Patents Assigned to Neurologix, Inc.
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Publication number: 20120071546Abstract: The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that deliver therapeutic agents to specific regions of the brain.Type: ApplicationFiled: November 29, 2011Publication date: March 22, 2012Applicant: NEUROLOGIX, INC.Inventors: Helen Fitzsimons, Ross Bland
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Publication number: 20120039991Abstract: The invention provides methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain associated with a neurodegenerative diseases that is characterized by an excess buildup of buildup of intracellular protein aggregates. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding an inhibitor of apoptosis protein (IAP) to cells in the region.Type: ApplicationFiled: August 17, 2011Publication date: February 16, 2012Applicant: NEUROLOGIX, INC.Inventors: Michael Kaplitt, Serguei Moussatov
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Patent number: 8071563Abstract: The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that deliver therapeutic agents to specific regions of the brain. More specifically, using an adeno-associated viral vector to deliver a nucleotide sequence encoding a novel glutamic acid decarboxylase (GAD) to specific regions of the brain that are over stimulated or disinhibited in various diseases, including neurodegenerative diseases.Type: GrantFiled: March 24, 2009Date of Patent: December 6, 2011Assignee: Neurologix, Inc.Inventors: Helen Fitzsimons, Ross Bland
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Patent number: 8017385Abstract: The invention provides methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain associated with a neurodegenerative diseases that is characterized by an excess buildup of buildup of intracellular protein aggregates. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding an inhibitor of apoptosis protein (IAP) to cells in the region.Type: GrantFiled: October 21, 2005Date of Patent: September 13, 2011Assignee: Neurologix, Inc.Inventors: Michael Kaplitt, Serguei Moussatov
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Publication number: 20110207802Abstract: The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus.Type: ApplicationFiled: April 27, 2011Publication date: August 25, 2011Applicant: NEUROLOGIX, INC.Inventors: Matthew During, Michael Kaplitt
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Patent number: 7955595Abstract: The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus.Type: GrantFiled: January 11, 2010Date of Patent: June 7, 2011Assignee: Neurologix, Inc.Inventors: Matthew During, Michael Kaplitt
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Publication number: 20100168215Abstract: The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional fragment thereof in the target cell(s) provides therapeutic benefit for subjects afflicted with a neurological disorder.Type: ApplicationFiled: March 1, 2010Publication date: July 1, 2010Applicant: NEUROLOGIX, INC.Inventors: Matthew J. During, Annamaria Vezzani
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Publication number: 20100143458Abstract: The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus.Type: ApplicationFiled: January 11, 2010Publication date: June 10, 2010Applicant: NEUROLOGIX, INC.Inventors: Matthew During, Michael Kaplitt
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Patent number: 7723288Abstract: The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional fragment thereof in the target cell(s) provides therapeutic benefit for subjects afflicted with a neurological disorder.Type: GrantFiled: October 14, 2004Date of Patent: May 25, 2010Assignee: Neurologix, Inc.Inventors: Matthew J. During, Annamaria Vezzani
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Publication number: 20100093058Abstract: The present invention related to methods and compositions comprising recombinant vectors comprising chimeric capsids and recombinant pseudotyped vectors with non-native capsid protein(s). The recombinant vectors of the invention confer an altered tropism that permits selective targeting of desired cells.Type: ApplicationFiled: November 18, 2009Publication date: April 15, 2010Applicant: NEUROLOGIX, INC.Inventors: Yuhong Liu, Jia Luo, Matthew During
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Patent number: 7695959Abstract: The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus.Type: GrantFiled: March 16, 2004Date of Patent: April 13, 2010Assignee: Neurologix, Inc.Inventors: Matthew During, Michael Kaplitt
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Patent number: 7645446Abstract: The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the subthalmic nucleus of the basal ganglia, mesaphilia and thalamus.Type: GrantFiled: March 16, 2004Date of Patent: January 12, 2010Assignee: Neurologix, Inc.Inventors: Matthew During, Michael Kaplitt
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Publication number: 20090233994Abstract: The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that deliver therapeutic agents to specific regions of the brain.Type: ApplicationFiled: March 24, 2009Publication date: September 17, 2009Applicant: NEUROLOGIX, INC.Inventors: Helen Fitzsimons, Ross Bland
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Publication number: 20090214637Abstract: The present application relates to novel methods and compositions for treating metabolic disorders. Some aspects pertain to the use of gene therapy to treat diseases related to metabolic disorders, such as diabetes, obesity, high blood pressure, wasting syndrome, cachexia and atherogenic dyslipidemia. The present application also pertains to the use of vectors such as a recombinant adeno-associated virus (AAV) to deliver a at least a portion of a gene that can increase or decrease expression of a therapeutic protein of interest, e.g., in cells in a specific region of the brain associated with metabolic disorder. The present application also discloses the use of vectors such as a recombinant adeno-associated virus for the delivery of small interference RNA's (siRNAs) capable of decreasing expression of a deleterious protein involved in the disorder. Other related aspects, including compositions related to such methods, are also disclosed.Type: ApplicationFiled: April 30, 2009Publication date: August 27, 2009Applicant: NEUROLOGIX, INC.Inventor: Sergey Musatov
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Patent number: 7527785Abstract: The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that deliver therapeutic agents to specific regions of the brain. More specifically, using an adeno-associated viral vector to deliver a nucleotide sequence encoding a novel glutamic acid decarboxylase (GAD) to specific regions of the brain that are over stimulated or disinhibited in various diseases, including neurodegenerative diseases.Type: GrantFiled: May 31, 2006Date of Patent: May 5, 2009Assignee: Neurologix, Inc.Inventors: Helen Fitzsimons, Ross Bland
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Publication number: 20090110661Abstract: The present application relates to novel methods for treating obesity. Some aspects pertain to the use of gene therapy to treat diseases related to metabolic dysfunction, such as diabetes, obesity, high blood pressure, and atherogenic dyslipidemia. The present application also pertains to the use of vectors such as a recombinant adeno-associated virus (AAV) to deliver a gene that can increase or decrease expression of a therapeutic protein of interest, e.g., in cells in a specific region of the brain associated with metabolic dysfunction. The present application also discloses the use of vectors such as a recombinant adeno-associated virus for the delivery of small interference RNA's (siRNAs) capable of decreasing expression of a deleterious protein involved in the disorder. Other related aspects, including compositions related to such methods, are also disclosed.Type: ApplicationFiled: October 30, 2008Publication date: April 30, 2009Applicant: NEUROLOGIX, INC.Inventor: Sergey Musatov
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Publication number: 20090098631Abstract: The invention relates to novel Glutamic Acid Decarboxylases (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that deliver therapeutic agents to specific regions of the brain. More specifically, using an adeno-associated viral vector to deliver a nucleotide sequence encoding a novel glutamic acid decarboxylase (GAD) to specific regions of the brain that are over stimulated or disinhibited in various diseases, including neurodegenerative diseases.Type: ApplicationFiled: August 1, 2007Publication date: April 16, 2009Applicant: NEUROLOGIX, INC.Inventors: Helen Lisa Fitzsimons, Ross James Bland
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Publication number: 20060228776Abstract: The invention provides methods and compositions of an upstream regulatory element (PINK-1 promoter) operably linked to an expressible gene, wherein the expression of the expressible gene is driven by the upstream regulatory element.Type: ApplicationFiled: October 21, 2005Publication date: October 12, 2006Applicant: NEUROLOGIX, INC.Inventors: Michael Kaplitt, Serguei Moussatov
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Publication number: 20060210538Abstract: The invention provides methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain associated with a neurodegenerative diseases that is characterized by an excess buildup of buildup of intracellular protein aggregates. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding an inhibitor of apoptosis protein (IAP) to cells in the region.Type: ApplicationFiled: October 21, 2005Publication date: September 21, 2006Applicant: NEUROLOGIX, INC.Inventors: Michael Kaplitt, Serguei Moussatov
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Publication number: 20060099179Abstract: The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the subthalmic nucleus of the basal ganglia, mesaphilia and thalmus.Type: ApplicationFiled: March 16, 2004Publication date: May 11, 2006Applicant: NEUROLOGIX, INC.Inventors: Matthew During, Michael Kaplitt