstract: Disclosed is a method for immobilizing a target protein to the surface of silicon oxide-containing substance such as glass without modifying the surface of silicon oxide-containing substance by using a protein binding strongly to silicon oxide-containing substance. A protein capable binding strongly to silicon oxide-containing substance such as glass has been found, and thus a target protein can be directly bound and immobilized to the surface of silicon oxide-containing substance via the found protein. In addition, a fusion protein of the found protein and a target protein can be bound and immobilized to silicon oxide-containing substance.Type: ApplicationFiled: November 9, 2006Publication date: May 7, 2009Applicant: National University of Corporation Hiroshima UniversityInventors: Akio Kuroda, Kazutaka Momura