Patents Assigned to Neurocentria, Inc.
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Patent number: 11717501Abstract: Provided is a dosage form comprising magnesium threonate having enhanced efficacy. Also provided is a pharmacokinetic profile of magnesium threonate having enhanced efficacy. The dosage forms and pharmacokinetic profile of magnesium threonate are used to treat a variety of diseases, disorders, syndromes and/or conditions.Type: GrantFiled: April 24, 2019Date of Patent: August 8, 2023Assignee: Neurocentria, Inc.Inventors: Guosong Liu, Fei Mao, Jason Gregory Weinger
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Patent number: 11298330Abstract: The present invention provides a method of administering magnesium threonate to a subject in need of supplementing magnesium. At least a portion of magnesium (Mg) and threonate (T) is present in a salt form of MgT2. The method may comprise administration of magnesium threonate at two different time points per day. The method may comprise administering, at a first time point, a first oral dosage form comprising magnesium threonate. The method may comprise administering, at a second time point, a combination of the first oral dosage form and a second oral dosage form comprising magnesium threonate. The first and second oral dosage forms may exhibit different dissolution profiles in a dissolution medium.Type: GrantFiled: October 25, 2019Date of Patent: April 12, 2022Assignee: Neurocentria, Inc.Inventors: Guosong Liu, Fei Mao, Jason Weinger
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Patent number: 11278567Abstract: Methods for modifying neuronal functional activity and/or treating a neurological disorder by using agents that raise neuronal intracellular concentration of magnesium are disclosed. Also provided herein are methods of determining the amenability of an individual to treatment for a neurological disorder, by measuring changes in intracellular magnesium concentration.Type: GrantFiled: February 27, 2020Date of Patent: March 22, 2022Assignee: Neurocentria, Inc.Inventors: Guosong Liu, Hang Zhou
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Patent number: 10617713Abstract: Methods for modifying neuronal functional activity and/or treating a neurological disorder by using agents that raise neuronal intracellular concentration of magnesium are disclosed. Also provided herein are methods of determining the amenability of an individual to treatment for a neurological disorder, by measuring changes in intracellular magnesium concentration.Type: GrantFiled: July 14, 2016Date of Patent: April 14, 2020Assignee: Neurocentria, Inc.Inventors: Guosong Liu, Hang Zhou
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Patent number: 10493048Abstract: Provided herein is a method of using threonate to alter cellular physiology, such as neuronal physiology. A method of the present disclosure may include providing to a medium comprising a cell, a threonate-containing compound, or a precursor thereof, to increase the concentration of threonate in the medium, where the increased concentration of threonate is sufficient to increase the concentration of magnesium in the cell. Also provided is a method that includes administering a threonate-containing compound, or a precursor thereof, to an individual, to increase synaptic density in the brain and/or to treat a neurological disorder, e.g., cognitive impairment. The threonate-containing compound of the present disclosure does not include magnesium threonate.Type: GrantFiled: September 7, 2016Date of Patent: December 3, 2019Assignee: Neurocentria, Inc.Inventors: Guosong Liu, Fei Mao, Qifeng Sun
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Patent number: 9937137Abstract: Compositions and methods that are useful for treating a subject suffering from one or more cancers are provided herein. Such compositions and methods can contain an effective amount of magnesium threonate to be used to support or improve the mental state of a subject. The composition and methods comprising magnesium threonate can also be used to support a cancer treatment.Type: GrantFiled: March 14, 2014Date of Patent: April 10, 2018Assignee: Neurocentria, Inc.Inventors: Guosong Liu, Fei Mao
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Patent number: 9757414Abstract: A composition for administration to a subject, such as oral administration to a subject, for example, has been provided. Such a composition may comprise at least one magnesium-counter ion compound. A magnesium-counter ion composition described herein may be useful for any of a variety of applications provided herein, such as maintaining, enhancing, and/or improving health, nutrition, and/or another condition of a subject, and/or cognitive, learning, and/or memory function. A magnesium-counter ion composition provided herein may be useful for administration to a subject presenting magnesium deficiency, mild cognitive impairment, Alzheimer's disease, attention deficit hyperactivity disorder, ALS, Parkinson's disease, diabetes, migraine, anxiety disorder, mood disorder, and/or hypertension. A kit, method, and other associated technology are also provided.Type: GrantFiled: November 4, 2016Date of Patent: September 12, 2017Assignee: Neurocentria, Inc.Inventors: Guosong Liu, Fei Mao
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Patent number: 9737563Abstract: A composition for administration to a subject, such as oral administration to a subject, for example, has been provided. Such a composition may comprise at least one magnesium-counter ion compound. A magnesium-counter ion composition described herein may be useful for any of a variety of applications provided herein, such as maintaining, enhancing, and/or improving health, nutrition, and/or another condition of a subject, and/or cognitive, learning, and/or memory function. A magnesium-counter ion composition provided herein may be useful for administration to a subject presenting magnesium deficiency, mild cognitive impairment, Alzheimer's disease, attention deficit hyperactivity disorder, ALS, Parkinson's disease, diabetes, migraine, anxiety disorder, mood disorder, and/or hypertension. A kit, method, and other associated technology are also provided.Type: GrantFiled: November 4, 2016Date of Patent: August 22, 2017Assignee: Neurocentria, Inc.Inventors: Guosong Liu, Fei Mao
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Patent number: 9616038Abstract: A composition for administration to a subject, such as oral administration to a subject, for example, has been provided. Such a composition may comprise at least one magnesium-counter ion compound. A magnesium-counter ion composition described herein may be useful for any of a variety of applications provided herein, such as maintaining, enhancing, and/or improving health, nutrition, and/or another condition of a subject, and/or cognitive, learning, and/or memory function. A magnesium-counter ion composition provided herein may be useful for administration to a subject presenting magnesium deficiency, mild cognitive impairment, Alzheimer's disease, attention deficit hyperactivity disorder, ALS, Parkinson's disease, diabetes, migraine, anxiety disorder, mood disorder, and/or hypertension. A kit, method, and other associated technology are also provided.Type: GrantFiled: July 22, 2015Date of Patent: April 11, 2017Assignee: Neurocentria, Inc.Inventors: Guosong Liu, Fei Mao