Patents Assigned to Neurogenetic Pharmaceuticals, Inc.
  • FORMULATIONS CONTAINING GAMMA SECRETASE MODULATORS, METHODS FOR PREPARATION AND DELIVERY THEREOF
    Publication number: 20150045353
    Abstract: In accordance with the present invention, there are provided formulations of gamma secretase modulators (GSMs) which are suitable for oral delivery and have improved transport properties relative to prior art formulations thereof. Also provided are methods for the preparation of such improved formulations and uses thereof for the delivery of GSMs to subjects in need thereof.
    Type: Application
    Filed: August 9, 2013
    Publication date: February 12, 2015
    Applicant: Neurogenetic Pharmaceuticals, Inc.
    Inventors: William T. COMER, Maria Z. KOUNNAS, Bryan M. KNOX, Nathan S. BARKSDALE
  • Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor
    Patent number: 8871460
    Abstract: In accordance with the present invention, it has been discovered that compounds which modulate the ?-secretase enzyme to make more of the shorter, less toxic and less aggregation-prone A? peptides (such as A?37 and A?38), while making less of the longer and more toxic and aggregation-prone AB peptides (such as AB40 and AB42) are useful as gamma-secretase modulators. In addition, these GSM compounds have further been discovered to have the selective property of modulating the formation of various AB peptides, while not inhibiting the overall activity of the ?-secretase enzyme. Thus, such compounds do not impede other critical functions of the ?-secretase enzyme, such as generating fragments from Notch that appear to control gene expression and cell differentiation. Therefore, in accordance with the present invention, there are provided screening assays useful for determining whether test compounds have GSM activity; accordingly, invention assays facilitate the identification of new gamma-secretase modulators.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: October 28, 2014
    Assignee: Neurogenetic Pharmaceuticals, Inc.
    Inventors: Maria Z. Kounnas, Elizabeth J. Ackermann, Kenneth A. Stauderman, Gonul Velicelebi, Steve Wagner
  • ?-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom
    Patent number: 8119680
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: February 21, 2012
    Assignee: Neurogenetic Pharmaceuticals, Inc.
    Inventors: Soan Cheng, Daniel D Comer, Long Mao, Guity P Balow, David Pleynet
  • Compounds and uses thereof in modulating amyloid ?
    Patent number: 8017629
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: September 13, 2011
    Assignee: Neurogenetic Pharmaceuticals, Inc.
    Inventors: Soan Cheng, Daniel D. Comer, Long Mao, Guity P. Balow, David Pleynet
  • ?-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom
    Patent number: 7799808
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: September 21, 2010
    Assignee: Neurogenetic Pharmaceuticals, Inc.
    Inventors: Soan Cheng, Daniel D. Comer, Long Mao, Guity P. Balow, David Pleynet
  • Compounds and uses thereof in modulating amyloid beta
    Patent number: 7781442
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: August 24, 2010
    Assignee: Neurogenetic Pharmaceuticals, Inc.
    Inventors: Soan Cheng, Daniel D. Comer, Long Mao, Guity P. Balow, David Pleynet